Effect of CO-Q10 Supplementation on CPR and Homocysteine Level in Chronic Hemodialysis Patients of Loghman Hakim and Ashrafi Esfahani Dialysis Center
Narges
Zahed
assistant professor of Nephrology, Shahid Beheshti University of Medical Science, Tehran, Iran
author
Maryam
Ghassami
: corresponding author, resident of internal medicine, Shahid Beheshti University of Medical Science, department of Nephrology, Loghman Hakim Hospital, Tehran, Iran
author
Marjan
Sharifi
resident of internal medicine, Shahid Beheshti University of Medical Science, Tehran, Iran.
author
Mehdi
Yaseri
assistant professor of Biostatistics , Tehran University of Medical Science, Tehran, Iran.
author
text
article
2015
per
Introduction:The most common causes of death in ESRD patients is cardiovascular disease and inflammatory markers related to coronary events. Q10 is a protective supplement from free radicals oxidative damage. In addition, hyperhomocysteinemia is an independent CAD risk factor. Because of increasing oxidative stress in dialysis patients, and the effect of CO-Q10 in decreasing oxidative stress, in this study we evaluated the effect of CO-Q10 on CRP level as an inflammatory marker and homocysteine in dialysis patients.Methods:This was a single-blind, randomized placebo control, cross-over, clinical trials. Which all patients received placebo and C0-Q10 100mg/d during the three months in each phases, with 2 weeks washout period. Plasma level of CRP and homocysteine from the beginning of the study and at the end of each period, were measured. Results: A total of 34 patients randomized, but 26 patients completed the study protocol. The treatment effect of CO-Q10 on CRP level is significant (p value˂0.001)(95%CI= -20.1 to -10.5) and it was also significant for the increasing albumin level. (Pvalue=0.044) (95% CI =0.0-0.6), However, there was not any significant effect on homocysteine level (pvalue=0.630).Conclusion:CO-Q10 could significantly decrease CRP level as an inflammatory marker and can protect cardiovascular events.
medical journal of mashhad university of medical sciences
1735-4013
58
v.
4
no.
2015
167
174
https://mjms.mums.ac.ir/article_4629_c2dcb567041531e48437a469c80b1353.pdf
dx.doi.org/10.22038/mjms.2015.4629
Comparison of Nalidixic acid and Trimethoprim – sulfamethoxazole in prophylaxis of recurrent urinary tract infection in children
Fatemeh
Ghane Sharbaf
Assistant Professor of Pediatric Nephrology, Mashhad University of Medical Sciences, Mashhad, Iran
author
Mohammad
Esmaeili
Associate Professor of Pediatric Nephrology, Mashhad University of Medical Sciences, Mashhad, Iran
author
Mehran
Beiraghi toosi
Assistant Professor of Pediatric Neurology, Mashhad University of Medical Sciences, Mashhad, Iran
author
Marjan
Esmaeili
Resident of Pediatric, Iran University of Medical Sciences, Tehran, Iran
author
text
article
2015
per
Introduction: Urinary tract infection (UTI) is one of the most common lifelong bacterial diseases.UTI can lead to serious complications such as renal scar, hypertension, and chronic renal failure. Prolonged prophylactic antibiotic is required in cases that are prone to occurrence and progression of renal scarring. Purpose of study is Comparison of Nalidixic acid and Trimethoprim-sulfamethoxazole in prophylaxis of recurring urinary tract infection in children. Methods: 102 children, 1 to 15 years old, with urinary tract infection that needed prophylactic antibiotic for prophylaxis of UTI were enrolled in the study. Following treatment of the acute infection, children were randomly treated with prophylactic antibiotic therapy of nocturnal co-trimoxazol or nalidixic acid for 6 months. Results: Of all 102 patients, 50 cases received nalidixic acid and 52 cases received co-trimoxazol. These two groups had no significant difference regarding age and gender. During 6 months of follow-up, the recurrence was in 48% of the children undergoing prophylaxis therapy with nalidixic acid. This was significantly more than the group that received co-trimoxazol (21.1%; p=0.006). Conclusion: Recurring urinary tract infection in the two groups was independent of age, sex and anatomical anomalies in kidneys. As prophylaxis with co-trimoxazol is more effective than nalidixic acid, it is recommended for prophylaxis of urinary infection.
medical journal of mashhad university of medical sciences
1735-4013
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v.
4
no.
2015
175
184
https://mjms.mums.ac.ir/article_4570_97bd956c62a49e12692c6add430dec89.pdf
dx.doi.org/10.22038/mjms.2015.4570
Effects of Various Stages of NonAlcoholic Fatty Liver Disease Associated with Elevated Liver Enzyme (AST/ALT) Upon Hemodynamic Portal Vein
Hamidreza
Norouzi
Radiologist Assistant professor, Mashhad University of Medical Sciences, Mashhad, Iran
author
Hosein
Movahedian
Radiologist Assistant, Mashhad University of Medical Sciences, Mashhad
author
text
article
2015
per
Background:The purpose of this study is to investigate the association of nonalcoholic fatty liver disease and portal vein doppler indices. This assay may be useful in evaluating the natural course of NAFLD and monitor treatment efficacy on follow-up. Material and Methods:This case control study was performed in 54 patients with NAFLD and 54 normal healthy adults who served as the control group. The patients presented with elevated liver enzymes levels (ALT/AST) and hyper echogenic livers in the B-mode ultrasonography examination. After an 8-hour fast, duplex doppler ultrasonography were performed, and portal vein pulsatility index (VPI), and mean portal velocity (MPV) and portal diameter (PD) were measured. Results:VPI and MPV and PD values were 0.3931±0.09, 10.44± 1.65 cm/second and 9.5±1.65 respectively, in patients with NAFLD and 0.68±0.06, 17.09±1.72 cm/second and 9.3±1.6 in the control group and these parameters were significantly lower in the NAFLD group (P< 0.01). We found no significant difference between the two case and control groups, considering PD (P = 0.05). Conclusion: In our study, VPI and MPV were significantly lower in patients with NAFLD than in the control group, which could have been caused by impaired vascular compliance due to fat deposition in hepatocytes. it is important to find less invasive techniques such as described in this study to detect NAFLD.
medical journal of mashhad university of medical sciences
1735-4013
58
v.
4
no.
2015
185
190
https://mjms.mums.ac.ir/article_4576_3fa93a6a99a329a2dcfec39bc0dbb553.pdf
dx.doi.org/10.22038/mjms.2015.4576
Relationship between anemia and Peak oxygen uptake in hemodialysis patients
Boshra
Hasanzamani
استادیار گروه نفرولوژی،دانشگاه علوم پزشکی مشهد، مشهد، ایران
author
Mohammad
Mojahedi
-استاد گروه داخلی،دانشگاه علوم پزشکی مشهد، مشهد، ایران
author
Abbas ali
Zeraati
-دانشیار گروه نفرولوژی،دانشگاه علوم پزشکی مشهد، مشهد، ایران
author
saba
Khajehdargi
پزشک متخصص، مشهد، ایران
author
Amir
Asnaashari
استادیار بیماری های ریه، دانشگاه علوم پزشکی مشهد، مشهد، ایران
author
text
article
2015
per
Introduction:The measurement of exercise capacity through Peak Oxygen Uptake is an important factor in predicting mortality and survival in patients after transplantation. Methods:In this study 31 renal transplant candidates aged 17 to 58 years were evaluated through spirometery and Exercise test and results were registered according to the assumed inclusion criteria including age , hemoglobin (Hb) and hematocrite and the results were analyzed through statistical and analytical measures.Among these 31 patients there were 5 women and 26 men, that the averages of hemoglobin were 12±1 (maximum 13.5 and minimum 10.6) and 11.8 ±2 (maximum 15.6 and minimum 7.4) respectively. According to the degree of anemia ، patients were divided into three categories. Mild anemia ( Hb between 6 to 9 )، moderate anemia ( Hb between 9 to 12 ) and normal ( Hb 12 and more ).Results:After dividing of VO2 max in to 2 groups including normal (≥20) and abnormal (20˃) and analysis via independents T test , we found that there was a correlation between hemoglobin and hematocrite and VO2 max, and the P values were 0.015 and 0.005 respectively. Conclusion:we can help patients with an effort to correct anemia leading to more survival and less mortality in those with end stage renal disease expecting renal transplantation.
medical journal of mashhad university of medical sciences
1735-4013
58
v.
4
no.
2015
191
196
https://mjms.mums.ac.ir/article_4628_ee464b897051187229deee5d25e44baa.pdf
dx.doi.org/10.22038/mjms.2015.4628
The cytotoxic effect of mirtazapine on mitotic index, nucleus divition index and proliferation index in human peripheral blood lymphocyte
Mostafa
Norizadeh Tazehkand
pHD of Biotechnology, Dept. of Biotechnology, Cukurova University, Adana, Turkey
author
Mehmet
Topaktas
Prof of Biotechnology, Dept. of Biotechnology, Cukurova University, Adana, Turkey
author
Ebrahim
Valipour
pHD of Biotechnology, Dept. of Biotechnology, Cukurova University, Adana, Turkey
author
Orkideh
Hajipour
pHD student of Molecular Biology, Dept. of Molecular Biology, Pamukkale University, Denizli, Turkey
author
text
article
2015
per
Introduction: Mirtazapine (Remeron) is widely used as an antidepressant drug to treatment of major depressive disorders in all over the world. Mirtazapine plays its role by increasing norepinephrine and serotonin levels in brain. To days, the heavy and strongly use of the antidepressant necessitates more studies and being sure about the drug. Hence, the present research is aimed to study of cytotoxic effect of Mirtazapine on human peripheral blood lymphocytes by numeration of Mitotic Index (MI), Nuclear Division Index (NDI) and Proliferation Index (PI) tests. Materials and Methods: In this research, cytotoxic effect of mirtazapine at 24 and 48 hours treatment on four concentration (10, 25, 40, and 55µg/ml) was studied on human peripheral blood lymphocytes (from two male and two female) and the t-test was used for the statistical analysis. Results: Exposing to the mirtazapine for 24 and 48 hours treatment periods leaded to a decrease in mitotic index and nucleus division index. Also, mirtazapine cause decreased proliferation index of the both 24 and 48 hours and the decreasing effect of mirtazapine on cell proliferation at 24h and 48h treatment was concentration dependent manner. Conclusion: According to this study mirtazapine has cytotoxic effects on human's cells, so mirtazapine can be valuable candidate for cancer treatment
medical journal of mashhad university of medical sciences
1735-4013
58
v.
4
no.
2015
197
203
https://mjms.mums.ac.ir/article_4551_f25514b110a74d8dd9e5941c96cb1325.pdf
dx.doi.org/10.22038/mjms.2015.4551
Molecular Detection of Pneumocystis jirovecii in diabetic Patients with respiratory disorder at Emam Reza Hospitals , Mashhad.
Abdolmajid
Fata
1. Professor & Head of Dept. Parasitology & Mycology , Cutaneous Leishmaniasis Research Center, School of Medicine, Mashhad University of Medical Sciences.
author
Mahmoud
Parian Noghani
Dept. Parasitology & Mycology, School of Medicine, Mashhad University of Medical Sciences
author
Fariba
Rezaeitalab
Associate Professor , Dept. internal Medicine, Emam Reza Hospital, Mashhad University of Medical Sciences .
author
Mohammad Javad
Najafzadeh
Dept. Parasitology & Mycology, School of Medicine, Mashhad University of Medical Sciences
author
Ali
Naser
Dept. Parasitology & Mycology, School of Medicine, Mashhad University of Medical Sciences.
author
Lida
Jarrahi
Assistant Professor , Dept. community medicine, School of Medicine, Mashhad University of Medical Sciences
author
Behzad
Mavaji
2. Dept. Parasitology & Mycology, School of Medicine, Mashhad University of Medical Sciences.
author
text
article
2015
per
Introduction: Pneumocystosis is fungal pulmonary disease due to Pneumocystis jirovecii (JP).The infection is mostly seen in immunosupressed patients and those individuals with decreased immunity. The aim of this study was to identify JP infection among the diabetic patients hospitalized due to any chronic pulmonary disorder and had indication of Broncho-alveolar Lavage (BAL). Method: BAL samples of all 16 diabetic patients with pulmonary disorder were obtained by pulmonary disease specialist and transferred under proper conditions to Mycology Lab. The samples centrifuged and kept in the refrigerator in order to do DNA extraction and Nested- PCR examination. Results: of the total 16 samples obtained from hospitalized diabetic 3 samples (18.8%) were positive for PJ PCR test. Of 3 patients, 2 were males and 1 was female . Conclusion: High blood sugar can lead to dysfunction of the immune system which also reduces the power of the immune system, Therefore, diabetic patients with pulmonary disorder should be considered as a source of PJ and candidate for pneumocystosis.
medical journal of mashhad university of medical sciences
1735-4013
58
v.
4
no.
2015
204
210
https://mjms.mums.ac.ir/article_4627_a002ad03ffb7e4a2f37e70afaaed0b0f.pdf
dx.doi.org/10.22038/mjms.2015.4627
Comparison the diagnostic value of SLR and Slump tests in clinical evaluation of patients with lumbar disc herniation
Elham
Ghazi
General Physician
author
Saeed
Rahighi
Assistant Professor, Department of Neurosurgery, Faculty of Medicine, Islamic Azad University , Mashhad Branch, Mashhad, Iran
author
text
article
2015
per
Introduction One of the common causes of low back pain is the disc herniation. There are different diagnostic tests including Slump and SLR tests which have been used to identify the nerve root compression. For physical examination in the Slump test, patient is examined in the sitting position with thoracolumbar and cervical flexion along with knee extension and dorsiflexion of the foot. In the SLR test, the examiner flexes the patients' hip while maintaining the knee in extension (in the supine position). MRI2 is the gold standard diagnostic procedure for lumbar disc herniation. The purpose of this study was to compare the sensitivity of Slump and SLR tests in detecting the lumbar disc herniation. Methods In this study on the 60 patients aged 18 to 60 years ,that were hospitalized due to lumbar disc herniation at Aria, Farabi and 22 Bahman hospitals, the Slump and SLR tests were performed. The results of these tests were examined regarding their agreement with the patients MRI. Data were analyzed by using SPSS v.20. The sensitivity for each test was computed and compared with each other. Results The sensitivity of Slump and SLR tests were 83.3% and 61.7% respectively with statistically significant difference(p<0.05). Regarding our results, the Slump was found to be most sensitive in the study group and also in its subgroups. When the subgroups were considered, the Slump test was found most sensitive, comparing to SLR, in the all levels and also in all locations . Conclusion Overall, the results of this study show that the Slump test, by being more sensitive, may be a valuable tool for suggesting a diagnosis.
medical journal of mashhad university of medical sciences
1735-4013
58
v.
4
no.
2015
211
216
https://mjms.mums.ac.ir/article_4572_854d24a0f9f8752a52634d4aade5d58d.pdf
dx.doi.org/10.22038/mjms.2015.4572
Assessment of nutritional intake in intensive care unit patients of Ghaem hospital
Forough
Shayesteh
MSc candidate in nutrition, Department of Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran
author
Somayeh
Poudineh
MSc candidate in nutrition, Department of Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran
author
3Mahsa
Mohammad-Zadeh
1MSc candidate in nutrition, Department of Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran
author
Mahdieh
Pouryazdanpanah-Kermani
PhD Student in Nutrition sciences, Department of Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran
author
Samaneh
Sadat Ayoudi
4PhD Student in Nutrition sciences, Department of Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran
author
Abdolreza
Norouzy
Assistant Professor in Nutrition, Department of Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran
author
text
article
2015
per
Introduction: disease related malnutrition lead to increased infections, delayed healing, prolonged hospital stay, increased hospital costs and death. One of the several factors implicated in the etiology of malnutrition is sub-optimal food intake during hospitalization. The aim of present study was to investigate the nutritional intake of intensive care unit patients. Materials and Methods: This cross sectional study was conducted over a period of one day. Questionnaire containing demographic information, anthropometric measurements, and nutrition type and nutrition line for patients was completed. Ideal body weight was calculated by patient's height that was estimated based on the ulna length. Energy and protein requirements were calculated by using the equation 25-30 kcal / kg and 1-1.5 g / kg, respectively, for ideal body weight. Statistical analysis was performed using SPSS 16 and t-test (P≤0.05). Descriptive statistics was carried out for qualitative and quantitative variables. Results: 46 subjects aged 18-89 (59±20.5) years participated in this study. Mean of hospital stay was 20.2 ± 27.2. Energy and protein intake of enteral patient was significantly (P≤0.05) differ with energy and protein requirements. Only 50% of oral intake patient ate all of their lunch meal. Conclusion: Gavage solution prepared in the hospital was insufficient to meet the energy requirements of patients but provide more than the need of protein requirements. 50% of oral intake patients were ate less than half of their meals provided.
medical journal of mashhad university of medical sciences
1735-4013
58
v.
4
no.
2015
217
224
https://mjms.mums.ac.ir/article_4571_10159dc9c7c5d0a738cbc1ff2f9e5c3a.pdf
dx.doi.org/10.22038/mjms.2015.4571
Autoimmune Hepatitis Induced by Interferon Beta Therapy in a Patient with Multiple Sclerosis
Ali
Beheshti
دانشیار گروه گوارش و کبد، دانشگاه علوم پزشکی مشهد، مشهد، ایران
author
Batool
Birjandi
دستیار تخصصی داخلی ، دانشگاه علوم پزشکی مشهد، مشهد، ایران
author
Ahmad
Khosravi
استاد گروه گوارش و کبد، دانشگاه علوم پزشکی مشهد، مشهد، ایران
author
Kamran
Ghafarzadegan
پاتولوژیست، دانشگاه علوم پزشکی مشهد، مشهد، ایران
author
text
article
2015
per
Introduction Interferon beta is one of the most common treatments to prevent relapses in multiple sclerosis. is hepatic injury is one of the major complications of Interferon beta but rarely can result in Autoimmune Hepatitis. Case report This is a case report of a 18 years old lady , who received interferon beta for treatment of multiple sclerosis and presented by jaundice and maculopapular itchy skin lesion that was hospitalized in gastroenterology department. Liver biochemistry tests revealed acute hepatitis (alanine and aspartate aminotransferase elevation and hyperbilirubinemia).Other causes of acute hepatptis were excluded. Biopsy of Liver consistent with Autoimmune Hepatitis. Beta interferon was discontinued and oral steroid was started that led to complete resolution. Conclusion This report has shown that particular attention must be paid side effects of beta interferon is necessary in the clinical practice.
medical journal of mashhad university of medical sciences
1735-4013
58
v.
4
no.
2015
225
229
https://mjms.mums.ac.ir/article_4630_da51e943a22198bcbd0b3c95a748033a.pdf
dx.doi.org/10.22038/mjms.2015.4630