ORIGINAL_ARTICLE
Evaluation of Thyroid Function and Autoimmune Activity and Correlation of them with Thyroid Sonographic Findings in Patients with Vitiligo
Introduction Vitiligo may be associated with autoimmune thyroid diseases. Early sonographic findings in thyroid may be detectable even before occurence of clinical manifestations. So, we evaluated role of thyroid sonography in vitiligo patients without previously known thyroid disorders. Materials and Methods This case-control study was performed in Ghaem Hospital in Mashhad between 2008 to 2010 years. A total of fifty patients with vitiligo and 35 healthy controls were enrolled. In all participants, dermatologic examination, thyroid autoimmunity and function tests and sonography, were performed. Chi-square, independent t-test, mannwhitney U and Spearman Rho tests, used for statistical analysis. P values less than 0.05 considered significant. Results TSH level (p<0.001) and Anti-TPO (p=0.002) were significantly more in vitiligo patients than controls, but no significant difference was seen in Anti-Tg antibodies (p=0.118) between two groups. No correlation was seen between Anti-TPO level and thyroid volume (p=0.30). Thyroid heterogenicity in sonography was more common in vitiligo patients (p=0.004). There was significant positive correlation between Anti-TPO and TSH levels ( pConclusion Autoimmune thyroiditis was the most common finding in vitiligo patients. Sonography could be used as an adjuvant for confirmation of asymptomatic autoimmune thyroiditis in patients with vitiligo.
https://mjms.mums.ac.ir/article_1223_02c8ca297b5c4936056ec3e4eb2af3a9.pdf
2013-07-23
133
138
10.22038/mjms.2013.1223
Autoimmunity
Sonography
Thyroid
Vitiligo
Parvin
Layegh
layeghpa@mums.ac.ir
1
Assistant Professor of Endocrinology , Endocrine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Pouran
Layegh
2
Associate Professor of Dermatology, Cutaneous Leishmaniasis Research center
, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Masoud
Pezeshki Rad
pezeshkiradm@mums.ac.ir
3
Assistant professor of Radiology, Vascular & Endovascular Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Parvaneh
Layegh
layeghpr@mums.ac.ir
4
Assistant professor of Radiology, Mashhad University of Medical Sciences, Mashhad, Iran
LEAD_AUTHOR
ORIGINAL_ARTICLE
The Effect of Diet and Physical Activity on Obese Women with Polycystic Ovary Syndrome
Introduction Systemic sclerosis (SSc) is a connective tissue disease with unknown etiology which causes remarkable morbidity and mortality. Raynaud's phenomenon (RP) is a complication of SSc leading to ischemia of extremities and digital gangrenes. Treatment of RP is a clinical problem and often remains inefficient. Ginkgo biloba is derived from the leaf of the Maidenhair tree. Its’ extract is leaded to improve tissue circulation; this study was designed to evaluate the efficacy of ginkgo biloba in the treatment of RP in systemic sclerosis. Materials and Methods A total of Seventeen patients with SSc and RP were received either Ginkgo biloba pills (40 mg three times per day) or placebo for 3 months in a randomized, double blind, controlled trial. A two-week assessment period before treatment was done during which patients were asked to record the frequency, duration, and severity [using 10-point Raynaud’s Condition Score (RCS)] of attacks in a diary form before intervention. They continued to record the same data in their diary forms after intervention and were visited at the end of each month. Results The mean duration of attacks and the RCS were significantly decreased in Ginkgo group compared with the baseline (P<0.05), whilst no significant reduction was observed in the mean number of attacks (P=0.147). In the placebo group no significant reduction was shown in the mean duration or number of attacks, and RCS. Conclusion Ginkgo biloba reduces the duration and severity of Raynaud's attacks of patients with systemic sclerosis.
https://mjms.mums.ac.ir/article_1224_37c3c265f1c82035f23962bf17886a4c.pdf
2013-07-23
139
144
10.22038/mjms.2013.1224
Ginkgo biloba
Raynaud's phenomenon
Scleroderma
Systemic sclerosis
Mohammad Hassan
Jokar
1
Associate Professor of Rheumatology, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Seyedeh Zahra
Mirfeizi
mirfeiziz@mums.ac.ir
2
Assistant Professor of Rheumatology, Mashhad University of Medical Sciences, Mashhad, Iran
LEAD_AUTHOR
Mani
Mirfeizi
mani@kiau.ac.ir
3
Assistant Professor of Midwifery, Karaj Branch, Islamic Azad University, Karaj, Iran
AUTHOR
ORIGINAL_ARTICLE
Comparative Study between Intraocular Pressure and Refractive Error Among Attendant of Valiaser Clinic Hospital 2011-2012
Introduction
Refractive errors are common eye problems which is a risk factor for impaired vision and glaucoma. The expert supposed that one possible reason for the increased incidence of glaucoma in patients with refractive errors is intraocular pressure. This study was conducted to determine the relationship between refractive errors and intraocular pressure.
Materials and Methods
In this case - control study 115 patients with refractive error as the case group and 115 clients who were matched for age, sex and other characteristics, and did not have refractive error were selected through the sampling as the control group.The non-contact tonometer method, without the use of anesthetic in eye and with the help of air pressure was used the measure and record the intraocular pressure by an opopetrist specialist. Data were collected in spss15 software and analyzed by using Chi Square, t test and one way Variance at the level of 0.05.
Results
The results showed that mean IOP of right eye in the case group was higher (15.75 ± 2.28) than control group (15.03 ± 2.16) (P = 0.015). The mean intraocular pressure of left eye also in the case group were higher (15.37±2.38) than the control group (14.69±1.99) (P=0.02).
Results showed that in the right eye and the left eye in patients with refractive error the intraocular pressure was higher than those without refractive error.However, the mean IOP showed no significant differences based on the type of refractive error.
Conclusion
The results of this study support the hypothesis that the refractive errors are risk factors of intraocular pressure.
https://mjms.mums.ac.ir/article_1225_028f75770d484a6cb27b96842c19ee0f.pdf
2013-07-23
145
149
10.22038/mjms.2013.1225
Intraocular pressure
Refractive errors
Risk factors
Gholamhossein
Yaghoobi
yaqubig@yahoo.com
1
Associate professor of Ophthalmology Birjand University of Medical science, Birjand, Iran
LEAD_AUTHOR
Behrouz
Heydari
اذ51337@غشاخخ.زخئ
2
Assistant Professor of Ophthalmology, Birjand University of Medical science, Birjand, Iran
AUTHOR
Mohammad Reza
Miri
moh2516@yahoo.com
3
Associate professor of Ophthalmology Birjand University of Medical science, Birjand, Iran
AUTHOR
Mohammad Hossein
Davari
mhd_1337@yahoo.com
4
Assistant Professor of Ophthalmology, Birjand University of Medical science, Birjand, Iran
AUTHOR
Abbas
Hossein Rad
ahrad2@yahoo.com
5
Assistant Professor of Ophthalmology, Birjand University of Medical science, Birjand, Iran
AUTHOR
Hossein
Irankhai
iranh@yahoo.com
6
Medical Student, Birjand University of Medical science, Birjand, Iran
AUTHOR
ORIGINAL_ARTICLE
Compare the Effect of 4 Weeks of Resistance and Aerobic Training on Blood Coagulation and Fibrinolytic Factors in Inactive Older Men
Introduction
Changes and imbalances in the homeostasis system is one of the main causes of heart attacks. Conflicting data existed about the effect of specific exercises on these factors. Therefore, the purpose of this study was to compare the effect of 4 weeks of resistance training and aerobic exercises on blood coagulation and fibrinolytics factors in inactive older men.
Materials and Methods
A total of 30 elderly people (age 63/73 ± 2/66 years) were randomly divided into 3 groups: an aerobic (n=10), resistance (n=10) and control (n =10) groups. Respectively, aerobic and resistance groups, participated in a program of aerobic and resistance exercise (3 days a week for 4 weeks). Body weight, bmi and coagulation factors levels such as, fibrinogen, pt, ptt and platelet count and also d-dimer fibrinolytic factors were measured.
Results
Overall 4 weeks of aerobic exercise training in older individuals significantly reduced fibrinogen, pt, ptt and platelets count levels, whereas increased d-dimer levels.
Also 4 weeks of resistance training significantly reduced fibrinogen, pt, ptt and platelets count levels, but increased d-dimer fibrinolytic factor. It was also found that the effect of resistance training on blood coagulation factors such as pt, ptt, platelet count and d-dimer fibrinolytic factors was more than aerobic training, but the effect of aerobic training on coagulation factor fibrinogen was higher than resistance training.
Conclusion
This study suggested that participation in aerobic and resistance activities can be very useful for prevention of threatening complications of hemostatic system and the aging process.
https://mjms.mums.ac.ir/article_1226_3fdde0999e60a311fde3a8c5bbf59bda.pdf
2013-07-23
150
158
10.22038/mjms.2013.1226
Aerobic workout
Fibrinogen
Platelets
Resistance training
1Hassan
Amouzad Mahdirajei
hassanamouzad@yahoo.com
1
Masters of exercise physiology, Islamic Azad University, Sari branch, Sari, Iran
LEAD_AUTHOR
Mojtaba
Mirsaiedii
2
Masters of exercise physiology, Islamic Azad University, Sari branch, Sari, Iran
AUTHOR
Sajedeh
Fadaei Reihan Abadei
3
- Masters of exercise physiology, Islamic Azad University, Sari branch, Sari, Iran
AUTHOR
ORIGINAL_ARTICLE
The Comparison between Two Ways for Hands Decontamination of Hospital Personnel: with Water and Soap or Alcohol
Introduction
One of the most important ways of infectious transmission is the personnel’s contaminated hands .In orther to compare water and soap with alcohol in eradication of staff hands’ pathogens, this study was carried out on 100 personnesl in Imamreza hospital.
Materials and Methods
In this study we took samples from 100 personnel's palms in different wards of hospital while doing their nursing activites.Washing hands with water and soap or 70٪alcohol was performed by them for 20 seconds with the manager observation, then the sampling was repeated and transfored to bloody agar culture unit.
Results
Washing hands with soap or alcohol decreased the pathogens of the personnel hands. (p<0/001). Alcohol was more effective (76.9%) than water and soap with (23.1%) (p<0/002). The most common pathogens were: Staphylococcus epidermidis, Kllebsiella pneumoniae and E. coli. The most contaminated department was ICU ward (100%).
Conclusion
Hand washing before and after contact with patients is an easy way to control hospital infections and if done with alcohol is more effective than with water and soap in eradicating staff hands’ microorganisms.
https://mjms.mums.ac.ir/article_1227_006144f43c2757558cc69008b2f65cad.pdf
2013-07-23
159
164
10.22038/mjms.2013.1227
Alcohol
Nosocomial pathogens
Staff’s hand
Soap and water
Azadeh
Ebrahim zadeh
1
1- Assistant Professor of Infectious disease, Birjand University of Medical Sciences, Birjand, Iran
AUTHOR
Zahra
Mazloum Khorasani
mazloumz@mums.ac.ir
2
Assistant Professor of Endocrine, Endocrine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
LEAD_AUTHOR
Mahsa
Mousavi
3
Assistant Professorof Internal, Bojnourd University of Medical Sciences, Bojnourd, Iran
AUTHOR
Majid
Zare
4
Assistant Professor of microbiology, Birjand University of Medical Sciences, Birjand, Iran
AUTHOR
ORIGINAL_ARTICLE
Relation between Serum Parathormon Hormone (PTH) and Serum Zinc Levels in Hemodialysis Patients
Introduction Secondary hyperparathyroidism is a common and curable complication in CRF patients. Although secondary hyperparathyroidism and zinc deficiency both are seen in CRF patients as complication but correlation between them is not well defined. In this study we have evaluated the correlation between serum zinc levels and serum PTH in hemodialysis patients. Materials and Methods This cross-sectional study was performed on one group consisting of hemodialysis patients (30 cases), in Mashhad Imam Reza hospital. Patients who were under regular hemodialysis for at least 3 months after starting dialysis, with minimum age of 15, and were stable in the last 2 months entered the study. Levels of zinc, calcium, phosphorus, PTH, albumin and ALP were measured. Serum zinc was measured in fasting status by spectrophotometery. Results Prevalence of zinc deficiency in hemodialysis patients was 65%. In hemodialysis patients no significant correlation was detected between serum zinc and PTH. There was also no significant correlation between serum zinc and calcium, phosphorus, ALP and albumin. However in hemodialysis patients there was a significant correlation between serum albumin and PTH. Conclusion In hemodialysis patients there was no significant correlation between serum zinc levels and serum PTH.
https://mjms.mums.ac.ir/article_1228_f284247854ac7ba238684918f848b1ef.pdf
2013-07-23
165
169
10.22038/mjms.2013.1228
hemodialysis
Parathormon (PTH)
zinc
Abbas Ali
Zeraati
zeraatia@mums.ac.ir
1
Assistant Professor of Nephrology, Kidney Transplantation Complications Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Asadollah
AfshariSaleh
2
Associate Professor of Internal, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Zahra.
Abbasi
3
General physician, Kidney Transplantation Complications Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Mohammad Reza
Parizadeh
parizademr@mums.ac.ir
4
- Associate Professor of Biochemistry, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Farzaneh
Sharifipour
sharifipourf@mums.ac.ir
5
Assistant Professor of Nephrology, Kidney Transplantation Complications Research Center, Mashhad University of Medical Sciences, Mashhad, Ira
AUTHOR
Matin
Bkhtiari
6
Resident of Pediatric, Gorgan University of Medical Sciences, Gorgan, Iran
AUTHOR
Seyed Seifollah
Beladi Mousavi
dr.beladimousavi@ajums.ac.ir
7
Associate Professor of Nephrology, Chronic Renal Failure Research Center, Ahwaz Jundishapur University of Medical Sciences, Ahvaz, Iran
LEAD_AUTHOR
ORIGINAL_ARTICLE
A Comparative Study on the Urine Level of Albumin in Hypertensive Women in Three Groups of Premenopasal, Post Menopauusal and Hystrectomic
Introduction
Hypertension has a high incidence and has several complications. Many studies have been done to reduce these complications. In recent years one of the important factors in hypertensive patients has been albuminuria. Essential hypertension produces clinical proteinuria and a significant reduction in renal function in many patients. The advent of more sensitive method to quantifies the urinary albumin extraction has revealed higher frequency of micro-albuminuria in patients with hypertension than in normotensive population. This wide variability in the incidence of micro-albuminuria in these studies may be related to the severity of hypertension, selection criteria, racial difference and, in some cases, to smaller number of patients studied. It can be different in men and women and also in separate periods of sexual hormone function in women.
Materials and Methods
Three groups of hypertensive women including premenopausal, postmenopausal and hysterectomic referred to Ghaem hospital were selected. Sample size was 125 (for premenopausal 50, postmenopausal 50 and hysterectomic 25). Morning urine analysis of albumin was done by ELISA test.
Results
Mean age was 50.1±10.24 years old. Mean duration of hypertension was 6.6±4.78 years. Mean level of albuminuria was 20.72±21.89. There was no significant difference between three groups for albuminuria (p=0.081), but there was a statistical difference between premenopausal and hysterectomic patients (p<0.001).
Conclusion
It could be said that lack of sexual hormones may be influential for increasing of albuminuria.
https://mjms.mums.ac.ir/article_1229_eda8fabb05849574da8189dc72c0dd07.pdf
2013-07-23
170
176
10.22038/mjms.2013.1229
Albuminuria
hypertension and hysterectomy
Premenopausal
Mahdy
Hassanzade Deluei
hasanzadedaloeem@mums.ac.ir
1
Associated Professor of cardiovascular, cardiovascular Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Mohammad Taghi
Shakeri
shakerimt@mums.ac.ir
2
Associate Professor of Biostatistics, Mashhad University of Medical Sciences, Mashhad, Iran
LEAD_AUTHOR
Niloofar
Sedghi
aminim1@mums.ac.ir
3
General Physician,
Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Solmaz Poor
Gonabadi
4
Pharmacology Student, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Fatemeh
Oraei Ghoddoosi
crc@mums.ac.ir
5
BSc in Microbiology, cardiovascular, cardiovascular Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Maral
Amini
6
MSc in Biochemistry, Mashhad Islamic Azad University, Mashhad Branch, Mashhad, Iran
AUTHOR
ORIGINAL_ARTICLE
Insight of Minor Thalassemia Couples on Abortion of Major Thalassemia Fetus
Introduction
Thalassemia is the most common genetic disorders in the world. There are more than 20.000 beta thalassemia major patients in Iran. Most parts of the world, including Iran, apply a national program of thalassemia prevention. In our country, prenatal diagnosis and pregnancy termination has been an effective program in this area. But some studies do not consider this method appropriate. The aim of this study was to evaluate the attitude of thalassemia minor couples having a thalassemia major fetus.
Materials and Methods
This study was done on 65 thalassemia minor couples having a thalassemia major fetus from January 2008 till February 2009 and both couples answered the questionnaire in a quiet place without a questioner (a person asking question).
Results
The ages of mothers and fathers were 17 to 35 years (24±4.65 years) and 22 to 39 years (30.36±5.23) respectively. All couples except one attempted abortion and all of them were upset of having a thalassemia major fetus.
Conclusion
Although the legal abortion with the approval of religious leaders as long as 16 weeks of gestational age is performed in Iran, and in our study 98.4% of cases had attempted abortion awared of thalassemia major person’s future, but all families were hurt with the happened insident. So, further investigations should be done for the couples’ complications. It is recommended to reduce the physical and psychological complications of couples using PGD method rather than CVS.
https://mjms.mums.ac.ir/article_1230_4c1832c910651ebcbacf89efebda7319.pdf
2013-07-23
177
181
10.22038/mjms.2013.1230
Beta thalassemia major
Beta thalassemia minor couples
Iran
Legal abortion
Hasan
mahmoodi nesheli
1
Assistant professor of pediatric hematology, Bobol University of Medical Sciences, Bobol, Iran
AUTHOR
Naimeh
nakhjavani
2
Assistant professor of pediatrics, Bobol University of Medical Sciences, Bobol, Iran
AUTHOR
Peyman
eshraghi
eshraghip2@mums.ac.ir
3
Assistant professor of pediatric endocrinology, Mashhad University of Medical Sciences, Mashhad, Iran
LEAD_AUTHOR
ORIGINAL_ARTICLE
A Case Report of Speech Disorders Following Bilateral Congenital Abnormality in Globus Pallidus
Introduction Bilateral basal ganglia abnormality, especially in globus pallidus, is a rare disorder of young childhood that can result in variety of problems such as speech disorders. Case report A 7.5 -year-old male child was referred by multiple problems such as disorders of gag reflex and swallowing, voice tremor, monoton speech and weakness of mastication muscles. The patient's MRI scan revealed bilateral focal lesions in the globus pallidus with unclear reason. He had failed to respond to drug treatment, so he went on rehabilitation therapy when his problem progressed. Conclusion Because of their association with cerebral cortex, especially with Broca's area, the basal ganglia can influence the motor features of speech. Probably in the present patient, disturbances in the circuits between the basal ganglia and the language motor area of the cerebral cortex resulted in motor speech disorders. However, more investigations needed to be done.
https://mjms.mums.ac.ir/article_1231_93591feb7cf24278e449a5588b5d343e.pdf
2013-07-23
182
186
10.22038/mjms.2013.1231
Basal ganglia
Globus pallidus
speech disorders
Mohamad Javad
Saeedi Borujeni
saeedimj891@mums.ac.ir
1
MSc of anatomical sciences, Department of anatomical sciences and cell biology, MashhadUniversity of Medical Sciences, Mashhad, Iran
LEAD_AUTHOR
Mehdi
Khodamoradi
2
PhD candidate of neuroscience, neuroscience research center, Kerman University of Medical Sciences, Kerman, Iran
AUTHOR
Hossein
Haghir
haghirh@mums.ac.ir
3
Associate professor of Neuroanatomy, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR