Evaluation of Subtypes of Peripheral Blood Lymphocytes in Patients
with Vitiligo
Naser
Tayyebi Meibodi
Associate Professor of Pathology, Mashhad University of Medical Sciences, Mashhad, Iran
author
Zari
Javidi
Professor of Dermatology, Mashhad University of Medical Sciences, Mashhad, Iran
author
Mahmoud
Mahmodi
Professor of Immunology, Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
author
Masoud
Maleki
Associate Professor of Dermatology, Mashhad University of Medical Sciences, Mashhad, Iran
author
Yalda
Nahidi
Assistant Professor of Dermatology, Mashhad University of Medical Sciences, Mashhad, Iran
author
Monavar
Afzalaghaei
Specialist in Social Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
author
Bita
Safaee
Pathology departmentResident of Mashhad University of Medical Sciences, Mashhad, Iran
author
Mohammad
Ebrahimi Rad
Dermatologist, Mashhad, Iran
author
text
article
2009
per
Introduction Vitiligo is characterized with white patches on the skin and alteration of melanocytes in dermoepidermal junction. Autoimmune mechanisms with an underlying genetic predisposition are the most likely causes of vitiligo. This study was performed to evaluate immune disturbance in vitiligo and clarify its more details. Materials and Methods A total of 29 vitiligo patients and 21 healthy controls were included in this case control study. Complete blood count was measured and peripheral blood samples were evaluated flowcytometrically for surface antigenic markers including CD3, CD4, CD8, CD19, CD16, CD56 and CD25 for determining the percentage and total number of various lymphocyte subgroups. Patients with different clinical subtypes were compared with each other and controls in terms of the flowcytometry results. Obtained information was assessed by SPSS statistical software. Results Total numbers of CD3+, CD8+ T cells, B cells and CD25+ cells were significantly increased in generalized type vitiligo patients in comparison with localized type. CD25+ cells were also increased significantly in generalized and stable types of vitiligo compared with healthy controls and finally the total number of lymphocytes was significantly decreased in localized type vitiligo patients in comparison with healthy controls. Conclusion Our data indicate cellular immune disturbance in vitiligo. Disorders of immune regulatory system may play a major role in this context. Significant CD25+ or regulatory T cells increment in different clinical subtypes of the disease is in favor of the above hypothesis. Later and larger studies may result in new and effective routs of treatment for vitiligo acting through regulating immune system.
medical journal of mashhad university of medical sciences
دانشگاه علوم پزشکی مشهد
1735-4013
52
v.
4
no.
2009
198
202
https://mjms.mums.ac.ir/article_5410_0158ea6bb6bb047d35f82bbebcdd0ba6.pdf
dx.doi.org/10.22038/mjms.2009.5410
Right Ventricular Function before and after an uncomplicated Coronary Bypass Graft as Assessed by Pulsedwave Doppler Tissue Imaging of the Tricuspid Annulus
Afsoon
Fazlinejad
Cardiologist, Associate professor, MashhadUniversity of Medical Sciences, Mashhad, Iran
author
Afsaneh
Mohammadi
Cardiologist, MashhadUniversity of Medical Sciences, Mashhad, Iran
author
Behrouz
Mottahedi
CardiacSsurgeon, Aassistant professor,Mashhad University of Medical Sciences, Mashhad, Iran
author
Jamil
Esfahanizadeh
CardiacSsurgeon, Aassistant professor,Mashhad University of Medical Sciences, Mashhad, Iran
author
text
article
2009
per
Introduction RV function using myocardial velocities before and after a CABG is unknown. CABG on the beating heart without cardiac- pulmonary bypass (off- pump) has gainad increasing popularity. Improved post operative ventricular function has been cited as an advantage over on- pump surgery. Materials and Methods A total of 36 pts (26 male and 10 female) with significant coronary artery disease underwent elective CABG, between March 2005 and June 2006. All had pulsed wave TDI and mmode imaging obtained from the apex, visualising the tricuspid free wall annulus. Amplitude of TV annulus displacement and RV systolic and diastolic velocities were compared before and 5 days after surgery. Regional mitral annular velocities were also studied for comparison. Results Altogether 21 pts Underwent off- pump CABG. Each subject had a mean 2.6 grafts. All left ventricular regional velocities showed a non significant reduction after surgery. TAM and both systolic (S) and diastolic (E & L) velocities in the RV decreased considerably 5 days after CABG. S 12.6 vs 7.7, E 10.8 vs. 7, A 6.6 vs 9, (p=0.000). The off- pump group had a similar trend with no evidence of preserved RV function compared to the on- pump group. Conclusion Systolic and diastolic RV function, as assessed by DTI and TAM decreased significantly after CABG. TDI can provide a simple and noninvasive qualitative method for assessing and monitoring of RV function after surgery. Off- pump CABG cannot prevent this malfunction.
medical journal of mashhad university of medical sciences
دانشگاه علوم پزشکی مشهد
1735-4013
52
v.
4
no.
2009
203
208
https://mjms.mums.ac.ir/article_5411_eca9acf9651733af278ad0152c98133c.pdf
dx.doi.org/10.22038/mjms.2009.5411
The Relationship of Level of Maternal Serum Copper and Zinc with Neonatal Birth Weight
Hassan
Boskabadi
Assistant Professor of Neonatolog, Neonatal Research Center, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
author
Gholamali
Mamouri
Professor of pediatrics, Neonatalogist, Ghaem Hospital Mashhad University of Medical Sciences, Mashhad, Iran
author
Mehran
Nori
Assistant Professor of Pediatrics,Neonatalogist, Birjand University of Medical Sciences, Birjand, Iran
author
Hosein
Ayatollahi
Assistant Professor of Pediatrics, Patholologist, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
author
Habib
Esmaeily
Assistant professor of Biostatistics, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
author
text
article
2009
per
Introduction Minerals and trace elements such as zinc and copper have significant influence on development and growth of fetus and newborn. The purpose of this study was to determine the relationship between low birth weight and maternal, neonatal zinc, copper status. Materials and Methods This is a case-control study, which was done in Ghaem hospital, Mashhad University over one year from September 2006 to September 2007. The study consisted of 65 infants with birth weight < 2500 gr and 65 infants with ≥ 2500 g and their mothers’ as case and control groups, respectively. Cord and maternal blood samples collected at delivery were analyzed by atomic absorption spectrophotometry for zinc and copper levels. Results Mean serum zinc levels in maternal and the cord blood were 6.35+2.09 mmol/l, 12.77+3.83 mmol/l and 7.57+1.75 mmol/l, 13.18+2.69 mmol/l of case and control groups, respectively (p<0.05). The mean copper levels in maternal and cord blood were 21.82+4.45 mmol/l, 5.12+1.54 mmol/l and 21.19+5.34 mmol/l, 3.65+2.04 mmol/l of control and case groups, respective (p<0.05). Conclusion This study indicated that mothers with the zinc level of less than 6.4 mmol/l were 3.8 time more at risk of having infant with the birth weight of less than 2500 gr. Lower maternal weight, was associated with increased risk of having low birth weight infants
medical journal of mashhad university of medical sciences
دانشگاه علوم پزشکی مشهد
1735-4013
52
v.
4
no.
2009
209
214
https://mjms.mums.ac.ir/article_5412_9f518e18c9084a2a6cf2464705310010.pdf
dx.doi.org/10.22038/mjms.2009.5412
Assessment of Bone Density in Patients before and after Kidney Transplantation
Mohammad Javad
Mojahedi
Professor of Nephrology, Mashhad University of Medical Sciences, Mashhad, Iran
author
Farzaneh
Sharifipour
Assistant Professor of Nephrology, Mashhad University of Medical Sciences, Mashhad, Iran
author
Maryam
Hami
Assistant Professor of Nephrology, Mashhad University of Medical Sciences, Mashhad, Iran
author
Masoud
Saghafi
Associated Professor of Rheumatology, Mashhad University of Medical Sciences, Mashhad, Iran
author
Bita
Dadpour
Specialist in internal diseases (internist), Mashhad University of Medical Sciences, Mashhad, Iran
author
Nayereh
Saadati
Assistant Professor of Rheumatology, Mashhad University of Medical Sciences, Mashhad, Iran
author
text
article
2009
per
Introduction Accentuation of bone loss is one of the most important skeletal complications after transplantation. Early diagnosis and treatment of osteopenia and osteoporosis reduce risk of fractures and prevent the aggravation of it by using corticosteroid after kidney transplantation. Materials and Methods A total of 50 patients that received graft during the research time, 31 of them completed it. They were screened for decreased bone mineral density at baseline, 6 and 12 months after transplantation with dual-energy x-ray absorptiometry (DEXA) of lumbar spine and hip. Results A total of 31 patients [17 (55.8%) female and 14 (45.2%) male] with end stage renal disease entered the study. The mean age of patients in both genders were 39.67±14.5 years (range: 20-67years). Replacement therapy in 24 patients (77.4%) was hemodialysis and in 7 patients (22.6%) was peritoneal dialysis. Before transplantation, the mean of T-score in femoral neck and lumbar vertebra were -0.88±1.19 and-0.37±1.12 respectively, osteopenia was found in 41.9% and 29% of each region. On 6 months after transplantation, the mean of T-score in femoral neck and lumbar vertebra -1.42±0.95 and -1.41±1.36 respectively. Incidence of osteopenia in each region was 83.9% and 64.5% in turn. We tried to examine them in the first year after transplantation, the mean of T-score in femoral neck was-1.13±1.11 and in lumbar vertebra was -1.29±1.33. After 6 months, bone mass reduction was significant (p<0.05), but there was not any significant difference between 6 and 12 months following transplantation (p>0.05). Conclusion Bone losswas highest in the first 6 months after transplantation. Then, treatment was necessary during this period of time.
medical journal of mashhad university of medical sciences
دانشگاه علوم پزشکی مشهد
1735-4013
52
v.
4
no.
2009
215
219
https://mjms.mums.ac.ir/article_5413_d7b7dfcb4c80b7207e8ecc1c298dd78b.pdf
dx.doi.org/10.22038/mjms.2009.5413
Surgical Treatment and Outcomes of 10 Cases with Cardiac Echinococcosis
Ali Reza
Molavipour
Assistant professor of Cardiac Surgery, MashhadUniversity of Medical Sciences, Mashhad, Iran
Mashhad, Iran
author
Ali Reza
Abdollahi
Assistant professor of Cardiovascular Disease, MashhadUniversity of Medical Sciences, Mashhad, Iran
Mashhad, Iran
author
Hassan
Dastani
Assistant professor of Cardiovascular Disease, MashhadUniversity of Medical Sciences, Mashhad, Iran
Mashhad, Iran
author
Maryam
Mojtabavi
Resident in Infectious Diseases,Mashhad University of Medical Sciences, Mashhad, Iran
Mashhad, Iran
author
text
article
2009
per
Introduction Cardiac echinococcosis is an uncommon and potentially fatal complication of hydatid cyst disease, which has an intricate diagnosis and treatment because of various presentation, diverse signs and symptoms, and abundant and sometimes unpredictable complications. This study reviewed the results of surgical treatment of 10 cases of cardiac echinococcosis. Materials and Methods This case of series was done in ten cases of cardiac echinococcosis underwent surgical treatment at Shahid Madani Heart Hospital, Tabriz, in a 12 years period (1992-2004). For collecting data a questionnaire was used and statistical analysis was performed with SPSS software and descriptive statistical methods. Results There were 7 female and 3 male patients (F/M Ratio=1.75/1). The mean age of patients was 24.6 years old. All patients operated through median sternotomy with cardiopulmonary bypass. Surgical treatment included puncture of cyst and sterilization with hypertonic saline solution and total cyst extirpation. There was preoperative mortality and cerebral hydatid cyst occurred in another patient one year later. All patients received albendazol pre- and post-operation. Conclusion According to the results of this study, surgical treatment of cardiac hydatid cyst seems to be a safe approach. It is recommended that patients should receive mebedazole or albendazole for 6 to 24 months after surgery. Reduction of serum levels of antibodies against echinococcus or a negative result signifies a successful treatment.
medical journal of mashhad university of medical sciences
دانشگاه علوم پزشکی مشهد
1735-4013
52
v.
4
no.
2009
244
248
https://mjms.mums.ac.ir/article_5414_464fa3d4da21a0a903254d0e1251de52.pdf
dx.doi.org/10.22038/mjms.2009.5414
Association between Dietary Factors and Obesity in Neishabour School Children
Fereshteh
Baygi
Master of Science (MSc)in Public Health Nutrition,Nutrition and Biochemistry Department,Tehran University of Medical Sciences, Tehran, Iran
author
Ahmad Reza
Dorosty
Associate Professor in Nutrition and Biochemistry Department, Tehran University of Medical Sciences, Tehran, Iran
author
Mohammad Reza
Eshraghian
Professor Associate in Statistic, Statistic and Epidemiology Department, Tehran University of Medical Sciences, Tehran, Iran
author
Arezo
Haghighian Roudsari
Master of Science (MSc) in Nutrition,Faculty of Nutrition Sciences and Food Technology, Shaheed Beheshti University, Tehran, Iran
author
text
article
2009
per
Introduction The prevalence of childhood obesity in developed and developing countries is increasing. Different factors which are associated with childhood obesity should be assessed in each society. This study conducted to determine dietary risk factors of Neishabour school children in winter 2006. Materials and Methods In a cross-sectional study 1471 students aged 6-12 years were selected using two stage cluster sampling. Pupils' height and weight were measured and BMI was calculated. Obesity was defined as having a BMI>= 95th percentile of Iranian reference; in this way, 114 students were selected as case group and control group were students having 15th =<BMI=<85th. Control group was matched with case by age, school and classroom. Twelve students of control group were omitted because of not willing to enter the study (control=102 students). To find out dietary risk factors associated with childhood obesity, in each instance we interviewed the mother and the child for filling 24 hour dietary recall and food frequency questionnaire. Results Results showed that the average of daily calorie intake in cases was significantly higher than the control group (2413.1±542.2 vs. 1762.1±411.7; p<0.001). Daily energy intake from carbohydrate, protein and fat considerably different between two groups (p<0.001). The Frequency of cola, chips, puffs, chocolate, natural fruit juice and fast foods was remarkably different between the case and control groups (p<0.001). Conclusion Preventive actions are necessary to be planned for childhood obesity.
medical journal of mashhad university of medical sciences
دانشگاه علوم پزشکی مشهد
1735-4013
52
v.
4
no.
2009
226
232
https://mjms.mums.ac.ir/article_5415_4c4b634c23301911a126fa32ddba5f55.pdf
dx.doi.org/10.22038/mjms.2009.5415
A Survey of Otomycosis in Eastern Azarbaidjan
"Research Center of Tropical & Infectious Diseases,
TabrizUniversityof Medical Sciences"
Abdol-Hasan
Kazemi
Associated Professor of Molecular Medical Mycology, Tabriz University of Medical Sciences,Tabriz, Iran
author
Mohammad
Nejadkazem
Associated Professor of ENT, TabrizUniversity of Medical Sciences,Tabriz, Iran
author
Ghodrat
Mohamadi
Associated Professor of ENT, TabrizUniversity of Medical Sciences,Tabriz, Iran
author
Mir Rahim
Sayyah Melli
Associated Professor of ENT, TabrizUniversity of Medical Sciences,Tabriz, Iran
author
Samad
Ghiasi
Associated Professor of ENT, TabrizUniversity of Medical Sciences,Tabriz, Iran
author
Masoud
Naderpour
Associated Professor of ENT, TabrizUniversity of Medical Sciences,Tabriz, Iran
author
Abbas Ali
Jafari
Associated Professor of Medical Mycology, Yazd, Iran
author
Poneh
Pasha Pour
Master of Science (MSc), School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Science, Tabriz, Iran
author
Ghazaleh
Davarnia
Master of Science (MSc), School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Science, Tabriz, Iran
author
Mahdi
Mami Zade
General Practitioner
author
Najibeh
Akbari Rahnemaye
Tutor, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
author
Iran
Noa Khahi
Master of Science (MSc), School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Science, Tabriz, Iran
author
text
article
2009
per
Introduction Otomycosis (Otitis externa) is a fungal infection of the external ear canal with only a few studies about its real frequency in Iran. To evaluate otomycosis frequency and characteristics in patients with clinical suspicion of external otitis the present study was carried out in eastern Azarbaidjan (North – West of Iran) during 2006-2008. Materials and Methods A total of 53 patients were assigned to mycological diagnosis (direct microscopic examination and culture). Clinical samples of suspected patients were studied for laboratory identification in direct microscopy and cultured in specific mediums for the determination of their causative fungi. Results Over all 43 fungal isolates [14 male (33%) and 29 female (67%)] were taken from 53 patients suspected of otomycosis. The mycose was more prevalent in 20-40 years age group in both sexes. The most common pathogen was Aspergillus niger (40 cases), followed by A fumigatus (3 cases) and Candida albicans (2 cases). In clinical samples of some cases two different fungi were isolated at the same time. Conclusion Saprophytic molds were the main etiologic agents of otomycosis, and A. niger was the prime causal agent. Infection in 20–40 age groups had the most prevalence and otomycosis among females was determined more than males. This study provided useful information on the prevalence, causative agents and health implications of otomycosis, as an infection grossly neglected in studied environment.
medical journal of mashhad university of medical sciences
دانشگاه علوم پزشکی مشهد
1735-4013
52
v.
4
no.
2009
233
238
https://mjms.mums.ac.ir/article_5416_03c74a6651b4d4f99afada143bf2866b.pdf
dx.doi.org/10.22038/mjms.2009.5416
Analysis of Mortality in A Burn Center
Ezatolah
Rezaei
Assistant Professor of Plastic Surgery, Mashhad University of Medical Sciences, Emam Reza HospitalMashhad, Iran
author
Hossein
Safari
Resident of Infectious DiseaseMashhad University of Medical Sciences, Mashhad, Iran
author
Seyed Mohammad
Motamedolshariati
Assistant Professor of Plastic Surgery, Mashhad University of Medical Sciences, Emam Reza HospitalMashhad, Iran
author
Monavar
Afzal Aghaei
Specialist of SocialMedicine, Mashhad University of Medical Sciences
author
text
article
2009
per
Introduction Burn injury is a disaster. Burn injuries still produce a significant morbidity and mortality in Iran. Imam Rreza hospital burn center in Khorasan, serves 5420000 people in an area of 302000 km2. The most of the people injured are from low socioeconomic levels. The aim was to make a critical analysis of mortality in our burn center with a view to finding possible ways of improving the care given to our patients and suggesting ways of reducing mortality. Materials and Methods This study was carried out to analyze the epidemiology of 866 patients who died in Imam Reza hospital burn center during the 4 years from 15 march 2003 to 15 march 2007. During this 4-year period, 4697 patients were hospitalized. Eight hundred and eighty-six of the patients (18%) died, of whom 322 were male and 544 female. The age and sex of patients, extent of injury, season of occurrence, and duration of admission to hospital before death, as well as the possible cause(s) of death, were collected from the patient folders. The statistical analysis was performed using SPSS soft ware. p value less than 0.05 was considered as statistically significant. Results The overall incidence rates of hospitalization and death were 21.6 and 3.9 per 100 000 persons in each year. The mean age for accidental patients was 30.8 years, and for self-inflicted burns was 28.3 years. In the accidental patients, the BSA of the burns ranged from 5 to 95%, with a median of 70%. In the self-inflicted patients, the median of BSA was 90%. The median hospital stay was 7 days with a range of 1–96 days for burned patients. The majority of accidental burns was caused by Flammable liquid (47%) and of self inflicted burns by kerosene (97%). Conclusion The highest mortality was observed in the age group 11-30 years. Factors associated with an increase in mortality were suicidal burns and burn size.
medical journal of mashhad university of medical sciences
دانشگاه علوم پزشکی مشهد
1735-4013
52
v.
4
no.
2009
239
243
https://mjms.mums.ac.ir/article_5417_d49c1ed753bde2edffd388156e904ff3.pdf
dx.doi.org/10.22038/mjms.2009.5417
Headache in Multiple Sclerosis
Fereshteh
Ashtari
Associate Professor ofNeurology, Isfahan University of Medical Sciences, Isfahan, Iran
author
Ahmad
Chitsaz
Associate Professor ofNeurology, Isfahan University of Medical Sciences, Isfahan, Iran
author
Mehdi
Shishegar
Resident of Neurology, IsfahanUniversity of Medical sciences, Isfahan,Iran
author
text
article
2009
per
Introduction Multiple Sclerosis (MS) is a common neurological disease in young adults with variable clinical symptoms and signs. Many of MS patients experience headache. This study was done to evaluate the prevalence of headache in MS patients. Materials and Methods This descriptive cross-sectional study was carried out in MS clinics affiliated to Isfahan university of Medical Sciences in the first six months of 1380. For each patient a questionnaire was filled according to history and examination, and the data was analyzed by SPSS program. Results From 100 patients, 67% had headache and 86.6% of them were women .Tension headache in 47.7% and migraine headache in 34.3% was reported. Of 100 patients, 23 of them had migraine headache, 36 patients had history of headache before the onset of MS, whom in 52.8% severity of headache was increased. Of patients 10.4% had headache at the onset of MS and in 6.8% headache was the first symptom of MS. The neurological signs and symptoms were presented after headache. Conclusion According to this study different types of headaches are common in MS and the migraine type is more common than in general population.
medical journal of mashhad university of medical sciences
دانشگاه علوم پزشکی مشهد
1735-4013
52
v.
4
no.
2009
244
248
https://mjms.mums.ac.ir/article_5418_e272e3e930443b8c3577f04ab2f69b1f.pdf
dx.doi.org/10.22038/mjms.2009.5418
Recognition of Special form of Amphetamine Acquaintance in Iran and Presentation of 4 cases with Neurovascular Complication
Karim
Nikkhah
Associated Professor of Neurology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
author
Payam
Sasannejad
Assistant Professor of Neurology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
author
Mohammad
Ardom
Pharmacologist, Mashhad University of Medical Sciences, Mashhad, Iran
author
Reza
Kiani
Neurologist, Mashhad University of Medical Sciences, Mashhad, Iran
author
text
article
2009
per
Introduction Ecstasy and crystal are recently new most widely abused illegal drugs in Iran. Ecstasy/MDMA abuse may cause acute complications that have fatal consequences. Cases report Pt 1: A 26 year old who referred to emergency room due to acute paraplegia and finally died with cardiac arrest. Pt 2: A 45 year old woman who came with seizure disorder and unconsciousness. Finally she died due to cardiac arrest. Pt 3: A 32 year old man was admitted due to acute flaccid paraplegia. He had diffused skin rash due to vasculitis. The patient died despite of supportive cares. Pt 4: A 23 year old man who referred to neurological ward because of generalized tonic-clonic seizures following Crystal and Ecstasy abuse. The patient was discharged after 4 days with good general conditions. Conclusion Unfortunately recently, the rate of Ecstasy and Crystal drugs abusers in Iran have increased. This paper notify about the neurological side effects of these drugs.
medical journal of mashhad university of medical sciences
دانشگاه علوم پزشکی مشهد
1735-4013
52
v.
4
no.
2009
249
252
https://mjms.mums.ac.ir/article_5419_2d24caed2c068eedbafec7bcd00931c9.pdf
dx.doi.org/10.22038/mjms.2009.5419