The effect of sertraline on CRP of depressed hemodialysis patients
narges
Sadat Zahed
Department of nephrology ,shahid beheshti university of medical science, Loghman hakim hospital
author
Marjan
sharifi
resident of internal medicine, ,shahid beheshti university of medical science
author
Maryam
Ghosami
resident of internal medicine, ,shahid beheshti university of medical science
author
text
article
2015
per
Introduction:Depression is the most prevalent psychological problem among HD patients, associated with higher mortality in these patients. Inflammatory factors have been reported to play an important role in the pathogenesis of depression. It has been also found that Associated depression has been correlated with inflammatory status in these patients. Sertraline, an antidepressant with selective inhibition of serotonin reuptake, decreases serum level of inflammatory factors in patients with depression. This study was designed to assess the effect of sertraline on serum concentration of CRP, Hb & Albumin of depressed hemodialysis (HD) patients.Method: During a clinical trail, 35 depressed HD patient with CRP>5 allocated to receive sertraline for 12 weeks. Patients’ depression was assessed using Beck Depression inventory second edition (BDI-II). Biochemical parameters (hemoglobin, serum albumin, etc.) and CRP levels were measured at baseline and at weeks 4 and 8 and 12 of study.BDI-II score evaluated before and after 12 Weeks of treatment with sertraline.Results: Sertraline significantly improved depression symptoms in HD patients. At the end of the study, BDI-II scores have significantly changed from baseline(P value=0.001) and Serum level of CRP has Significantly decreased at week 12 comparing with level at initiation of the study. (P=0.001)Not significantly change in Hemoglobin and serum albumin concentration and weight has been observed (P=0.995 and P=0.328)Conclusion: Sertraline has significantly decreased CRP level and could be a promising strategy to reduce the systemic inflammation and to treat depression in HD patients.
medical journal of mashhad university of medical sciences
دانشگاه علوم پزشکی مشهد
1735-4013
58
v.
9
no.
2015
481
488
https://mjms.mums.ac.ir/article_6502_7c41a137327b9a7546cad2d8df97648e.pdf
dx.doi.org/10.22038/mjms.2015.6502
The effect of Eight weeks aerobic training on Resistin levels and cardio respiratory fitness in sedentary middle-aged women
Mehrdad
Fathei
Associate Professor in Sport Physiology, Faculty of Physical Education and Sports Sciences, Ferdowsi University of Mashhad, Mashhad-Iran
author
Keyvan
Hejazi
PhD student of Physical Education and Sport Sciences, Ferdowsi University of Mashhad, Mashhad, Iran
author
Mojtaba
Kiani gol
3- MS.c of sport physiology, Faculty of Physical Education and Sports Sciences, Hakim Sabzevari, Sabzevar, Iran
author
text
article
2015
per
Introduction: One of the most important inflammatory cytokines that may be involved in the pathogenesis of cardiovascular disease is resistin. The aim of this study was to investigate the effect of eight weeks aerobic training on Resistin levels and cardio respiratory fitness in sedentary middle-aged women.
Materials and Methods: 21 healthy elderly women were selected by convenience sampling method and were randomly assigned to control (n=11) and experimental (n=10). The program training include: 60 min per session, 3 times per week for 8 weeks participate in aerobic exercise with 50-70 HRR%. Pre and post of aerobic exercise, resistin levels and cardio respiratory fitness evaluated. The average and standard deviation of data were calculated after checking the noremal distribution using Kolmogorov-Smirnov test and Homogeneity of variance method and then examined by comparison of means within and between means groups Paired-Samples and Independent t-test was used respectively. Statistical significance was assigned at P < 0.05 for all analysis.
Results: Eight weeks aerobic exercise lead to reduce of resistin levels in elderly women. Amount of cardio respiratory fitness increased significantly. The variations of between groups in weight, BMI and Vo2max have differences.
Conclusion: Eight weeks of aerobic training resulted in improved levels of resistin and cardio respiratory fitness in middle-aged women and it can help to reduce the risk of cardiovascular disease
medical journal of mashhad university of medical sciences
دانشگاه علوم پزشکی مشهد
1735-4013
58
v.
9
no.
2015
489
497
https://mjms.mums.ac.ir/article_6503_1142e3d636a3278a16369173054e43a5.pdf
dx.doi.org/10.22038/mjms.2015.6503
Investigation on the validity of fasting blood glucose and glucose tolerance test in fifth days after kidney transplantation for anticipating diabetes mellitus
Mahin
Ghorban sabagh
Assistant Professor of Nephrology, Kidney Transplantation Complications Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
author
Mostafa
Jafari
Assistant Professor of Internal Medicine, Faculty of Medicine , Mashhad University of Medical Sciences, Mashhad, Iran.
author
Zahra
Lotfi
Assistant Professor of Nephrology, Kidney Transplantation Complications Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
author
Reza
Javidi
Medical student, Faculty of Medicine, Mashhad university of Medical Science, Mashhad, Iran
author
text
article
2015
per
Introduction: Kidney transplantation is the best replacement therapy for patients with end stage renal disease at present. Cardiovascular disease is the most important cause of mortality among these patients. Also chronic allograft nephropathy is to some extent a manifestation of cardiovascular pathology. Diabetes mellitus is the most influencing factor both in cardiovascular disease and chronic allograft nephropathy. Prediction and timely detection of new onset diabetes after kidney transplant can help therapies in appropriate management and manipulation of modifiable risk factors of this phenomenon.
Method: The present study has been performed upon 66 chronic renal failure patients undergone kidney transplantation during a 4 months period at Imam Reza (p.b.u.h) university hospital of Mashhad –IRAN. On day 5 and at month 6 post transplantation, fasting blood glucose measured and a 75 g , glucose tolerance test performed. Another fasting blood glucose recorded at week 12. The immunosuppression regimen was the same for all. Exclusion criteria were: History of Diabetes mellitus, Graft rejection, Hepatitis C, Infection and need for immunosuppressive drug modification. Sensitivity and specificity analysis test used to evaluate the ability of day 5-post transplantation fasting blood glucose and glucose tolerance test to predict the occurrence of post transplantation diabetes mellitus. (PTDM)
Results: 6 out of 66(9.3%) patients had day 5 fasting blood glucose > 126 mg/dl while the remaining 60 had values <100 mg/dl . The same 6 patients had fasting blood glucose > 126 mg/dl six months post transplantation and indeed developed PTDM. Therefore sensitivity and specifity of 5th day fasting blood glucose as a predictor Of PTDM equals one (100% ) based on our results. The results were similar for glucose tolerance test .
Conclusion: Day 5 post transplantation fasting blood glucose is a good predictor of PTDM and can be used as a modifier to individualize the management of kidney transplant recipients.
medical journal of mashhad university of medical sciences
دانشگاه علوم پزشکی مشهد
1735-4013
58
v.
9
no.
2015
498
504
https://mjms.mums.ac.ir/article_6507_478c22a44d2e7d502c3a30afd0fce243.pdf
dx.doi.org/10.22038/mjms.2015.6507
Effect of diclofenac suppository in bleeding and pancreatitis incidence rate after ERCP in patients with common bile duct stones
Abbas
Esmaeilzadeh
Assosiat profssor Gastroentrology. Imam Reza Hospital . Mashhad University of Medical Sciences.
author
Hadi
Bagheri Hosseini
Eellow of Gastroentrology. Imam Reza Hospital. Mashhad University of Medical Sciences.
author
Seied
mehdi Pakdaman
– Eellow of Gastroentrology. Neishabour University of Medical Sciences
author
Jamshid
Jamali
Student PhD in biostatistics. Shiraz University of Medical Sciences
author
text
article
2015
per
Background
Endoscopic Retrograde CholangioPancreatography (ERCP) as a diagnostic and therapeutic tool for biliary tract and pancreatic diseases is associated with many complications such as pancreatitis, bleeding, perforation, and cardiovascular consequences. Recent surveys have shown that the use of non- steroid anti-inflammatory drugs before ERCP could reduce risk of pancreatitis after ERCP. This study aimed to evaluate the effect of diclofenac suppository in reducing bleeding and pancreatitis after ERCP in patients with common bile duct stones.
Methods:
This double-blind randomized clinical trial study was performed on 160 patients with bile duct stones that were needed to ERCP during the period January-September 2013. Patients were randomly divided into two groups of 80 patients treated with diclofenac suppository (case group) and Acetaminophen suppository (control group). The incidence of pancreatitis and bleeding after ERCP were evaluated based on clinical signs and laboratory findings. Data analysis was performed by SPSS statistical software and statistical tests of Kolmogorov-Smirnov, chi square and Fisher's exact test, independent student's, and Mann–Whitney U test. A P-value of less than .05 was considered significant.
Results:
The mean age of patients was 61.24 ± 17.00 years and female to male ratio was 89 to 71 that difference between two groups were not statistically significant. In patients taking diclofenac suppository and acetaminophen 9 (11.3%) and 11 (13.8%) cases had mild pancreatitis, respectively. In the control group 2 cases (5.2%) and in case group any case had severe pancreatitis. Twenty-one patients (26.3%) receiving acetaminophen and 28 (5/35%) receiving diclofenac suppository had bleeding while cutting sphincter (Fisher's exact test=1.54; p-value=0.488).
Conclusions:
The results of this study showed that Diclofenac administered after ERCP had no effect on the incidence of pancreatitis and bleeding complications.
medical journal of mashhad university of medical sciences
دانشگاه علوم پزشکی مشهد
1735-4013
58
v.
9
no.
2015
505
515
https://mjms.mums.ac.ir/article_6512_5da1c5dbccbff3b78a6359af50a34379.pdf
dx.doi.org/10.22038/mjms.2015.6512
Survey the cutaneous leishmaniasis prevalence in Mashhad during the past twenty years (1995 – 2014) and the effect of environmental risk factors on that
Shahab
Galavizade
Mashhad University of Medical Sciences, Mashhad,Iran
author
Abdolmajid
Fata
Mashhad University of Medical Sciences, Mashhad, Iran
author
Vida
Vakili
Mashhad University of Medical Sciences, Mashhad, Iran
author
Mehdi
Zarean
Mashhad University of Medical Sciences, Mashhad, Iran
author
text
article
2015
per
Introduction: Leishmaniasis is a parasitic infectious disease, which is caused by a protozoan called Leishmania. It appears in three clinical forms including Cutaneous Leishmaniasis (CL), Mucocutaneous Leishmaniasis (MCL), and Visceral Leishmaniasis (VL). Anthroponotic Cutaneous Leishmaniasis formerly called urban form mostly observed in cities while Zoonotic or rural form mostly seen in villages. Climatic factors have effective influence on the incidence and prevalence of CL. The purpose of this study was to investigate the present status of CL in the city of Mashhad as one of the important centers of the disease and the effects of bioclimatic factors on its prevalence during the past 22 years (1992 – 2014). Methods: In this epidemiological study, the raw data of confirmed cases with CL were collected from 5 health centers of Mashhad University of Medical Sciences. The climatic data were also obtained from the Meteorological Office and then analyzed using Excel software and Pearson correlation test. Results: During 20 years (1992–2014), 68958 cases of CL were diagnosed at Mashhad health centers, the highest rate of CL was observed among the patients who had referred to the mentioned health centers during the cold seasons every year. No significant relationship was found between sunny hours and wind speed and CL, but there was a remarkable correlation between precipitation rate, seasonal temperature, and humidity percentage with the prevalence of the disease. The highest rate of CL infection was observed during 2000-2001with higher prevalence of ACL. Conclusion: Climatic factors have remarkable influence on the prevalence of ACL in this city. Most of the patients were found to live at the marginal areas of the city with a non-immune population, low municipal services, new constructions, and sources of the disease.
medical journal of mashhad university of medical sciences
دانشگاه علوم پزشکی مشهد
1735-4013
58
v.
9
no.
2015
516
522
https://mjms.mums.ac.ir/article_6513_704f99008268be30fa42a27175240da5.pdf
dx.doi.org/10.22038/mjms.2015.6513
Evaluation of organisms causing infectious endocarditis in children during 10 years
Hasan
Mottaghi Moghadam
Associate of pediatric cardiologist, pediatric department in Emam Reza hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
author
Mohsen
Horri
Associate of pediatric cardiologist, pediatric department in Emam Reza hospital, Mashhad University of Medical Sciences, Mashhad, Iran
author
Saghi
Elmi
Pediatrician, pediatric department in Emam Reza hospital, Mashhad University of Medical Sciences, Mashhad, Iran
author
Nasrin
Motevalli Haghi
Pediatrician, pediatric department in Emam Reza hospital, Mashhad University of Medical Sciences, Mashhad, Iran
author
Reza
Erfani Sayyar
Anesthesiologist , Intensive Care Unit (ICU) department in Emam Reza hospital, Mashhad University of Medical Sciences, Mashhad, Iran
author
Shaghayegh
Rahmani
General physician, health investigation center, Mashhad University of Medical Sciences, Mashhad, Iran
author
Sam
Elmi
General physician, health investigation center, Mashhad University of Medical Sciences, Mashhad, Iran
author
text
article
2015
per
Introduction : : Infective endocarditis is a disorder with high mortality and morbidity in children specially in whom with Congenital Heart Disease(CHD) .The target of our study is a description of the factors affecting pediatric Infective endocarditis particularly in whom with CHD in Mashhad.
Method : this cross-sectional study includes 19 patients less than 18 years old with endocarditis hospitalized in the Department of Pediatric Cardiology( University of Mashhad Medical Sciences) between 1381 to1391.Clinical symptoms, risk factors, underlying heart disease ,laboratory- echocardiogeraphic results were studied. Finally data were analyzed by using SPSS 16 software.
.
Results: Endocarditis were seen in 21.1% of children with previous underlying infectious disease. According to results of blood cultures Staphylococcus aurous was the most common crime ( 21%).Each of Coagulase-negative staphylococci, Staphylococcus epidermidis and gram-negative cocci were seen in just one patient.10.6% of children had Umbilical /vein catheter history. The most common underlying factor was congenital heart disease (47.7%). Having history of surgery in 7(36.8%) patients due to CHD before endocarditis were detected .Vegetation were resected in 2 (10.5%)children as a treatment after endocarditis .There was no significant difference between time of surgery and microbial crime(p-value= 0.069). Cardiac vegetation was seen in 18 children(94.7%).One child (5.2%) died.
Conclusion: According to irrecoverable effects of infectious endocarditis in children, it seems that strong clinical suspicion also considering of underlying causes and negative results of blood cultures , especially in children with congenital heart disease can be crucial in reducing mortality and complications of infectious endocarditis.
medical journal of mashhad university of medical sciences
دانشگاه علوم پزشکی مشهد
1735-4013
58
v.
9
no.
2015
523
530
https://mjms.mums.ac.ir/article_6515_6ebbc965c7e0e217f592185d4861c59e.pdf
dx.doi.org/10.22038/mjms.2015.6515
Epidemiological characteristics and trend of incidence of human brucellosis in Razavi Khorasan province
Soheil
Hashtarkhani
Master student, Department of medical informatics, Faculty of Medicine, University of Mashhad Medical Science, Mashhad, Iran
author
Masoome
Akbari
Master student, Department of medical informatics, Faculty of Medicine, University of Mashhad Medical Science, Mashhad, Iran
author
Lida
Jarahi
Assistant Professor, Department of Social Medicine, Faculty of Medicine, University of Mashhad Medical Science,Mashhad, Iran
author
Kobra
Etminani
Assistant Professor, Department of Medical Informatics, Faculty of Medicine, University of Mashhad Medical Science, Mashhad, Iran
author
text
article
2015
per
Background & Purpose: Brucellosis is a transmissible disease between humans and animals that is transmitted through infected animals and their products. Razavi Khorasan which is classified as a high incidence province, considered as one of the notable areas for controlling the disease. The aim of this study is to identify epidemiological characteristics of the disease in Razavi Khorasan.
Materials &Methods: Data on 5743 cases in Razavi Khorasan (affiliated to Mashhad Medical University) during 5 years were analyzed.
Results: The incidence of the disease in the province is 26 out of 100,000 people which the incidence rate in Daregaz,Takhtjolge and Roshtkhar was much higher. In the first 3 years of study the disease incidence was ascending and in last 2 years it was descending and from May to August the prevalence was more than other months.85% of patients were rural and 15% were urban. 56.9% were male and 43.1% female. Household and farmer-rancher were the most common jobs. Average age of patients was 33.4 ±18.1 year. 77.2% had consumption of unpasteurized dairy products which milk (91.4%) and cheese (21.4%) had the highest consumption. The most common symptoms were fever (79%) and anorexia (47.5%). A significant relationship between location and both livestock vaccination history and also family history, was found.
Conclusion: Because of higher incidence rate of the disease in Daregaz, Takhtjolge and Roshtkhar, and also young people aged 10 to 30 years and villagers, It’s need to control the disease in these groups.
medical journal of mashhad university of medical sciences
دانشگاه علوم پزشکی مشهد
1735-4013
58
v.
9
no.
2015
531
538
https://mjms.mums.ac.ir/article_6516_e726ea00ed43972a65b5a46eb97f6c8d.pdf
dx.doi.org/10.22038/mjms.2015.6516
Comparison of frequency of varicose veins and occupational risk factors between clinical and administrative personnel
Farzaneh
Rahim pour
Assistant Professor , Occupational Medicine Department, Mashhad University of Medical Sciences, Mashhad, Iran
author
Laya
Afshari Saleh
Assistant Professor , Occupational Medicine Department, Mashhad University of Medical Sciences, Mashhad, Iran
author
Negar
Assadi
Associate Professor, Environmental health Department, Mashhad University of Medical Sciences, Mashhad, Iran
author
Lida
jarahi
Lida jarahi
Assistant Professor, Social medicine Department, Mashhad University of Medical Sciences, Mashhad, Iran
author
Ehsan
Rafee manesh
Assistant Professor , Occupational Medicine Department, Mashhad University of Medical Sciences, Mashhad, Iran
author
ali
Pourakbar
Department of Gastroenterology and Hepatology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, IR Iran
author
Ssamaneh
esfandiari
Department of occupational medicine , mashhad university of medical science ,mashhad Iran
author
text
article
2015
per
Background: The aim of this study was to find out the prevalence and risk factors of varicose veins in hospital staffs.
Method: This cross sectional study was performed in Qaem and Emam Reza hospitals. 240 hospital staffs were selected by random sampling method. Inclusion criteria were work experience more than3 years and satisfaction for participation in the study. All staffs underwent physical examination and history taking. Data were analyzed with SPSS version 16 .
Results: From 240 hospital staffs 132 persons (55%) had varicose veins of lower limb. Incidence of varicose veins was significantly higher in clinical ward workers (p=0/001). Female sex was one of the most important risk factor of varicose veins occurrence. Odds ratio of varicose vein in clinical personnel was 3/7 . In clinical personnel group the risk of greater grade of varicose veins was more in nurse's aides group (OR =3/4).Between grade of varicose vein and shift working was significant correlation (p=0/018).
Conclusion: This study show that occupational factors such as prolong standing ; shift work and lifting have significant role in development of varicose veins in lower limbs.
medical journal of mashhad university of medical sciences
دانشگاه علوم پزشکی مشهد
1735-4013
58
v.
9
no.
2015
539
546
https://mjms.mums.ac.ir/article_6517_727a5bb478effcf7e51925d8dc542873.pdf
dx.doi.org/10.22038/mjms.2015.6517