ORIGINAL_ARTICLE
Investigation of Diagnostic Values of hsCRP in Pleural Fluid for Differentiation Tuberculosis and Malignant Pleural Effusion
Pulmonary& TB Research Center
Introduction Pleural effusion is one of the most common and important complications in pulmonology. When the absorption of pleural fluid is less than its secretion, effusion happens and diagnosis between TB and malignant pleural fluid is important. C reactive protein with high sensivity(hsCRP) is secreted by tissue when inflammations is present. The aim of this study was hsCRP[S1] evaluation could help to[S2] differentiate between TB and malignant pleural effusion Materials and Methods 100 patients with TB or Malignant pleural effusion who referred to Emam Reza hospital, Mashhad in 2009 underwent thoracocentesis; then hsCRP with photometry methods were analyzed[S3]. All data were analyzed by SPSS 11 and cutoff point for hsCRP with ROC curve was found. Result Mean age was 53.41 years 19.63 SD. Mean concentration of hsCRP was 9.53 (mg/lit) with SD 5.78 (mg/lit). hsCRP concentration in TB group was13.6±5.6 and in malignant pleural effusion group was 6.00±3.93 (mg/lit). They had[S4]significant different with statistical analysis (P<0.001). Sensitivty of hsCRP to differentiate between TB and malignancy with cutoff point of 8.35(mg/lit) is 92% and specificity is 78%. They had significant different with statistical analysis [S5](P<0.001). Conclusion hsCRP cloud help us to differentiate between TB and malignant pleural effusion.
https://mjms.mums.ac.ir/article_5347_080b96a2584e55192e6d73caf7cf5268.pdf
2011-06-22
69
74
10.22038/mjms.2011.5347
Malignancy
Pleural Effusion
Tuberculosis
Mohammad Reza
Parizadeh
1
Associate professor of biochemistry, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Fariba
Rezaeetalab
rezaeitalabf1@mums.ac.ir
2
Assistant professor of pulmonology, Mashhad University of Medical Sciences, Mashhad, Iran
LEAD_AUTHOR
Ahmad
Marami
3
Resident of Internal Medicine,Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
1- Light RW. Clinical manifestations and useful tests. In: Light RW.editor. Pleural diseases. 3rd ed, Baltimore:
1
Williams and Wilkins;1995.p.36-74.
2
2- Rezaeetalab F, Ghasemie J, Akbari H, Ahmadihoseini H. Serum and Pleural fluid lbumin Gradient in differentiation
3
of Exudative and transudative causes. JMUMS 2007:343-350.
4
3- Bartter T, Santarelli R, Akers SM, Pratter MR. The evaluation of pleural effusion. Chest 1994; 106:1209-1214.
5
4- Escudero BC, Garcia CM, Cuesta CB. Cytologic and bacteriologic analysis of fluid and pleural specimenswith
6
Cope’s needle. Arch Int Med 1990; 150:1190-1194.
7
5- Valdes L, Alvarez D, San Jose E, Juanatey JR, Pose A, Valle JM, et al. Value of adenosine deaminase in the
8
diagnosis of tuberculous pleural effusions in young patients in a region of high prevalence of tuberculosis. Thorax 1995;
9
50:600-603.
10
6- Chierakul N, Kanitsap A, Chaiprasert A, Viriyataveekul R.A simple Creactive protein measurement for
11
differentiation between tuberculosis and malignant pleural effusion. Respirology 2004; 9:66-69.
12
7- Determann RM, Achouiti AA, Elsolh AA, Bresser P, Vijifhuizen J, Spronk PE, et al. Infectious pleural effusion can
13
be identified by sTREM-1 levels. Respir Med 2010; 104:310-315.
14
8- Liu CL, Hsieh WY, Wu CL, Kuo HT. Triggering expressed on myeloid cells-1 in pleural effusion: a marker of
15
inflammatory disease. Respir Med 2007; 101:903-909.
16
9- Kiropoulos TS, Kostikas K, Oikonomidi S, Tsilioni I, Nikoulis D, Germenis A, et al. Acute phase markers for the
17
differentiation of infectious and malignant pleural effusions. Respir Med 2007; 101:910-918.
18
10- Garcia-Pachon E, Soler MJ, Padilla-Navas I, Romero V, Shum C. C-reactive protein in lymphocytic pleural
19
effusions: a diagnostic aid in tuberculous pleuritis. Respiration 2005; 72:486-489.
20
11- Calikoglu M, Sezer C, Unlu A, Kanik A, Tamer L. Use of acute phase proteins in pleural effusion discrimination.
21
Tuberk Toraks 2004; 52:122-129.
22
12- Yildirim Z, Turkoz Y, Biber C, Erdogan Y, Keyf AI. Use of pleural fluid C-reactive protein in diagnosis of pleural
23
effusions. Respir Med 2000; 94:432-435
24
ORIGINAL_ARTICLE
Comparison of Temporary Dialysis Catheter and A-V Fistula Use at the Time of Starting Chronic Hemodialysis among End-Stage Renal Diseases Patients
Introduction The preferred type of access for chronic hemodialysis (HD) is an Arterio-Venous (A-V) Fistula. However most of the ESRD patients does not have a mature fistula at the time of starting HD due to late referral to the nephrologists so the managing physicians have to use temporary catheters with high rate of complications. Materials and Methods In a retrospective study we determined and compared the prevalence of temporary catheters or A-VFistula use at the time of starting chronic HD from November 1995 to June 2009. We have divided our patients in three different groups. Group A: HD patients between 1995-2005, Group B: HD patients between 2006-2007, and Group C: HD patients after 2007. Results A total of 473 ESRD patients (288 male, 185 female; mean age, 55.8± 16.4 years) were included in the study. Causes of ESRD were HTN 34.1%, DM 20. 08%, glomeronephritis 9.72%, obstructive uropathy 8.46%, ADPKD 5.92%, and unknown 21.77%. Overall the prevalence of temporary catheters and A-V Fistula use were 86.5 and 13.5 percent. But the prevalence was different in the studied groups: group A (93.6% and 6.4%), in group B (85.0% and 15.0%) and in group C (67.5% and 29. 5%) respectively. There was a significant increase in A-V Fistula use after 2005 (p=0.00) and especially after 2007 (p=0.000). Conclusion Although there was a significant increment in the A-V Fistula use, it is not still enough and general physicians, nurses and chronic kidney disease patients have to be educated about the benefits of early A-V Fistula creation.
https://mjms.mums.ac.ir/article_5348_21e27d799ea585a21687df965b332ddc.pdf
2011-06-22
75
79
10.22038/mjms.2011.5348
Arterio-Venous Fistula
hemodialysis
Temporary Dialysis Catheter
Seyed Seifollah
Beladi , Mousavi
mrt_tamadon@yahoo.com
1
Assistant Professor of Nephrology, Jundishapur University of Medical Sciences, Ahvaz, Iran
LEAD_AUTHOR
Fatemeh
Hayati
2
Assistant Professor of Nephrology, Jundishapur University of Medical Sciences, Ahvaz, Iran
AUTHOR
Iraj
Neseri
3
Assistant Professor Of Surgery, Jundishapur University of Medical Sciences, Ahvaz, Iran
AUTHOR
Abbas Ali
Zeraati
zeraaty@mums.ac.ir
4
Assistant Professor Of Nephrology, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
1- USRDS: The United States Renal Data System. Excerpts from the USRDS 2008 annual data report: Atlas of endstage
1
renal disease in the United States. Am J Kidney Dis 2009; 1:S1.
2
2- Beladi Musavi SS, Hayati F, Alemzadeh Ansari MJ, Valavi E, Cheraghian B, Shahbazian H, et al. Survival at 1, 3,
3
and 5 Years in Diabetic and Nondiabetic Hemodialysis Patients. Iran J Kidney Dis 2010; 4:74-77.
4
3- Nafar M, Monsavi SM , Mhdavi M , Pour-Reza-Gholi F, Firoozan A, Einollahi B , et al . Burden of Chronic
5
Kidney in Iran. Iran J Kidney Dis 2008; 2:138-192.
6
4- Fan PY. Acute vascular access: New advances. Adv Ren Replace Ther 1994; 1:90.
7
Vanholder R, Lameiere, N, Verbanck J, van Rattinghe R, Kunnen M, Ringoir S.
8
5-Complications of subclavian catheters for hemodialysis: A 5 year prospective study in 257 consecutive patients. Int J
9
Artif Organs 1982; 5:297.
10
6- Lok, CE, Oliver, MJ. Overcoming barriers to arteriovenous fistula creation and use. Semin Dial 2003; 16:189.
11
Asif A, Cherla G, Merrill D, Cipleu CD, Briones P, Pennell P.
12
7- Conversion of tunneled hemodialysis catheter-consigned patients to arteriovenous fistula. Kidney Int 2005; 67:2399.
13
8- Polo JR, Tejedor A, Polo J, Sanabia J, Calleja J, Gó mez F. Long-term follow-up of 6-8 mm brachioaxillary
14
polytetrafluorethylene grafts for hemodialysis. Artif Organs 1995; 19:1181.
15
9- Saad TF. Bacteremia associated with tunneled, cuffed hemodialysis catheters. Am J Kidney Dis 1999; 34:1114.
16
10- Bender MH, Bruyninckx CM, Gerlag PG. The brachiocephalic elbow fistula: a useful alternative angioaccess for
17
permanent hemodialysis. J Vasc Surg 1994; 20:808.
18
11- Coburn MC, Carney WI Jr. Comparison of basilic vein and polytetrafluoroethylene for brachial arteriovenous
19
fistula. J Vasc Surg 1994; 20:896.
20
12-Rodriguez JA, Armadans L, Ferrer E, Olmos A, Codina S, Bartolomé J ,et al. The function of permanent vascular
21
access. Nephrol Dial Transplant 2000; 15:402.
22
13- Vascular access use in Europe and the United States: Results from the DOPPS. Kidney Int 2002; 61: 305–316.
23
14- Ethier J, Mendelssohn DC, Elder SJ, Hasegawa T, Akizawa T, Akiba T, et al. Vascular access use and outcomes:
24
an international perspective from the dialysis outcomes and practice patterns study. Nephrol Dial Transplant 2008;
25
23:3219-32 26.
26
15- Cruz JM, Piera L, Bragg-Gresham JL, Feldman H, Port FK. Results of the international hemodialysis study DOPPS
27
in Spain and Europe. Nefrologia 2003; 23:437-443.
28
16- Fan PY. Acute vascular access: New advances. Adv Ren Replace Ther 1994; 1:90.
29
17- Sottiurai VS, Stephens A, Champagne L, Moradeshagi P, Frey D, Reisin E. Comparative results of early and
30
delayed cannulation of arteriovenous graft in haemodialysis. Eur J Vasc Endovasc Surg 1997; 13:139.
31
18- Rayner HC, Pisoni RL, Gillespie BW, Goodkin DA. Creation, cannulation and survival of arteriovenous fistulae:
32
Data from the Dialysis Outcomes and Practice Patterns Study. Kidney Int 2003; 63:323.
33
19- Saran R, Dykstra DM, Pisoni RL, Akiba T, Akizawa T, Canaud B, et al. Timing of first cannulation and vascular
34
access failure in haemodialysis: an analysis of practice patterns at dialysis facilities in the DOPPS. Nephrol Dial
35
Transplant 2004; 19:2334.
36
20- Oliver MJ, Rothwell DM, Fung K, Hux JE, Lok CE. Late creation of vascular access for hemodialysis and
37
increased risk of sepsis. J Am Soc Nephrol 2004; 15:1936
38
ORIGINAL_ARTICLE
A Comparison of Serum Level of Selenium in Women with Preeclampsia and Normal Pregnant Women
Introduction Preeclampsia is a common complication of pregnancy with the prevalence of 2-7% which increases fetal-maternal mortality. Despite many researches in this field, the etiology of preeclampsia is still unknown and different theories are suggested. Recently the role of deficiency of trace elements is emphasized. Selenium is one of the trace elements which as an antioxidant play an important role in protection of endothelial cells of blood vessel with counterbalancing of oxygen free radicals. The aim of this study was to compare serum level of selenium in women with preeclampsia and normal pregnant women. Materials and Methods This cohort study was performed on 35 women with severe preeclampsia as case group and 30 normal pregnant women as control group in Emam Reza Hospital during 2007-2009. Two groups were matched in terms of maternal age, gestational age, and BMI. Serum level of selenium was measured by spectrophotometer with method of atomic absorption. Data was analyzed with SPSS software version 18 and T-student test. P≤0.05 was considered statistically significant. Results The mean serum level of selenium was significantly decreased in preeclamptic women compared to the healthy pregnant women (P<0.05). In preeclampsia group, pregnancy outcomes were worse in women with lower selenium level. Conclusion This study showed that severe preeclampsia is related with decreased concentration of selenium; early measurement of this element can be useful for early prediction of preeclampsia.
https://mjms.mums.ac.ir/article_5349_ec89a4d634f2b80adea01b0e8b91e620.pdf
2011-06-22
80
85
10.22038/mjms.2011.5349
Normal pregnancy
Preeclampsia
Selenium
Neda
Davaryari
1
General Physician, Mashhad University of Medical Sciences, Mashhad, Iran
LEAD_AUTHOR
Ramin
Razavi Panah
2
General Physician, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Safoura
Homayoon Mehr
3
General Physician, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Homa
Oskouiyan
4
Assistant Professor of Gynecology, Mashhad Islamic Azad University, Mashhad, Iran
AUTHOR
Marzieh
Mohajeri
5
Assistant Professor of Gynecology, Mashhad Islamic Azad University, Mashhad, Iran
AUTHOR
Nayereh
Ghomian
6
Associated Professor of Gynecology, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Seyed Mohsen
Ghasemi
7
MPH, Statistics, Mashhad Islamic Azad University, Mashhad, Iran
AUTHOR
1- Gibbs R, Karlan BY, Hanay SF, Nygard I. Hypertensin disease of pregnancy. In: Sibai BM, Habli M. Danforth's
1
obsetetrics & Gynecology.10thed. Lippencat& willksins; 2008.p.258-359.
2
2- Cunnigham FG, Leveno KJ, Mac Donald P, Bloum SL. Physiology of pregnancy. In: Williams obstetrics. 23th ed
3
.NewYorc: McGraw hill Com;2010.p.756-785.
4
3- Atamer Y, Kocygit Y,Yokus B, Atamer A, Erden AC. Lipid preeclampsia. Eur J Obstet Gynecol Repord Biol
5
2005; 119:60-66.
6
4- Rayman MP, Bodo P, Redman CW. Low Selenuim status is associated with occurrence of the pregnancy disease
7
preeclampsia in UK women. Am J Obstet Gynecol 2003; 189:1343-1349.
8
5- Iihan N, Simesek M. The change of trace elements, malondialdehyde levels and superoxide dismutase activities
9
in pregnancy without preeclampsia. Clin Biochem 2002; 35:393-397.
10
6- Mahomed K, Williams MA, Woelk GB Mudzamiri S, Madzime S, King IB,et al. Leukocyte selenium, zinc, and
11
cooper concentration in preclamptic and normotensive pregnant weman. Biol Trace Elem Res 2000; 75:107-111.
12
7- Orhan H, Onderoglu L, Yucel A. Circulationg biomarker of oxidative stress in complicated pregnancies. Arch
13
Gynecol Obstet 2003; 267:189-95.
14
8- Reyman MP. Selenoproteins and human health. Biochim Biophys Acta 2009; 1790:1533-1540.
15
9- Mistry HD,Wilson V,Romsay MM,Symonds ME,Broghtn PF.Reduced Selenium concentrations and glutation
16
peroxidase activity in preeclampic pregnancy. Hypertension 2008; 52:881-888.
17
10- Briceno PC, Bricono SL, Vigil DG. Prediction & prevension of preeclopicia. Hypertens Pregnancy 2009;
18
28:138-155.
19
11- Rumiris D,Purwosuna Y,Wibowo N,Farina A,Sekizawa A. Lower rate of preeclampsia after antioxidant
20
supplementation in pregnant women with low antioxidant status.Hypertens pregnancy 2006; 25:241-253.
21
ORIGINAL_ARTICLE
Opium Abuse among Patients with Chronic Physical Pain as a Misleading Cause in Addiction Treatment Center
Introduction Chronic non-cancer pain has been considered as causes of Opium addiction in human beings. The knowledge of its incidence as an initial reason for Opium consumption among Opium addict people may affect a) addiction prevention plans, b) addiction treatment programmes and even 3) educational goals for training medical students. Therefore,this study aimed to determine this incidence among Opium addict people referred to an addiction treatment center. Materials and Methods This is a cross sectional study which was performed in Ahwaz during 2006-2008.First, a pilot study was carried out in which the study sample size was calculated. Participants were evaluated by physical examination, pain scaling via VAS, physical examination and psychological interview based on DSM4 criteria and SCL90 questionnaire. The obtained data were analyzed by descriptive analysis of SPSS and χ square test. Results Finally, 21 patients out of 224 participants were found to suffer from a type of chronic physical pain before Opium addiction. Psychological abnormalities were more frequent in pain suffered patients (p<0.007). Conclusion There were some people who seek for getting rid of physical pain. But, they were deviating to a street drug abuse status. This issue should be considered in prevention and treatment of addiction.
https://mjms.mums.ac.ir/article_5350_f8485b68bc8358b552aadc9ba6373abd.pdf
2011-06-22
83
93
10.22038/mjms.2011.5350
Addiction treatment
Chronic physical pain
Drug abuse
Seyed Reza
Saeidian
1
Assistant professor of Physical Medicine and Rehabilitation, Jundishapur university of Medical sciences, Ahvaz, Iran
LEAD_AUTHOR
Soraya
Ashrafizadeh
2
MPH &Lecturer in public health, Jundishapur university of Medical Sciences, Ahvaz, Iran
AUTHOR
Siroos
Pakseresht
3
Assistant professor of psychiatry, Jundishapur University of Medical sciences, Ahvaz,Iran
AUTHOR
Mehdi
saiiah bargard
sayah_bargard@hotmail.com
4
Assistant professor of psychiatry, Jundishapur University of Medical sciences, Ahvaz,Iran
AUTHOR
1- Seifollahi H. The evaluation of addicted women social and economical status whom were arrested in Tehran. Ann
1
Res J Shahid Behshti Univ Med Sci 1994; 15-20.
2
2- Ashrafi Zadeh S. The evaluation of economical and social factors affecting 15-20 years old young people to be
3
afflicted in addiction in Ahwaz. The report of a research project in Ahwaz Jundishapour University of Medical
4
Sciences. 2003; 60-87.
5
3-Momtazi S. Families and addiction. Economical and social problems among families Tehran. 2002; 101-140.
6
4- Jackson T. Acute and chronic pain-in: practical manual of physical medicine and rehabilitation. Mosby; 1998p.607-644.
7
5- Goldman B. Acute pain in: Managing Pain. Health Care &Financial publishing, Rogers's media; 2002.p.87-103.
8
6- Taub A. Opioid analgesics in the treatment of chronic intractable pain of non-neoplastic origin. In: Kitahatalin,
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collins D. Narcotic analgesics in anaesthesidogy. Baltimore:Williams&Willkins; 1982;.p.199-208.
10
7- France R, Urban B, Keefe F. Long term use of narcotic analgesics in chronic pain. Soc Sci Med 1984:1379-82.
11
8- France R, Urban B, Keefe F. Long term use of narcotic analgesics in chronic pain.J Pain Symp Manage 1992;7:69-77.
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9- Tennant J, Robinson D, Sagherian A , Secaf R. Chronic opioid treatment of intractable non- cancer pain. NIDA Res
13
Manogr 1988; 81:174-180.
14
10- Portenoy R. Opioid therapy for chronic non – malignant:A review of the Critical Issues. Pain Res manage 1996;
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11:203-217.
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11- Strumpf M, Tryba M. long term oral opioid therapy in patient with chronic non-malignant pain. J pain symp
17
manage 1992; 7:69-77.
18
12- Arkinstall W, Sandler A,Geoghnour B, Babul N, Horsanyi Z, Darke A. Efficacy of controlled- release codein in
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chronic non-malignant pain: a randomized, placebo – controlled clinical trial . Pain 1995; 62:196-178.
20
13- Peloso PM, Bellamy N, Bensen W, thomson GT,Harsonyiz Babul N, Darke AC. Double blind randomised
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Placebo controutrial of controlled release codein in the treatment of osteoarthritis of the hip or knee. J
22
Rheumatol 2000; 27:764-771.
23
14- Noorbala A, Fakhraie S. Surveying the frequency of psychiatric symptoms among senior medical and nonmedical
24
students of Tehran University. J Thought Behav 2001; 30-38.
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15- Kaviani H, Moosavi A, Moin A. Psychological interview and tests. Fana 1388; 250-255.
26
16- Mailis GA. Opioid use And Abuse: Is There a problem? Clin J Pain 2007; 23: 661-662.
27
17- Mercadante S. Opioid rotation for cancer pain: rationale and clinical aspects. Cancer 1999; 86:1856 -1866.
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18- Mancini I, Lossignol D, Body J. Opioid switch to oral methadone in cancer pain. Curr Opin Oncol 2000; 12:308 -313.
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19- Quigley C. Opioid switching to improve pain relief and drug tolerability. Cochrane Database Syst Rev 2004;
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:CD004847.
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20- Morita T,Takigawa C, Onishi H, Tsukasa T, Kazuhiko T, Tatsuhiko M, et al. Opioid rotation from morphine to
32
fentanyl in delirious cancer patients. J Pain Symp Manage 2005; 30:96-103
33
21- Rettig R, Yarmolinsky A. eitors. Federal regulation of methadone treatment. In: The committee report on
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federation regulation of methadone treatment. Washington, DC: The National Academic Press; 1995.p.88-112.
35
22- Morgan J, Pleet D. Opioidphobia in the United States: the under-treatment of severe pain. In: Morgan J, Kagan D,
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editors. Society and medication: conflicting signals for prescribers and patients. Lexington: Lexington Press; 1983.p. 3343.
37
23- Melzack R. The tragedy of needless pain. Science 1990; 262:27–33.
38
24- Roman D. Barriers to Opium Pain Management. In: Managing Pain. Toronto: Health Care and Financial
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Publishing; 2002.p.1-6.
40
25- Bell K, Salmon A. Pain, physical dependence and pseudoaddiction: Redefining addiction for nice people? Int J
41
Drug policy 2009; 20:170-178.
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26- Lusher J, Elander J, Bevan D, Talfer P, Burton B. Analgesic addiction and pseudoaddiction in painful chronic
43
illness. Clin J Pain 2006; 22:316-324.
44
27- Shahri G, Tahsildoost F, Samadi Ahari M, Kakai Afshar H, Rahimi Esfahani A. Psycho trope drugs. In: The
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Iranian penal code. Vol 2. Tehran; Vice chairman in judicature; 2009.p.1465-1473.
46
28-Mailis-Gagon A.What's hurting Alex? In: Mailis-Gagon A, Israelman D. Beyond Pain. 2ed ed. University of
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Michigan Press; 2005.p.21-40.
48
29- Price S. Osteoarthritis: A single genetic factor determines propensity to report musculoskeletal pain at multiple
49
sites. Nat Rev Rheumatol 2010; 6:438.
50
30- Nissenbaum J, Devor M, Seltzer Z, Gebauer M, Michaelis M, Tal M, et al. Susceptibility to chronic
51
pain following nerveinjury is genetically affected by CACNG2.Genome Res. Available
52
at:www.genome.org/cgi/doi/10.1101/gr.104976.110(2010).
53
ORIGINAL_ARTICLE
The Outcome of Transanal Anorectal Myectomy in the Patients with Ultrashort_Segment Hirschsprung`s Disease
Introduction Anorectal myectomy and anal dilation under anesthesia could be an effective way in the treatment of patients with ultrashort_segment Hirschprung.In this article we studied [S1]the outcomes of anorectal myectomy. Materials and Methods Our study group was [S2]61 patients with the disease who had reffered to SHEIKH hospital from the second half of 1386 to the first half of 1388. Barium enema and anorectal myectomy was performed in all patient[S3].Follow up after myectomy was in the second week after surgery and then monthly[S4].For the complications and results, patients were also divided in to 3 groups based on the presence or absence of ganglion cell in the muscular resectal region,and the results were compared in each [S5]group. Results Bleeding, infection of the operation zone, sepsis, entrocolitis, and anal stenosis was not observed in any patient after surgery. 4 patients had gas incontinence and 3 had fecal incontinence after surgery which was cured in 3-6 months with bio-feedback orders. 40 patients (87.5%) had complete remission after surgery and 2(4.17%) had partial remission and 4(8.33%) had no remission at all. Based on these results, there is no relation between gender, complications of surgery and the results of surgery. Conclusion Anorectal myectomy could be an effective treatment strategy for patients with following situations: absence of anatomical abnormalities-[S6]chronic constipation in spite of medical treatment-[S7]absence of transitional zone in barium enema-[S8]failure of anorectal reflex relaxation with rectal distention in anorectal manometry.
https://mjms.mums.ac.ir/article_5351_5663517d61c80a1b4781137b5628e2d9.pdf
2011-06-22
94
99
10.22038/mjms.2011.5351
Hirschprung disease
Trans anorectal myectomy
ultrashort segment
Marjan
Joudi
1
Assistant professor of Pediatric Surgery, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Mehran
Hiradfar
2
AssociatedProfessor of Pediatric Surgery, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Mehdi
Fathi
3
Assistant professor of Anesthesia, Mashhad university of Medical Sciences, Mashhad, Iran
LEAD_AUTHOR
Mona
joudi
4
Medical doctor
AUTHOR
1- Langer JC,Minkes RK, Mazziotti MV, Skinner MA, Winthrop AL. Transanal one-stage Soave procedure for infants
1
with Hirschsprung disease.J Pediatr Surg 1999; 34:148-152.
2
2- Oneil JA, Rowe MI, Grosfeld JA, Fonkalsrud EW, Coron AG.Pediatric Surgery.5thed.1998.
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3- Oldham KT, Colombani PM, Robert P. Principles and practice of pediatric surgery.Lippincott Williams and Wikins; 2005.
4
4- Keith W,Ashcrraft J, Marphy P, Sharp RJ, Sigalf DL. Ashcraft pediatric surgery.3rd ed.W.B Saunders company; 2000.
5
5- Sharma LK, Marya RK, Chandran AP. Rectal Prolaps in childhood.A new sign of ultrashort segment. Hirshprung
6
disease? Indian pediatr 1984; 21:155-158.
7
6- Meier-Ruge W. Ultrashort segment. Hirshprung disease: An objective picture of disease substantiated by biopsy. Z
8
Kinderchir 1985; 40:146-150
9
7- Ohi R,Yamaggychi M,Komatsu k,Kato H,Kasai M.Diagnosis of Hirshprung disease:2 point rectal mucosal biopsies
10
for selection of surgical treatment. Nippon Geka Gakkai Zasshi 1985; 86:1281-1283.
11
8- Campobasso P,Salano F,Cimaglia ML,Cappellari F,Scalabrin U. Hirshprung disease:Results of surgical treatment.
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Pediatr Med Chir 1986; 8:659-664
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9- Joseph VT,Sim CK.Experience in the surgical management of Hirshprung disease. Ann Acad Med Singapore 1987;
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16:518-526.
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10- Campabosso P,Belloli G.Chronic constipation in children. Pediatr Med Chir 1988; 10:241-250.
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11- Problems and pitfalls in the management of Hirshprung disease.J Pediatr Surg 1988; 23:398-402.
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12- Neilson IR,Yazbeck S.Ultrashort segment.Hirshprung disease. Myth or reality. J Pediatr Surg 1990 ; 25:1135-1138.
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13-Watanatittan S, Suwatanaviroj A, Limprutithum T. Association of Hirshprung disease and anorectal malformation. J
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Pediatr Surg 1991; 26:192-195.
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14- De Caluwe D, Yoneda A, Aki U, Puri P. Internal and sphincter ashalasia:Outcome after internal sphincter
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myectomy.J Pediatr Surg 2001; 36:736-738.
22
15- Sancandi M, Ceccherini I, Costa M, Fava M, Chen B, Wu Y, et al. Incidence of RET mutations in patients with
23
Hirshprung disease.J Pediatr Surg 2000; 35:139-142.
24
16- Moore BG, Singaram C, Eckoff DE, Gaumnitz EA, Staling JR. Immunohistochemical evaluation of ultrashort
25
segment.Hirshprung disease.Report of three cases. Dis Colon Rectum 1996; 39:817-820.
26
17- Ballard ET. Ultrashort segment.Hirshprung disease.A case report. Pediatr Pathol Lab Med 1996; 16:319-325.
27
18- Skopnik H, Bedut U, Steinau G, Meier Ruge W, Habedank M. Hirshprung disease. Paternal transmission to a son.
28
Eur J Pediatr 1993; 152:467-468.
29
19- Mohamed I, EL-Sawaf, Robert A, Drongowski, Jennifer N, Chamberlain, et al. Are the long-term results of the
30
transanal pull-through equal to those of the transabdominal pull-through?A comparison of the 2 approaches for
31
Hirshprung disease.J Pediatr Surg 2007; 42:41-47.
32
20- Amiel J, Sproat-Emison E, Garcia-Barcelo M. Hirschsprung disease, associated syndromes and genetics.J Med
33
Genet 2008; 45:1-14.
34
21- Srivastava P,Upadhyaya VD,Gangopadhyaya A,Hasan Z, Upadhyaya A, Kumar V.Comparison of two techniques
35
for single_stage treatment of Hirschsprung disease in neonates. Int J Surg 2008; 17.
36
22- Hadidi A, Bartoli F,Waag K. Role of transanal endorectal pull-through in complicated Hirschsprung`s
37
disease:experience in 18 patients. J Pediatr Surg 2007; 42:544-548.
38
23- Osifo OD, Okolo CJ.Outcome of trans-anal posterior anorectal myectomy for the ultrashort segment Hirschsprung`s
39
disease-Benin city experience in five years. Niger Postgrad Med J 2009;16:213-217.
40
24- Bruder E, Terracciano LM, Passarge E, Meier-Ruge WA.Enzyme histochemistry of classical and ultrashort
41
Hirschsprung`s disease. Pathol J 2007; 28:105-112.
42
25- Menezes M,Corbally M,Puri P. Long term results of bowel function after treatment for Hirschsprung`s
43
disease: a 29- year review.Pediatr Surg Int 2006; 22:987-990.
44
26- Wildhaber B, Coran AG, Teitelbaum DH. Total colonic Hirschsprung`s disease:a 28 year experience. Pediatr Surg J
45
2005; 40:203-206.
46
27-Wildhaber B, Pakarinen M, Rintala R, Coran AG, Teitelbaum DH. Posterior myotomy/myectomy for persistent
47
stooling problems in Hirschsprung`s disease. Pediatr Surg J 2004; 39:920-926.
48
ORIGINAL_ARTICLE
A Study of Two Months Walking Exercise on Serum Lipoprotein and Body Mass Index in Obese Girls
Introduction Obesity, a public health problem is growing [S1]in prevalence over the recent decade. One morbidity[S2] associated with obesity is cardiovascular disease (CVD) which is invariably related to dyslipidaemia. The purpose of the present study is to examine the effect of walking exercise in order to reduce the risk of (CVD) in sedentary obese girls. Materials and Methods Twenty untrained obese (BMI>30) girls with age 22.00 ± 1.50 years volunteer took [S3]place in this research and then they were randomly divided in two groups (Control: n=10 Experimental: n=10). At first and after 2 months HDL-c, LDL-c and BMI were assessed[S4]. Then the experimental group started to do exercise programme. The data by[S5] unpaired- t-test at the level of pResults The study finding showed that reduced [S6]BMI (p=0.001), LDL-c (p=0.006)significantly decreased but HDL-c (p=0.004) significantly increased in exercise[S7] group. Conclusion This study demonstrated that a programme of regular physical activity such as walking exercise significantly can[S8] change the lipoprotein's metabolism in body and reduce the risk of (CVD) in obese girls.
https://mjms.mums.ac.ir/article_5352_4ebda25352c6a30498830c3f74440562.pdf
2011-06-22
100
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10.22038/mjms.2011.5352
Body mass index
Obese Girls
Serum Lipoprotein
Walking exercise
Nasim
Habibzadeh
1
MSc in Physiology, Azad Islamic University, Rasht, Iran
LEAD_AUTHOR
Farhad
RahmaniNia
frahmani2001@yahoo.com
2
Professor ofPhysiology, Azad Islamic University, Rasht, Iran
AUTHOR
1- Langer JC,Minkes RK, Mazziotti MV, Skinner MA, Winthrop AL. Transanal one-stage Soave procedure for infants
1
with Hirschsprung disease.J Pediatr Surg 1999; 34:148-152.
2
2- Oneil JA, Rowe MI, Grosfeld JA, Fonkalsrud EW, Coron AG.Pediatric Surgery.5thed.1998.
3
3- Oldham KT, Colombani PM, Robert P. Principles and practice of pediatric surgery.Lippincott Williams and Wikins; 2005.
4
4- Keith W,Ashcrraft J, Marphy P, Sharp RJ, Sigalf DL. Ashcraft pediatric surgery.3rd ed.W.B Saunders company; 2000.
5
5- Sharma LK, Marya RK, Chandran AP. Rectal Prolaps in childhood.A new sign of ultrashort segment. Hirshprung
6
disease? Indian pediatr 1984; 21:155-158.
7
6- Meier-Ruge W. Ultrashort segment. Hirshprung disease: An objective picture of disease substantiated by biopsy. Z
8
Kinderchir 1985; 40:146-150
9
7- Ohi R,Yamaggychi M,Komatsu k,Kato H,Kasai M.Diagnosis of Hirshprung disease:2 point rectal mucosal biopsies
10
for selection of surgical treatment. Nippon Geka Gakkai Zasshi 1985; 86:1281-1283.
11
8- Campobasso P,Salano F,Cimaglia ML,Cappellari F,Scalabrin U. Hirshprung disease:Results of surgical treatment.
12
Pediatr Med Chir 1986; 8:659-664
13
9- Joseph VT,Sim CK.Experience in the surgical management of Hirshprung disease. Ann Acad Med Singapore 1987;
14
16:518-526.
15
10- Campabosso P,Belloli G.Chronic constipation in children. Pediatr Med Chir 1988; 10:241-250.
16
11- Problems and pitfalls in the management of Hirshprung disease.J Pediatr Surg 1988; 23:398-402.
17
12- Neilson IR,Yazbeck S.Ultrashort segment.Hirshprung disease. Myth or reality. J Pediatr Surg 1990 ; 25:1135-1138.
18
13-Watanatittan S, Suwatanaviroj A, Limprutithum T. Association of Hirshprung disease and anorectal malformation. J
19
Pediatr Surg 1991; 26:192-195.
20
14- De Caluwe D, Yoneda A, Aki U, Puri P. Internal and sphincter ashalasia:Outcome after internal sphincter
21
myectomy.J Pediatr Surg 2001; 36:736-738.
22
15- Sancandi M, Ceccherini I, Costa M, Fava M, Chen B, Wu Y, et al. Incidence of RET mutations in patients with
23
Hirshprung disease.J Pediatr Surg 2000; 35:139-142.
24
16- Moore BG, Singaram C, Eckoff DE, Gaumnitz EA, Staling JR. Immunohistochemical evaluation of ultrashort
25
segment.Hirshprung disease.Report of three cases. Dis Colon Rectum 1996; 39:817-820.
26
17- Ballard ET. Ultrashort segment.Hirshprung disease.A case report. Pediatr Pathol Lab Med 1996; 16:319-325.
27
18- Skopnik H, Bedut U, Steinau G, Meier Ruge W, Habedank M. Hirshprung disease. Paternal transmission to a son.
28
Eur J Pediatr 1993; 152:467-468.
29
19- Mohamed I, EL-Sawaf, Robert A, Drongowski, Jennifer N, Chamberlain, et al. Are the long-term results of the
30
transanal pull-through equal to those of the transabdominal pull-through?A comparison of the 2 approaches for
31
Hirshprung disease.J Pediatr Surg 2007; 42:41-47.
32
20- Amiel J, Sproat-Emison E, Garcia-Barcelo M. Hirschsprung disease, associated syndromes and genetics.J Med
33
Genet 2008; 45:1-14.
34
21- Srivastava P,Upadhyaya VD,Gangopadhyaya A,Hasan Z, Upadhyaya A, Kumar V.Comparison of two techniques
35
for single_stage treatment of Hirschsprung disease in neonates. Int J Surg 2008; 17.
36
22- Hadidi A, Bartoli F,Waag K. Role of transanal endorectal pull-through in complicated Hirschsprung`s
37
disease:experience in 18 patients. J Pediatr Surg 2007; 42:544-548.
38
23- Osifo OD, Okolo CJ.Outcome of trans-anal posterior anorectal myectomy for the ultrashort segment Hirschsprung`s
39
disease-Benin city experience in five years. Niger Postgrad Med J 2009;16:213-217.
40
24- Bruder E, Terracciano LM, Passarge E, Meier-Ruge WA.Enzyme histochemistry of classical and ultrashort
41
Hirschsprung`s disease. Pathol J 2007; 28:105-112.
42
25- Menezes M,Corbally M,Puri P. Long term results of bowel function after treatment for Hirschsprung`s
43
disease: a 29- year review.Pediatr Surg Int 2006; 22:987-990.
44
26- Wildhaber B, Coran AG, Teitelbaum DH. Total colonic Hirschsprung`s disease:a 28 year experience. Pediatr Surg J
45
2005; 40:203-206.
46
27-Wildhaber B, Pakarinen M, Rintala R, Coran AG, Teitelbaum DH. Posterior myotomy/myectomy for persistent
47
stooling problems in Hirschsprung`s disease. Pediatr Surg J 2004; 39:920-926.
48
ORIGINAL_ARTICLE
Brain Computed Tomography Scan in Meningitis Patients with Deterioration Of Consciousness
Introduction Due to life-threatening complication of LP in patients with deterioration of consciousness due to meningitis (=brain herniation) the LP procedure safety without brain CT scan is debated. Materials and Methods This descriptive cross-sectional study was done on patients suspected of meningitis with decreased consciousness referred to the infectious emergency of Emam Reza Hospital, Mashhad, Iran from April 2006 to March 2008. All patients underwent physical examination (neurologic and ophthalmoscopic) of the patients by residents of infectious diseases. Data (results of physical examination, neurologic, ophtalmoscopic, brain CT scan and LP) were collected. Then statistical analysis was performed with SPSS software and descriptive statistical methods. Results 136 patients were evaluated. The mean age of patients was 43.88±21.185 years and 58.5% (24) of the cases were male. The result of brain CT was normal in 53.7%. The most frequent abnormal brain CT results were hypodencity lesions (12%). 2.4 % (1) of patients had abnormal CT-Scan with space occupying lesion with mass effect and midline shift, and final diagnosis was brain abscess due to chronic mastoiditis. Conclusion This study showed that abnormal finding of brain CT-Scan in adult meningitis with loss of consciousness is approximately 50% and mass effect was seen in 2.4% of patients
https://mjms.mums.ac.ir/article_5353_0adcd6d2fe852d4d3124827b89b61b8d.pdf
2011-06-22
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10.22038/mjms.2011.5353
Abnormal consciousness
Brain CT Scan
LP
Meningitis
Ashraf
Tavanaee Sani
1
AssociateProfessor of Infectious Diseases Mashhad University of Medical Sciences, Mazandaran, Iran
AUTHOR
Donya
Farokh
farrokhd@mums.ac.ir
2
Associate Professor of Radiology,Mashhad University of Medical Sciences,Mashhad, Iran
AUTHOR
Hamidreza
Naderi
naderihr@mums.ac.ir
3
Assistant Professor of Infectious Diseases Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Habibollah
Esmaeili
4
Associate Professor of Biostatistics,Mashhad University of Medical Sciences,Mashhad, Iran
AUTHOR
Simin
Abasian
5
Assistant of Infectious Diseases,Mashhad University of Medical Sciences,Mashhad, Iran
AUTHOR
Khosro
Mohamadi
mohamadikh@mums.ac.ir
6
Assistant of Infectious Diseases,Mashhad University of Medical Sciences,Mashhad, Iran
LEAD_AUTHOR
1- Allan R, Tunke l. Approach to the patient with central nervous system infection. In: Principles and Practice of
1
Infectious Diseases. Gerald LM, John EB, Raphael Dolin. 7th ed. Churchil Livingston Elsevier:2010.p.1184.
2
2- Ghasemi Sh, Cherei A, Moghimi A, Ehsanabaie A, Biganeh A. Frequency, ethiology and prognosis of meningitis in
3
Firozabady Hospital, Tehran, 1996-98. Rahavard-e-Danesh J 2000; 3:25.
4
3- John E. Greenlee- Bacterial Meningitis, Neurology and clinical Neuroscience. Anthology H. V. Schapira, Edward
5
Byrne-Salvatore Dimoiaro. Philadelphia: Mosby; 2007.p.1238-1239.
6
4- Hasbun R, Abrahams J, Jekel J, Quagliarello V. Computed tomography of the head before lumbar puncture in adults
7
with suspected meningitis N. Engl J Med 2001; 345:1727-1733.
8
5- Allan R, Tunke l. Approach to the patient with central nervous system infection. In: Gerald L, Mandell, John E.
9
Principles and Practice of Infectious Diseases. Bennett Churchil Livingston Elsevier; 2010.p.1191.
10
6- www.irimc.org/magazines/viewsection.aspx?id=4845(1-9).
11
7- Menkes JH, Sarnat HB, Moser FG. Introduction : Neurologic Examination of the Child & Infant. In: Menkes JH,
12
Sarnet HB. Child Neurology. 6th ed. Philadelphia: Lippinocott Williams & Wilkins; 2000.p.1-32.
13
8- Weber C, Grzyska V, Lehner E, Adam G.Clinical relevance of cranial CT under emergency conditions- basic
14
neuroradiologic investigation. Rofo 2003; 175:654-662.
15
9- Rasolinegad MB, Mohsenpor M, Hajabdolbaghi M. Evaluation of clinical sign accuracy in Diagnosis of contraindicated
16
lesions for L.P. in Suspected Acute meningitis for L.P. in suspected Acute Meningitis. TUMS J 2004; 2:39-43.
17
10- Walter L, Olson. Central Nervous System infections. In: William E, Brant Clyde A. Fundamentals of Diagnostic
18
Radiology. 3th ed. Philadelphia: Lippincol-Williams & Wilkins; 2007.p.158.
19
11- Avrum N, Stephen M, Henesch, Lucy B, Rork A. Brain Infections, Caffey's pedriatirc Diagnostic Imaging. 11th ed.
20
Philadelphia: Mosby Elsevier; 2008.p.751.
21
12- Verma A. Infections of the Nervous system. In: Bradley WG, Darof RB, Femichel GM. Neurology in clinical
22
practice. 5th ed. Elsevier; 2008.
23
13- Fallah R, Abedi M. The evaluation of children brain CT Scan results and it's relationship with requesting clinical
24
complaints ofogh-e-Danesh. GMUHS J 2008; 14:28-32.
25
14- Taghavi MR, Heydari AA, Hashemi J. Brain computed tomography scan necessity before lumbar puncture in
26
meningitis patients with more than 60 years age. J Mashhad Univ Med Sci 2007; 50:81-88.
27
15- Tuncer O, Caksen H, Arslan S, Atas B, Uner A. Cranial computed tomography in purulent meningitis of childhood.
28
Int J Neurosci 2004; 114:164-174.
29
16- Khoda Panahandeh F, Hadizadeh H. Neuro imaging in children with first afebrile seizure: to order or not to order?
30
Arch Iran Med 2006; 9: 156-8.
31
17- Haehnel S. Inflammation. In: Sartar K, Haehnel S, Kress B. Direct Diagnosis in Radiology Brain Imaging. Geary
32
Thieme Verlay KG Germany; 2008.p.39.
33
18- Hasbun R. Computed tomography of the head before lumbar puncture in adult with suspected meningitis. 2001;
34
345:1727-1733.
35
19- Gopal Ak, Whitehouse JD, Simel DL, Corey GR. Cranial computed tomography before lumbar puncture: a
36
prospective clinical evaluation. Arch Int Med 1999; 159:2681-2685.
37
ORIGINAL_ARTICLE
Influence of various factors on Response to Streptokinase therapy for acute myocardial Infarction
Introduction Prevalence of ischemic heart diseases, especially acute myocardial infarction and its incidence in lower age has increased and treatment during the acute phase of myocardial infarction plays an important role in the prognosis and quality of life. In our study, we aimed to evaluate the effects of streptokinase on treatment of acute myocardial infarction based on different variables. Materials and Methods In our study, we evaluated patients with acute myocardial infarction who received streptokinase. Information obtained from patients based on patient examination, ECG findings (before and after drug administration) and the results of relevant laboratory tests, then entered in the relevant checklist. Criteria for response to drug were reduced chest pain with at least 50 percent reduction in ECG ST Elevation in electrocardiography taken 30 or 90 minutes after the Streptokinase therapy Results Relation between age (P<0.001), LDL (0.001), diabetes mellitus (P=0. 01), location of MI (P=0.001), Killip Class (P<0.001), patients referring delay (P<0.001) and the effect of streptokinase were significant. While gender, hypertension, smoking, previous ischemic heart disease, time of symptoms onset and type of streptokinase didn’t affect significantly the response to streptokinase. Conclusion Considering our results, patients with acute MI less than 30 years and more than 80 years, diabetics, LDL more than 100mg/dl, extensive anterior MI, new LBBB, Killip Class 3 or 4 and delay of referring more than 12 hours predict poor response streptokinase, and may benefit more from early invasive strategy than thrombotic therapy.
https://mjms.mums.ac.ir/article_5354_74348458b8b2c0f2f8e52872796cb79c.pdf
2011-06-22
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10.22038/mjms.2011.5354
Acute myocardial infarction
Risk factors
Streptokinase
Thrombolytic therapy
Mashalah
Dehghani
1
Professor of Cardiology, Mashhad University of Medical Science,Mashhad, Iran
AUTHOR
Ali
Eshraghi
eshraghia@mums.ac.ir
2
Cardiologist,Mashhad University of Medical Sciences,Mashhad, Iran
AUTHOR
Mohamad Taghi
Shakeri
shakerimt@mums.ac.ir
3
Associate Professor of Biostatistics,Mashhad University of Medical sciences,Mashhad, Iran
AUTHOR
Azadeh
Fallah Rastgar
4
Cardiologist,Mashhad University of Medical Sciences,Mashhad, Iran
LEAD_AUTHOR
Golnaz
Hoshmand
5
Cardiologist,Mashhad University of Medical Sciences,Mashhad, Iran
AUTHOR
1- Elliott M.ST elevation myocardial intarction : management. In: Braunwald E, Libby p, Bonow R, Zipes DP, editors.
1
Braunwald's Heart disease. 8 th ed. Philadelphia: Elsevier Saunders; 2007.p. 1233-1251.
2
2- Barbash GI , white HD , modan M , Diaz R. Significance of smoking in patients receiving thrombolytic therapy for
3
acute mI. Circulation 1993; 87: 297-299.
4
3- Barbash GI, withe HD , modan M, Diaz R, Hampton JR, Heikkila J, et al. Acute mI in young – the role of smoking.
5
Eur Heart J 1995; 16: 295-296.
6
4- Kharash Lm , Gol’dkhammer EI. Thrombolytic therapy for acute myocardial infarction: circadian sensitivity. Ter
7
Arkh 1999; 71:13-17.
8
5- kharash LM , Gol’dkhammer EI, Abinader EC. The clinical aspects of thrombolytic therapy with streptokinuse in
9
mi. Ter Arkh 1996; 68:53-57.
10
6- kharash LM, Goldhammer EI , Abinader EI. Thrombolysis in myocardial infarction – out come optimization
11
methods . Klin Med (Mosk) 1998; 76: 25-29.
12
7- Mak KH , moliterno Dj , Granger CB , miller DP , white HD, Wilcox RG, et al . Influence of DM on Clinical out
13
come in the thrombolytic era of AMI. J Am coll cardiol 1997; 39:171 -179.
14
8- Chowdhury AR, Hossain M , Dey SR . A camparative study on the effect of streptokinase between diabetic and non
15
diabetic MI patients . Bangladesh J pharmacol 2008; 3:1-7.
16
9- Lee YY , Tee MH ,Zurkurnai Y , Than w , Sapawi M , suhairi I. Thrombolytic failure with streptokinase in acute
17
myocardial infarction using electrocardiogram criteria. Singa pore Med J 2008; 49:304-310.
18
10- White HD , Barbash GI , modan M, simes J, Diaz R, Hampton JR, et al. After correcting for worse baseline
19
characteristics , woman treated with thrombolytic therapy for AmI have the same mortality and morbidity as men
20
except for a higher incidence of hemorrhagic stroke. Circulation 1993; 88:2097-2103.
21
11- lew AS, Hod H , Cercek B, Shah pk , Ganz W. Mortality and morbidity rates of patients older and younger than 75
22
years with acute mi treated with IV Streptokinase . Am J cardiol 1987; 59:1-5.
23
ORIGINAL_ARTICLE
A Case Report of Primary Glomus Tumour of Stomach in a 59 Year Old Man
Introduction Primary gastric Glomus tumour is rare and much less frequent than gastrointestinal stromal tumors(GIST).a[S1]t least 150 of them have been reported in articles, but no one had been published in Iran. [ Case report Patient was a 59 years old man with the chief complains of sense of epigastric fullness after meal. Endosonography showed a hypoechoic mass in muscularis mucosa with 29×14 mm dimentions. p[S2]atient underwent wedge resection of gastric tumour. In microscopy, sheets and nodules of round to polyhedral uniform cells with bland round to oval nuclei in the background of branched hemangiopericytoma-like vascular stroma with hyalinised wall were seen. Smooth Muscle Actin, desmin, chromogranin and CD117 were determined immunohistochemicaly, the first marker was positive and the reminders were negative. Conclusion Primary gastric Glomus tumour is essentially a benign neoplasm[S3], in order to prevent unnecessary radical surgery, its differentiation from others malignant lesions is mandatory.
https://mjms.mums.ac.ir/article_5355_dc5138980f55f99f6b6190f46fdf440d.pdf
2011-06-22
120
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10.22038/mjms.2011.5355
Glomus tumour
Gastric
Glomangioma
Ahmad
Khosravi
khosravia@mums.ac.ir
1
Associate professor of Internal Medicine,Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Mehrdad
Katebi
2
Pathologist
AUTHOR
Hosein
Shabahang
3
Assistant professor of General Surgery,Mashhad University of Medical sciences, Mashhad, Iran
AUTHOR
Bahram
Memar
4
Assistant professor of Pahology, MashhadUniversity of Medical sciences, Mashhad, Iran
AUTHOR
Mitra
Ahadi
mitraa@mums.ac.ir
5
Resident of gastrointestinal and liver disease fellowship,Mashhad University of Medical Sciences, Mashhad, Iran
LEAD_AUTHOR
Elham
Mokhtari
6
Resident of gastrointestinal and liver disease fellowship,Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
1- Tsuneyoshi M, Enjoji M.Glomus tumor.A clinicopathologic and electron microscopic study.Cancer 1982; 50:1601-
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2- Enzinger FM, Goldblum JR. Perivascular tumors. In: Enziger FM, Weiss SW, editors. Soft tissue tumors 4th ed. St Louis,
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MD: mosby; 2001. p.985-1003.
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3- Miettinen M, Paal E, Lasota J, Sobin LH.Gastrointestinal glomus tumors: A clinicopathologic, immunohistochemical, and
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molecular genetic study of 32 cases. Am J Surg Pathol 2002; 26:301-311.
5
4- Batra R ,Mehta A, Rama Mohan P, Singh K. Glomus tumor of the stomach. Indian J Patho Microbiol 2009; 52:77-79.
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5- Vanwijnsberghe S, Rubay R, Descamps C, Verdebout JM, Navez B. A glomic tumour of the stomach treated by
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laparoscopy. Acta Chir Belg 2006; 106:613-615.
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6- Spangler H. [An angioneuromyoma (glomus tumor) of the stomach and other neurogenic tumors of gastrointestinal
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tract.]. Chirurg 1953; 24:181-184.
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7- Key S, Kallahn WP. Glomus tumours of the stomach. Cancer 1951;726-736 .
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12
Gastroenterology 2006; 40:717-720.
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9- Harig BM, Rosen Y, Dallemand S, Farman J. The radiology corner. Glomus tumor of the stomach. Am J
14
Gastroenterol 1975; 63:423-428.
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10- Yamada Y, Yokochi K, Itou O, Itou G, Tashiro Y, Ichikawa H, et al. A glomus tumor of the stomach associated
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with a lipoma. Gan No Rinsho Japan J Cancer Clin 1988; 34:2096-2101.
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11- Vinette-Leduc D, Yazdi HM. Fine-needle aspiration biopsy of a glomus tumor of the stomach. Diagn Cytopathol
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2001; 24:340-342.
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12- Stelzner S, Freitag M, Roitzsch E, Jacobasch L, Erk JU, Ludwig K. Glomus tumour of the stomach. A case report.
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Chirurg 2003; 74:65-68.
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13- Bray APJJ, Wong NACS, Narayan S. Cutaneous metastasis from gastric glomus tumour. Clin Exp Dermatol 2009;
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14- Tavusbay C, Gen H, Haciyanli M, ûzlem Sayin G ,Ekinci N. Glomus tumor of the stomach: A rare cause of upper
23
gastrointestinal bleeding. Ulu Travma Acil Cerrahi Derg 2009; 15:85-87.
24
15- Lee MM, Kwon YK, Lim SS. A case of glomus tumor of the stomach misdiagnosed for gastric polyp. Korean J
25
Med 2010;198:38,127-130.
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16- Haque S, Modlin IM, West AB. Multiple glomus tumors of the stomach with intravascular spread. Am J Surg
27
Pathol 1992;16:291-299.
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17- Urba czyk K,Stachura J, Papla B, Karcz D, Mat_éok M. Gastric solid glomus tumor and multiple
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glomangiomyomas of the large bowel with intravascular spread, multifocal perivascular proliferations and liver
30
involvement. Polish J Pathol 2007; 58:207-214.
31
18- Kanwar YS, Manaligod JR .Glomus tumor of the stomach. An ultrastructural study. Arch Pathol Lab Med 1975;
32
99:392-397.
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19- Calonje E, Fletcher C. Vascular tumors. In: Fletcher C, editor. Diagnostic histopathologic of tumors. 3th ed. Boston:
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churchil livingstone elsevier; 2007. p.70-72.
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20- Campbell F, lauers G, williams G. Tumors of esophagus and stomach. In: Fletcher C,editor.Diagnostic
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histopathologic of tumors. 3th ed. Boston: Churchil livingstone elsevier; 2007. p. 340-64.
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21- Gu M, Nguyen PT, Cao S, Lin F. Diagnosis of gastric glomus tumor by endoscopic ultrasound-guided fine needle
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aspiration biopsy: A case report with cytologic, histologic and immunohistochemical studies .Acta Cytolog 2002;
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46:560-566.
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22- Debol SM, Stanley MW, Mallery S, Sawinski E, Bardales RH. Glomus tumor of the stomach: Cytologic diagnosis
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by endoscopic ultrasound-guided fine-needle aspiration. Diag Cytopathol 2003; 28:316-321.
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23- Nakajima S, Nishiyama K, Hosoi H, Yamazaki Y, Akabane H. A case report of glomus tumor of the stomach.
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Gastroenterol Endoscopy 1996; 38:316-322.
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24- Almagro UA, Schulte WJ, Norback DH, Turcotte JK. Glomus tumor of the stomach. Histologic and ultrastructural
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