Comparison Efficacy of Doxycycline and Azithromycin and Clarithromycin in the Treatment of Chronic Bacterial Rhinosinusitis
Farhad
Farokhpey
Assistant professor of Ear, Nose and Throat, School of Medicine, Islamic Azad University of Tonekabon, Tonekabon, Iran
author
Niloofar
Niabati
Specialist of Ear, Nose and Throat, Emam Sajjad Hospital, Ramsar,Iran
author
Mohamad
Amri Maleh
General Physician, School of Medicine, Islamic Azad University of Tonekabon, Tonekabon, Iran
author
Melodi
Omraninava
Assistant professor of Infectious Disease, School of Medicine, Islamic Azad University of Tonekabon, Tonekabon, Iran
author
Mohammad
Mansoursaravi
Radiologist, School of Medicine, Islamic Azad University of Tonekabon, Tonekabon, Iran
author
Parviz
Amri Maleh
Associated professor of Anesthesiology , School of Medicine, Babil University of Sciences, Babol , Iran
author
text
article
2014
per
Introduction: Chronic sinusitis is one of the most common causes of referring to physician and creates longterm discomfort for people. The common bacterial organisms include: Streptococcus pneumonia, Hemophillous influenza, Moraxella catarrhalis, Staphylococcus aurous, biofilm and superantigen produced by some of these bacteria should be considered. This study aimed to compare the efficacy of Doxycycline, Azithromycin and Clarithromycin in the treatment of chronic bacterial rhinosinusitis. Materials and Methods: In this clinical trial, 55 patients with a mean age of 36 years with chronic bacterial rhinosinusitis who were documented clinically and by imaging (CT Scan), were treated in three groups with Doxycycline (100mg BD), Azithromycin (8mg/kg BD), and Clarithromycin (500mg BD). The patients were followed by clinical signs, symptoms and imaging. Data were analyzed by SPSS software and Chi Square, Anova and T test. Results: At the end of treatment, Doxycycline’s treatment success rate was higher than Azithromycin and Clarithromycin (the clinical cure rates respectively were 73 % versus 57% and 40%, and CT Scan cure rate results respectively were 70% versus 33% and 25%). Conclusion: The results of present study indicated that the Doxycycline in the treatment of chronic bacterial rhinosinusitis was more effective than Azithromycin and Clarithromycin in clinical response and improved CT Scan results. Acknowledgment: Thanks to Mr. Bahrami for data analysis, Mr.Einollah Alipur, Ms. Darwish to collect samples , the University of Medical Sciences and the staff of CT Scan ,Shahid Rajaee &Emam Sajjad Hospital clinics of Ramsar for the necessary cooperation in this research project.
medical journal of mashhad university of medical sciences
دانشگاه علوم پزشکی مشهد
1735-4013
57
v.
7
no.
2014
814
821
https://mjms.mums.ac.ir/article_3581_fb6e3bdd3874c151b7da09dc5677559b.pdf
dx.doi.org/10.22038/mjms.2014.3581
A survey of prevalence of colorectal chemotherapy side effects
Mahboobe
Sadeghi Ivari
Radiation Oncologist, faculty of medicine, solid tumor treatment research centre, Mashhad University of medical sciences,
author
Amir
Aldavood
Associate professor of radiation oncology, faculty of medicine, solid tumor treatment research centre, Mashhad University of medical sciences,
author
Roham
Salek
Associate professor of radiation oncology, faculty of medicine, solid tumor treatment research centre, Mashhad University of medical sciences
author
text
article
2014
per
Introduction: The aim of this study was to give an overlook to the variety of chemotherapy regimens prescribed for colorectal adenocarcinoma and their side effects. Colorectal carcinoma is one of the mostly common cancers in our region and most experiences of physicians are based on non-native studies. To our knowledge this is the first such a study, although including a limited group of patients for reviewing the treatment. Materials and methods: We selected a group of 109 patients having colon and rectum cancer undergoing chemotherapy with different regimens during the study period, that were referred and treated consecutively. Some of the side effects of treatments were followed-up and registered prospectively. Results: After 468 courses of chemotherapy and recording the side effects during the first six courses of treatment, 55 cases (11.6%) had grade 3 or 4 of complications. The most prevalent regimen was FOLFOX4 (37.6%) and then CapeOX (26.9%). The most common major complication was neutropenia (5.3%) and then gastrointestinal complications including nausea (1.5%) and diarrhea (1.3%). Conclusion: In this study none of the factors of gender, age, ethnicity, performance status, the stage of disease, the tumor location and the kind of chemotherapy regimens had statistically significant effect on severity of the side effects.
medical journal of mashhad university of medical sciences
دانشگاه علوم پزشکی مشهد
1735-4013
57
v.
7
no.
2014
822
828
https://mjms.mums.ac.ir/article_3607_f93c57a63cbba4ac29317caaa4cf5503.pdf
dx.doi.org/10.22038/mjms.2014.3607
Survey of clinical manifestations in Henoch Schönlein purpura in follow up
Mohammad Hassan
Moradinejad
Pediatric Rheumatologist, Teh Department of Pediatrics, Children’s Medical Center, Pediatric Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran.
author
Vahid
Ziaee
Associate Professor of Pediatric Rheumatology, Pediatric Rheumatology Research Group, Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran
author
Sayed Mahdi
Marashi
Forensic medicine and Clinical Toxicology Specialist, Health policy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
author
Zeynab
Nasri Nasrabadi
Resident of pediatrics. Department of Pediatrics, Children’s Medical Center, Pediatric Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran
author
text
article
2014
per
Introduction: Henoch Schönlein purpura (HSP) is a small vessel leukocytoclastic vasculitis that generally occurs in children, and 90 percent of cases are under 20 years old. The aim of this study was to examine the clinical manifestation in follow-up of Iranian children affected with Henoch Schönlein purpura (HSP). Materials and methods: In a case study during 2012, 155 children with a diagnosis of HSP treated in children’s medical center hospital from September 2008 to September 2011 were included. All patients were re-examined for new symptoms as well as complications. RESULTS: the most cases of HSP aged among 3 and 6 yaers old and it was slightly more frequent in boys. At onset, the most common presenting symptoms, were purpura (85.5%), gastrointestinal manifetations (61.9%) articular involvement (61.3%), and in the course of disease were purpura (96.1%), constitutional symptoms (84.5%) and articular involvement (74.2%). Based on the follow-up conducted in 2012, a statistically significant correlation was observed only in renal complications and increasing age of patients (P=0.007) CONCLUSION:. Because renal failure is a major complication of HSP, it is recommended that all patients with proteinuria in the acute phase, have a blood pressure examination and urine-analysis once a year. ACKNOELEDGEMENT: The authors declare that there are no conflicts of interest for this study.
medical journal of mashhad university of medical sciences
دانشگاه علوم پزشکی مشهد
1735-4013
57
v.
7
no.
2014
829
834
https://mjms.mums.ac.ir/article_3606_01d66f4210dfa4a1abfc8e57bd5f8c70.pdf
dx.doi.org/10.22038/mjms.2014.3606
Correlation of Systemic Lupus Erythematosus disease activity index (SLEDAI) with serum uric acid level in lupus patients
Abbasali
Zeraati
Associate Professor of Nephrology, Kidney transplantation Complications Research Center, Imam Reza Hospital ,Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
author
Zhaleh
shariati sarabi
AssociateProfessor of rheumatology,Mashhad University of Medical Sciences, Department of Internal Medicine, Imam Reza Hospital , Mashhad, Iran
author
Amir
Davoodabadi Farahani
Resident of internal medicine, Mashhad University, Mashhad, Iran
author
Zahra
mirfeyzi
Associate Professor of rheumatology,Mashhad University of Medical Sciences, Department of Internal Medicine, Imam Reza Hospital , Mashhad, Iran
author
text
article
2014
per
Introduction: Systemic lupus erythematosus is a common rheumatologic disease. Systemic Lupus Erythematosus disease activity index (SLEDAI) is a valuable and reliable scoring for lupus activity. Always clinical and paraclinical findings in SLEDAI don’t answer with disease progression ,and also some factors including ESR, CRP, Anti-dsDNA and complements may be increased in non-active disease. Therefore, we decided to assess serum uric acid level as an index of disease activity. Materials and Methods: This cross- sectional study was carried out on lupus patients that referred to the rheumatology clinic of Imam Reza hospital in Mashhad. Serum uric acid level, Anti-dsDNA, ESR, C3 and C4 were measured with standard methods and SLEDAI determined for all patients. Pearson’s correlation coefficient ranking was used to evaluate the relation of serum uric acid level with SLEDAI and Anti-dsDNA. Results: In this study, 82 patients (76 females and 6 males) with an average age of 32.02 ± 9.29years and mean disease duration of 4.49± 4.68 years were studied. Serum uric acid levels correlated directly and significantly with SLEDAI (P=0.001, r=0.35), Anti-dsDNA(P=0.0001, r=0.54), and ESR (P=0.001, r=0.41). Serum uric acid levels had indirect and significant correlation with C3 (P=0.04, r=-0.22), and C4 levels (P=0.02, r=-0.25). Conclusion: Our study demonstrated that high serum uric acid levels were correlated with lupus disease activity. Nevertheless, application of serum uric acid level, as an index of lupus disease activity, needed more studies. Acknowledgement: This research financial supported by Research Council of Mashhad University of Medical Sciences and this manuscript is the results of thesis by Dr. Davoodabadi with approval number 901138
medical journal of mashhad university of medical sciences
دانشگاه علوم پزشکی مشهد
1735-4013
57
v.
7
no.
2014
835
840
https://mjms.mums.ac.ir/article_3597_b053ce23de5f8d87a8869c056869a62a.pdf
dx.doi.org/10.22038/mjms.2014.3597
Relationship between social support and mental health in older adults
Seyed Hamid
Nabavi
MS.c in Social Welfare. Addiction & Behavioral Sciences Research Center, North Khorasan University of Medical Sciences & Health Services, Bojnourd, Iran
author
Fardin
Alipour
Ph.D Candidate in Social Work. Department of Social Work, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
author
Ali
Hejazi
Assistant Professor in Health Management. Department of Health, North Khorasan University of Medical Sciences & Health Services, Bojnourd, Iran
author
elham
Rabani
BS.c Student in Public Health. Department of Health. North Khorasan University of Medical Sciences & Health Services, Bojnourd, Iran
author
Vahid
Rashedi
Ph.D Student in Gerontology. Iranian Research Center on Aging, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
author
text
article
2014
per
Introduction: Due to the elderly growing population, different types of social support are very important in promoting their mental health. The main aim of this study was to investigate the relationship between social support and mental health in the elderly. Material & Methods: In this descriptive-analytical study, 200 elderly of Bojnourd city were selected through simple random sampling. To gather the data, General Health Questionnaire (GHQ) and Norbeck Social Support Questionnaire (NSSQ) were used as well as a questionnaire containing demographic variables. Data analysis was completed through SPSS-16. Results:A total of 200 elderly participated in the study. The sample consisted of 90 females (44.6 %) and the mean age of the elderly was 68.91 ± 7.89 years. According to the results, mean of GHQ score in the sample was 24.09 ± 13.08, which indicateed a fairly good level of mental health. In addition, social function had a significant correlation with total social support and subscales of functional, emotional and material. Conclusion: Findings disclosed that increasing the social support of the elderly can put a significant impact on their mental health and social functioning. So, it is essential for the countries to consider the olderlys’ social network and necessities in their large scale plannings. Acknowledgment: : This work was supported by a grant from the North Khorasan University of Medical Sciences & Health Services, Deputy of Research.The authors state no conflict of interest in the current study
medical journal of mashhad university of medical sciences
دانشگاه علوم پزشکی مشهد
1735-4013
57
v.
7
no.
2014
841
846
https://mjms.mums.ac.ir/article_3756_834887edd7cafe9debd9ec0546ab859d.pdf
dx.doi.org/10.22038/mjms.2014.3756
The rate of hypertension and other predisposing systemic factors in spontaneous subconjunctival hemorrhages
Mohammad
Etezad Razavi
Associated Professor of Ophthalmology, Eye Research Center of Mashhad University of Medical Sciences, Mashhad, Iran
author
Mohammad
Sharifi
Assistant Professor of ophthalmology, Eye Research Center of Mashhad University of Medical Sciences, Mashhad, Iran
author
Tahereh
Hajmohammadian
General Practioner
author
text
article
2014
per
Introduction:SPONTANEOUS subconjuctival hemorrhage is a self-limited disorder which was resorbed spontaneously without sequela.Most of them attributed to minor trauma or underlying systemic disease. This study was performed to evaluate the rate of systemic hypertension and other predisposing systemic factors in patients with spontaneous subconjuntival hemorrhages. Materials and Methods : This cross sectional study was performed on patients with spontaneous subconjunctival hemorrhages which referred to one teaching eye hospital. Complete ophthalmic exams were performed and history of hypertension, diabetes mellitus, valsalva maneuver, coagulation disorders, use of anticoagulant drugs, were taken. Systemic blood pressure measured in emergency ward and recorded. Results:Overall 61 subjects were examined. 45 (74%) were male and 16(26%) were female. Their ages ranged from 5 to 71 years (mean =43.5 years). 41 of them (67%) had at least one of the considered associated factors. The history of hypertension was in 10% of cases, 15% of patients had high systolic or diastolic blood pressure measurement without history of hypertension (systolic greater than 135 or diastolic greater than 85 mmHg). 17% of patients had history of diabetes mellitus. History of valsalva maneuver and use of anticoagulant drugs were positive in 15% and10% of them respectively. Conclusion: spontaneous subconjunctival hemorrhage might be due to underlying systemic disease.Amoung predisposing systemic factors, Systemic hypertension, diabetes mellitus and valsalva maneuver are more common causatives. AKNOWLEGEMENT: The authors had not financial interest. Authors acknowledge everyone who had role for collection of data and writing of this article.
medical journal of mashhad university of medical sciences
دانشگاه علوم پزشکی مشهد
1735-4013
57
v.
7
no.
2014
847
851
https://mjms.mums.ac.ir/article_3583_f1d0b57461cfc4752199ee97fbe785e1.pdf
dx.doi.org/10.22038/mjms.2014.3583
Effect of 8 Weeks Aerobic Training on Plasma Apolipoprotein M Levels in Normal and overweight Women
Mitra
Baratzadeh
Master of Exercise Physiology, School of Physical Education and Sport Sciences, University of Mazandaran, Mazandaran, Iran
author
Rozita
Fathi
Associate Professor of Exercise Physiology, School of Physical Education and Sport Sciences, University of Mazandaran, Mazandaran, Iran
author
Elahe
Talebi
Associate Professor of Exercise Physiology, School of Physical Education and Sport Sciences, University of Mazandaran, Mazandaran, Iran
author
Aireza
Safarzadeh
Assistant Professor of Exercise Physiology, School of Physical Education and Sport Sciences, University of Mazandaran, Mazandaran, Iran
author
text
article
2014
per
Introduction: Apolipoprotein M is a new protein located in HDL and has the ability to connect to the cholesterol. There is limited information available regarding the effect of exercise training on circulating levels of apoM. The purpose of this study was to investigate the effect of aerobic exercise on serum apolipoprotein M in normal weight and overweight women. Material and methods:A totallof twenty nine healthy women (31.86 ± 7.04 years) divided in to the two groups based on body mass index: Normalweight (BMI ≤24.9, n =15) and overweight women (BMI ≥25, n =14).The aerobic training program was carried out for 8 weeks, 3 sessions per week at 40-80% of maximal reserved heart rate. Duration of each session was 25 minutes in the first week and it increased up to 45 minutes in the 8th week of exercise. At the beginning and the end of training period, plasma level of apolipoprotein M, HDL, LDL, TG and TC were measured. Results:Fainally 8 weeks of aerobic exercise in normal-weight and overweight women significantly increased the plasma levels of apolipoprotein M, LDL and total cholesterol. while the HDL and TG in both groups showed little change. In addition, after 8 weeks of exercise, there was negatively significant correlation between plasma apolipoprotein M level with, BMI and waisttine to hip ratio in all Subjects. Conclusion: The results of this study suggested that plasma level of apolipoprotein M increase after aerobic exercise training. However, diet control is necessary to determination the exact effect exercise, training on plasma apolipoprotein M levels alterations. Acknowledgment: This study was supported by University of Mazandaran. There was not any conflict of interest in doing this research.
medical journal of mashhad university of medical sciences
دانشگاه علوم پزشکی مشهد
1735-4013
57
v.
7
no.
2014
852
858
https://mjms.mums.ac.ir/article_3612_ae362ef4bce0ca90316510c036eb7dd9.pdf
dx.doi.org/10.22038/mjms.2014.3612
The effect of L-carnitin supplementation on hyperlipidemia in pediatric nephrotic syndrome
Mohammad
Esmaeili
Associate Professor of Pediatric Nephrology, Mashhad University of Medical Sciences
author
Marjan
Esmaeili
Resident of Pediatric, Iran University of Medical Sciences
author
Fatemeh
Ghane
Assistant Professor of Pediatric Nephrology, Mashhad University of Medical Sciences
author
Anoush
Azarfar
Assistant Professor of Pediatric Nephrology, Mashhad University of Medical Sciences
author
text
article
2014
per
Introduction: Hyperlipidemia is a major risk factor for atherosclerosis and cardiovascular incidents. Abnormalities in lipoproteins and lipids profile are common in patients with pediatric idiopathic nephrotic syndrome and may contribute to atherosclerosis. Prescription of lipid lowering agents such as statins because of myopathy and growth disorders, are not recommended in child-aged groups. However, there isn’t any investigation on carnitine effects on lipids profile of patients with childhood nephrotic syndrome which is the propose of our study. Materials and Methods: In this case-control study, case group included 16 patients in 2-12 years of age with steroid resistant nephrotic syndrome, receiving prednisolon, cyclosporine and carnitine (25mg/kg/day) within a 3 months period and control group included 17 age and sex matched patients, receiving standard treatment (prednisolon, cyclosporine), were compared. In both groups, biochemical parameters like triglyceride, cholesterol, VLDL, LDL, HDL, BUN, creatinine and serum albumin were measured. Results: At the end of the study period, L-carnitine treated group showed no significant difference in the biochemical markers compared with the control group (P-values>0.05). Conclusion: Our study indicates that oral administrations of L-carnitine with the dose of 25 mg/kg/day did not have any effects on lipoprotein profile of persistent childhood nephrotic syndrome. Acknowledgement: This study was supported by a grant from the Vice chancellor for research of the Mashhad University of Medical Sciences for the research project as a medical student thesis with approval number of 87718. We would like to thank Dr. Naser Shoeibi for statistical analysis and Ms. Saeide seyed hoseini for typing of the manuscript.
medical journal of mashhad university of medical sciences
دانشگاه علوم پزشکی مشهد
1735-4013
57
v.
7
no.
2014
859
865
https://mjms.mums.ac.ir/article_3616_67c60a97f8df5ddc74157878cf7e28a4.pdf
dx.doi.org/10.22038/mjms.2014.3616
Treatment of hyperglycemia in patients with diabetes
eyedSeifollah
BeladiMousavi
Associate Professor, Chronic Renal Failure Research Center, Department of Internal Medicine, Faculty of Medicine, Jundishapur University of Medical Sciences, Ahvaz, Iran
author
Parvin
Layegh
استادیار غدد، مرکز تحقیقات غدد درون ریز، دانشکده پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران
author
Abbasali
Zeraati
دانشیار نفرولوژی، مرکز تحقیقات عوارض پیوند کلیه، دانشگاه علوم پزشکی مشهد، مشهد، ایران
author
Mohammad reza
Tamadon
-فوق تخصص نفرولوژی، دانشگاه علوم پزشکی سمنان، سمنان، ایران
author
text
article
2014
per
Nephropathy occurs in 20-40% of diabetic patients and diabetes mellitus is the most common cause of ESRD .the aim of this study was review the metabolism of glucose and treatment of diabetes in patients with this disease. Chronic renal failure is typically associated with insulin resistance, decrease of insulin secretion and, in advanced renal failure, decreased insulin degradation. Decrease of insulin degradation can lead to a marked decrease in insulin requirement or even the cessation of insulin therapy in type 2 diabetes and the development of spontaneous and severe hypoglycemia. Although, several large studies have found no significant correlation between glycemic control and survival of patients with ESRD, however, for prevention of diabetes-related damage to other organs, good glycemic control should be considered as a significant treatment goal.The goal of glycemic control in diabetic patients on chronic dialysis is the fasting blood glucose below 140 mg/dL, one-hour postprandial value of less than 200 mg/dL and the glycated hemoglobin level between 6 to 7 in type 1 diabetics, and between 7 to 8 in type 2 diabetics. Glipizide is metabolized by the liver and therefore is the oral hypoglycemic drug of choice in many patients with chronic renal failure.Repaglinide is also principally metabolized by the liver but hypoglycemia is common among patients with severe renal impairment and Initiation of treatment should therefore be with 0.5 mg daily and close careful monitoring of blood glucose levels is essential. Metformin should be avoided in patients with ESRD due to increased risk of rare but potentially fatal lactic acidosis. .
medical journal of mashhad university of medical sciences
دانشگاه علوم پزشکی مشهد
1735-4013
57
v.
7
no.
2014
866
873
https://mjms.mums.ac.ir/article_3591_4d0e9066d3fb55cb502918e9882c88f2.pdf
dx.doi.org/10.22038/mjms.2014.3591
Treatment of fibrous dysplasia with Bisphosphonates
Rahim
Vakili
Professor of Pediatric Endocrinology Department Emam Reza Hospital ,Mashhad University of Medical Sciences, Mashhad, Iran
author
Mohammad
Gharahdaghi
Assistant Professor of Pediatric Department Emam Reza Hospital ,Mashhad University of Medical Sciences, Mashhad, Iran
author
Samaneh
Kouzegaran
Assistant Professor of Pediatric Department Emam Reza Hospital ,Mashhad University of Medical Sciences, Mashhad, Iran
author
text
article
2014
per
Introduction: Fibrous dysplasia is a benign skeletal lesion. It is related to McCune-Albright syndrome with patchy cutaneous pigmentation. Recent trials in pediatric patients with fibrous dysplasia have shown encouraging results. Bisphosphonate therapy may help to improve function, decrease pain, and lower fracture risk in appropriate selected patients. Index patient, a 12-year-old girl with history of limping and bone pain for 2 years that had no response to common treatment. After more evaluation, she referred to pediatric endocrinology department with the diagnosis of fibrous dysplasia and was treated using periodic intravenous pamidronate every three month. She showed good outcome and symptomatic improvement over 6 month duration of fallow up. Conclusion: Recent trials in pediatric patients with fibrous dysplasia have shown encouraging results. In our patient treatment with periodic intravenous infusion of pamidronate resulted in an improvement of pain and limping without important side effects. Acknowledgement: We would like to thank Radiology and laboratory department of Imam Reza hospital. Conflict of Interest: None
medical journal of mashhad university of medical sciences
دانشگاه علوم پزشکی مشهد
1735-4013
57
v.
7
no.
2014
874
878
https://mjms.mums.ac.ir/article_3599_2933acb78b13d6349e7f6e72e8a23443.pdf
dx.doi.org/10.22038/mjms.2014.3599