The relationship between the amount of proteinuria and interstitial fibrosis/tubular atrophy in kidney transplant recipients

Document Type : Research Paper

Authors

1 Assistant Professor, Department of Nephrology, Mashhad University of Medical Sciences, Mashhad, Iran

2 Faculty Member, Islamic Azad University, Mashhad Branch, Mashhad, Iran

Abstract

Introduction: The amount of proteinuria is a predictor of renal outcome in kidney transplantation. In this study we investigated the relationship between the amount of proteinuria and interstitial fibrosis /renal atrophy (IFTA) in biopsy samples taken from kidney transplantation.
Materials and Methods: In total 60 patients with proteinuria from November 2013 to May 2017 in Montaseriyeh hospital, transplant center of Mashhad, Iran were investigated. For all patients, Biopsy of kidney transplantation was performed. Then, the relationship between proteinuria and IFTA was evaluated. 
Results: Among 60 patients 25% had nephrotic range and 75% had sub- nephrotic range proteinuria. According to the severity of fibrosis we divided the patients into three categories: mild (IFTA40). The prevalence of IFTA was mild in 57.8%, moderate in 32.8% and severe in 9.4%. According to the results of this study, there were relationships between amount of proteinuria and severity of fibrosis. Patients with nephrotic range proteinuria had more fibrosis (P<0.005).
Conclusion: Understanding the symptoms associated with fibrosis in transplanted kidney, may be useful in early diagnosis of development of fibrosis.

Keywords

References

References
 
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Medical Journal of Mashhad university of Medical Sciences
Volume 61, Issue 6
May and June 2019
Pages 1288-1293

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