ORIGINAL_ARTICLE
Association of HTLV-I with Autoimmune Thyroiditis in Patients withMyelopathy/tropical Spastic Paraparesisand in HTLV-I Carriers
Introduction There are some reports about the association of autoimmune thyroid diseases with human T cell leukemia virus type I (HTLV-I) infection. The objective of this study was to estimate the seroprevalence rates of anti-thyroid antibodies in HTLV-I carriers and HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients in Mashhad, north east of Iran, to determine any association between HTLV-I infection and Hashimoto’s thyroiditis (HT). Materials and Methods A total of 46 HTLV-I infected patients (24 patients with HAM/TSP and 22 asymptomatic carriers) and 40 HTLV-I seronegative healthy individuals were screened for the presence of thyroid autoantibodies. The diagnosis of HT was based on the presence of positive thyroid autoantibodies (Anti thyroid peroxidase and/or Anti thyroglobulin) and at least one of two additional criteria (hypothyroidism and/or goiter). Analysis of data was done, using Fisher-Exact test by statistical software SPSS version 13.0. A P value below 0.05 was considered statistically significant. Results Positivity for thyroid autoantibodies was found in 14 (63.6%) of 22 asymptomatic carriers, 6 (25%) of 24 patients with HAM/TSP and 3 (7.5%) of 40 HTLV-I seronegative healthy individuals. HT found in 45.4% of asymptomatic carriers, 25% of HAM/TSP patients and 5% of seronegative healthy individuals. Conclusion This study demonstrates a high prevalence of HT in the HAM/TSP patients and the HTLV-I carriers in Mashhad. Our findings suggest an association between HTLV-I infection and HT in our region.
https://mjms.mums.ac.ir/article_5395_af6cb21f488adccf76ab1b63a7752115.pdf
2010-03-21
7
10
10.22038/mjms.2010.5395
HAM/TSP
Hashimoto’s Thyroiditis
HTLVI
Morteza
Taghavi
1
Assistant Professor of Endocrinology, Endocrine Research Center, Mashhad Medical University, Mashhad, Iran
LEAD_AUTHOR
Reza
Farid Houseni
rfaridh@gmail.com
2
Professor of Immunology, Ghaem Hospital, Mashhad Medical University, Mashhad, Iran
AUTHOR
Hosein
Ayatollahi
3
Assistant Professor of Pathology Department, Ghaem Hospital, Mashhad Medical University, Mashhad, Iran
AUTHOR
1- Gessain A. Epidemiology of HTLV-I and associated diseases. In: Hollsberg P, Hafler DA, eds. Human T-cell
1
lymphotropic virus type I. Chichester, UK: John Wiley Sons; 1996.p. 33–64.
2
2- Hinuma Y, Nagata K, Hanaoka M, Nakai M, Matsumoto T, Kinoshita KI, et al. Adult T-cell leukemia: antigen in an ATL
3
cell line and detection of antibodies to the antigen in human sera. Proc Natl Acad Sci USA 1981; 78:6476–6480.
4
3- Osame M, Usuku K, Izumo S, Ijichi N, Amitani H, Igata A, Matsumoto M, Tara M . HTLV-I associated
5
myelopathy, a new clinical entity. Lancet 1986; 1:1031–1032.
6
4- Gessain A, Barin F, Vernant JC, Gout O, Maurs L, Calender A. de The G Antibodies to human T-lymphotropic virus
7
type-I in patients with tropical spastic paraparesis. Lancet 1985; 2:407–410.
8
5- Mochizuki M, Yamaguchi K, Takatsuki K, Watanabe T, Mori S, Tajima K. HTLV-I and uveitis. Lancet 1992;
9
6- Nishioka K, Maruyama I, Sato K, Kitajima I, Nakajima Y, Osame M. Chronic inflammatory arthropathy associated
10
with HTLV-I. Lancet 1989; 1:441.
11
7- Sugimoto M, Nakashima H, Watanabe S, Uyama E, Tanaka F, Ando M, Araki S, Kawasaki T-lymphocyte alveolitis
12
in HTLV-I-associated myelopathy. Lancet S 1987; 2:1220.
13
8- Vernant JC, Buisson G, Magdeleine J, De Thore J, Jouannelle A, Neisson-Vernant C, et al. T-lymphocyte alveolitis,
14
tropical spastic paresis, and Sjögren syndrome. Lancet 1988; 1:177.
15
9- Taghavi M, Fatima S. Prevalence of HTLV-1 infection in type 2 diabetic patients in Mashhad, northeastern Iran. Br
16
J Diabetes Vasc Dis 2009; 9: 81.
17
10-Kawai H, Inui T, Kashiwagi S, Tsuchihashi T, Masuda K, Kondo A, et al. HTLV-I infection in patients with
18
autoimmune thyroiditis (Hashimoto’s thyroiditis). J Med Virol 1992; 38:138–141.
19
11-Yamaguchi K, Mochizuki M, Watanabe T, Yoshimura K, Shirao M, Araki S, et al. Human T lymphotropic virus
20
type 1 uveitis after Graves’ disease. Br J Ophthalmol 1994; 78:163–166.
21
12-Mizokami T, Okamura K, Kohno T, Sato K, Ikenoue H, Kuroda T, Inokuchi K, Fujishima M Human T-lymphotropic
22
virus type I-associated uveitis in patients with Graves’ disease treated with methylmercaptoimidazole. J Clin Endocrinol
23
Metab 1995; 80:1904–1907.
24
13-Mizokami T, Okamura K, Ikenoue H, Sato K, Kuroda T, Maeda Y, Fujishima M A high prevalence of human Tlymphotropic
25
virus type I carriers in patients with antithyroid antibodies. Thyroid 1994; 4:415–419.
26
14-Mine H, Kawai H, Yokoi K, Akaike M, Saito S High frequencies of human T-lymphotropic virus type I (HTLV-I)
27
infection and presence of HTLV-II proviral DNA in blood donors with anti-thyroid antibodies. J Mol Med 1996;
28
74:471–477.
29
15-Akamine H, Takasu N, Komiya I, Ishikawa K, Shinjyo T, Nakachi K, et al. Association of HTLV-I with
30
autoimmune thyroiditis in patients with adult T-cell leukaemia (ATL) and in HTLV-I carriers. Clin Endocrinol (Oxf.)
31
1996; 45:461–466.
32
16-Kawai H, Mitsui T, Yokoi K, Akaike M, Hirose K, Hizawa K, Saito S Evidence of HTLV-I in thyroid tissue in an
33
HTLV-I carrier with Hashimoto’s thyroiditis. J Mol Med 1996; 74:275–278.
34
17-Kubonishi I, Kubota T, Sawada T, Tanaka Y, Machida H, Yoshida O, et al. An HTLV-I carrier with Graves’ disease
35
followed by uveitis: isolation of HTLV-I from thyroid tissue. Int J Hematol 1997; 66:233–237.
36
18-Abbaszadegan MR, Gholamin M, Tabatabaei A, Houshmand M. Prevalence of Human T-Lymphotropic Virus Type
37
1 among Blood Donors from Mashhad, Iran. J Clin Microbiol 2003; 41: 2593-2595.
38
19- Osame M. Review of WHO Kagoshima meeting and diagnostic guidelines for HAM/TSP. In: Blattner WA, ed.
39
Human retrovirology: HTLV. New York: Raven Press; 1990.p.191–197.
40
20-Werner J, Gelderblom H. Isolation of foamy virus from patients with De Qurvain thyroiditis. Lancet 1979; 2:258–259.
41
21- Ito M, Tanimoto M, Kamura H, Yoneda M, Morishima Y, Yamauchi K, et al. Association of HLA antigen and
42
restriction fragment length polymorphism of T cell receptor ß-chain gene with Graves’ disease and Hashimoto’s
43
thyroiditis. J Clin Endocrinol Metab 1989; 69:100–104.
44
22- Barbesino G, Tomer Y, Concepcion E, Davies TF, Greenberg DA. The international consortium for the genetics of
45
autoimmune thyroid disease linkage analysis of candidate genes in autoimmune thyroid disease: 1. Selected
46
immunoregulatory genes. J Clin Endocrinol Metab 1998; 83:1580–1584.
47
23-Tomoyose T, Komiya I, Takara M, Yabiku K, Kinjo Y, Shimajiri Y, et al. Cytotoxic T-lymphocyte antigen-4 gene
48
polymorphisms and human T-cell lymphotrophic virus-1 infection: their associations with Hashimoto’s thyroiditis in
49
Japanese patients. Thyroid 2002; 12:673–677.
50
24-Nagai M, Usuku K, Matsumoto W, Kodama D, Takenouchi N, Moritoyo T, et al. Analysis of HTLV-I proviral load
51
in 202 HAM/TSP patients and 243 asymptomatic HTLV-I carriers: high proviral load strongly predisposes to
52
HAM/TSP. J Neurovirol 1998; 4:586–593.
53
25-Matsuda T, Tomita M, Uchihara JN, Okudaira T, Ohshiro K, Tomoyose T, et al. Human T cell leukemia virus type
54
I-infected patients with hashimoto’s thyroiditis and Graves’ disease. J Clini Endocrinol Metab 2005; 10:5704-5710.
55
26-Yakova M, Lezin A, Dantin F, Lagathu G, Olindo S, Jean-Baptiste G, et al. Increased proviral load in HTLV-1-
56
infected patients with rheumatoid arthritis or connective tissue disease. Retrovirology 2005; 2:4–12.
57
ORIGINAL_ARTICLE
A Study of Relation between Plasma Level of Insulin-like Growth Factor-1 (IGF-1) and Severity of Coronary Artery Disease
Introduction Atherosclerosis and its related diseases are major causes of mortality in many countries. Our knowledge of its background is of much importance. In recent years, researches have been preformed on relation between atherosclerosis and IGF-I plasma levels and different results obtained. We decided to do this research, as few studies have been done in this field in our country. Materials and Methods Altogether One hundred and seven patients who were candidates for the coronary angiography were chosen for study. Blood samples were taken for measuring IGF-I, FBS, triglyceride, total cholesterol, LDL and HDL in plasma. Blood pressures of patients were recorded, and their BMIs accounted. It was also written in questionnaire if they had history of cigarette smoking. Results IGF-I plasma levels increased in relation to intensity of coronary artery stenosis; correlation coefficient between stenoses and IGF-I plasma levels was as follows: R= 0.204 p= 0.04. This suggested significant and meaningful relation between these variables. IGF-I plasma levels also showed mild increase in relation to number of diseased coronary arteries. By using the analysis of spierman correlation coefficient, Rho= 0.189 and p= 0.058 were accounted. Conclusion We concluded that IGF-I plasma levels were in direct and meaningful relation to stenosis values of coronary arteries, and in mild relation to number of diseased coronary arteries. These findings can explain the role of IGF-1 in process of atherosclerosis.
https://mjms.mums.ac.ir/article_5396_40d9b284e9743f078da88c4b766d07e9.pdf
2010-03-21
11
15
10.22038/mjms.2010.5396
Atherosclerosis
Coronary artery stenosis
Insulin- like growth factor- 1 (IGF-1)
Gholamreza
Yousefzadeh
1
Assistant Professorof Cardiology, Shafa Hospital, Kerman University of Medical Sciences, Kerman, Iran
AUTHOR
Mohammad
Maasoumi
2
Associate Professor of Cardiology, Shafa Hospital, Kerman University of Medical Sciences, Kerman, Iran
AUTHOR
Ali
Emadzadeh
emadzadea@mums.ac.ir
3
Resident of Internal Medicine of Cardiology, Shafa Hospital, Kerman University of Medical Sciences, Kerman, Iran
LEAD_AUTHOR
Armita
Shahesmaeeli
4
General Practitioner of Afzalipour Hospital, KermanUniversity of Medical Sciences, Kerman, Iran
AUTHOR
1- Clemmous David R. Physiology of Insulin-like Growth factor I. In uptodate 16.3. Available at:
1
http://www.uptodate.com.
2
2- Plengpanich W, Mangkala J, Buranasukajorn P, Boonruang K, Sunthornyothin S, Suwanwalaikorn S, et al.
3
Normal Refrence Range of serum insulin – like Growth factor ( IGF) –I in healthy thai Adults. J med Assoc Thai
4
2008; 91:1681-1684.
5
3- Perticone F, Sciacqua A, Perticone M, Laino I, Miceli S, Care` I, et al. Low-plasma insulin-like growth factor -1
6
levels are associated with impaired endothelinum-dependent vasodilatation in a cohort of untreated,hypertensive
7
Caucasian subjects. J Clin Endocrinol Metab 2008; 93:2806-2810. Epub 2008 Apr 22
8
4- Brevetti G, Colao A, Schiano V, Pivonello R, Laurenzano E, Di Somma C, et al. IGF system and peripheral
9
arterial disease:relationship with disease severity and inflammatory status of the affected limb. Clin
10
Endocrinol(Oxf) 2008; 69:894-900 .Epub 2008 Apr 10.
11
5- Kawachi S, Takeda N, Sasaki A, Kokubo Y, Takami K, Sarui H, et al. Circulating Insulin-like growth factor-1
12
and Insulin-like growth factor binding protein-3 are associated with early carotid atherosclerosis. Arterioscler
13
Thromb Vasc Biol 2005; 25:617-621. Epub 2004 Dec 29.
14
6- Martin RM, Gunnell D, Whitley E, Nicolaides A, Griffin M, Georgiou N, et al. Association of insuline-like
15
growth factor(IGF)-1, IGF-2, IGF binding protein(IGFBP)-2 and IGFBP-3 with ultrasound measures of
16
atherosclerosis and plaque stability in an older adult population. J Clin Endocrinol Metab 2008; 93:1331-1338.
17
Epub 2008 Jan 22.
18
7- Lawlor DA, Ebrahim S, Smith GD, Cherry L, Watt P, Sattar N. The association of insulin-like growth factor
19
1(IGF-1) with incident coronary heart disease in women:Findings from the prospective British Women`s Heart and
20
Health Study. Atherosclerosis 2008; 201:198-204. Epub ahead of print.
21
8- Laura A. ColangeloI, Kiang Liu1, Susan M. Gapstur. Insulin-like growth factor-1, Insulin-like growth factor
22
binding protein-3, and cardiovascular disease risk factors in young black men and white men. Am J Epidemiol
23
2004; 160:750–757.
24
9- Abbas A, Grant PJ, Kearney MT. Role of IGF-1 in glucose regulation and cardiovascular disease. Expert Rev
25
Cardiovascular Ther 2008; 6:1135-1149.
26
10- Ostadrahimi A, Moradi T, Zarghami N, Shoja MM. Correlates of serum leptin and insulin- like growth factor-1
27
concentrations in normal weight and overweight/obese Iranian woman. J Womens Health (Larchmt) 2008; 17:1389-1397.
28
11- Sukhanov S, Higashi Y, Shai SY, Vaughn C, Mohler J, Li Y, Song YH, et al. IGF-1 reduces inflammatoy
29
responses, suppresses oxidative stress, and decreases Atherosclerosis progression in Apo E deficient mice.
30
Arteioscler throm b Vasc Biol 2007; 27:2684- 2690.
31
12- Ruiz Torres A. The role of Insulin – Like growth factor 1 and insulin in aging and atherosclerosis. Novartis
32
Founal symp 2002; 242:143-153;discussion 153-60.
33
13- Ukkola o, Poykko S, Paivansalo M, Kesaniemi YA. Interactions between ghrelin, leptin and IGF –I affect
34
metabolic syndrome and early Atherosclerosis .Ann med 2008; 40: 465-473.
35
14- Saleem T, Mohammad KH, Abdel-Fattah MM, Abbasi AH. Association of glycosylated haemoglobin level
36
and diabetes mellitus duration with the severity of coronary artery disease. Diab Vasc Dis Res 2008; 5:184-189.
37
15- Akanji AO, Suresh CG, Al-Radwan R, Fatania HR. Insulin-like growth factor (IGF)-I, IGF-II and IGFbinding
38
protein (IGFBP)-3 levels in Arab subjects with coronary heart disease. Scand J Clin Lab Invest 2007;
39
16- Juul A, Scheike T, Davidsen M, Gyllenborg J, Jørgensen T. Low serum insulin-like growth factor I is
40
associated with increased risk of ischemic heart disease: a population-based case-control study. Circulation 2002;
41
106: 939–944.
42
17- Kaplan RC, McGinn AP, Pollak MN, Kuller LH, Strickler HD, Rohan TE, et al. Association of total insulinlike
43
growth factor-I, insulin-like growth factor binding protein-1 (IGFBP-1), and IGFBP-3 levels with incident
44
coronary events and ischemic stroke. J Clin Endocrinol Metab 2007; 92:1319-1325.
45
18- Unden AL, Elofsson S, Knox S, Lewitt MS, Brismar K. IGF-I in a normal population: relation to psychosocial
46
factors. Clin Endocrinol (Oxf) 2002; 57:793-803.
47
19- Sierra – Johnson J, Romero-Corral A, Somers VK, Lopez-Jimenez F, Mälarstig A, Brismar K, Hamsten A, et al. IGF
48
–I / IGFBP-3 ratio: a mechanistic insight into the metabolic syndrome. Clin Sci (Lond) 2009; 116:507-512.
49
ORIGINAL_ARTICLE
Mycotic Keratitis, A Study on Etiologic Agents, Predisposing Factors and the Result of Treatment among 44 Patients
Introduction Mycotic Keratitis is a suppurative, usually ulcerative, and sight threatening infection of cornea that sometimes leads to loss of vision. The peak of incidence is observed in the tropical and subtropical regions. To investigate the etiological agent, predisposing factors and treatment follow up of mycotic keratitis; this study was undertaken over a period of 2 years in Mashhad. Materials and Methods In this prospective, cross sectional study, among 466 individuals suffering from keratitis,65 patients , highly suspected to mycotic keratitis were examined by direct fresh smear (KOH 10%) and culture in Mycology Media. The results were analyzed by SPSS method. Results Among 65 clinically suspected individuals, the results of direct smear and culture of 44 patients were positive. of patients, 21 were male (47.1%) and 24 were female (52.3%). The patients were between 8 to 84 years old. More than 40% of them were farmers. Trauma was the most common predisposing factor in more than 47% of cases due to vegetable materials. Molds and Yeasts were isolated from 86.4% and 13.6% of the samples respectively. Fusarium spp. were the most frequent isolates (44.4%).Others included Aspergillus spp. (21.8%), Acremonium spp. (8.3%), Penicillium spp. (5.6%) and Candida albicans (13.9%). Tearing and redness were the most common symptoms observed (93.2%). Amphotricin B was used in patients with Aspergillus and Candida Keratitis, but for Fusarium and other molds keratitis, Natamycin was used for 6 to 12 weeks. In one patient with Fusarium Keratitis, medical therapy was failed and therapeutic penetrating keratoplasty was performed. Six months follow up showed that prognosis was good in all of the patients. Conclusion In relation to the last decade, the incidence of Mycotic Keratitis is increased in Mashhad. Keratitis due to the molds is more prevalent than yeast keratitis. Entrance of foreign body (Plant particles) is the most common predisposing factor. However, it needs long term therapy but the prognosis is good.
https://mjms.mums.ac.ir/article_5403_4a135f5f8c0bad13d10fffaccf16eba7.pdf
2010-03-21
16
25
10.22038/mjms.2010.5403
Aspergillus Keratitis
Candidial keratitis
Fungal Keratitis
Fusarium Keratitis
Mycotic Keratitis
Sara
Fata
1
eneral Practitioner, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Akbar
Derakhshan
derakhshana@mums.ac.ir
2
گــروه چــشم بیمارســتان خــاتم الانبیــاء، دانشگاه علوم پرشکی مشهد، ایران
AUTHOR
Ali Akbar
Bolourian
3
دانشکده پزشکی دکتر شاهین فر، دانشگاه آزاد اسلامی مشهد، ایران
AUTHOR
Mohammad reza
Sedaghat
4
گــروه چــشم بیمارســتان خــاتم الانبیــاء، دانشگاه علوم پرشکی مشهد، ایران
AUTHOR
Hamid
Khakhshour
5
گــروه چــشم بیمارســتان خــاتم الانبیــاء، دانشگاه علوم پرشکی مشهد، ایران
AUTHOR
Monavar
Afzalaghee
6
حــوزه معاونــت پژوهــشی، دانــشگاه علــوم پزشکی، مشهد، ایران
AUTHOR
Mojtaba
Meshkat
7
دانشکده پزشکی دکتر شاهین فر، دانشگاه آزاد اسلامی مشهد، ایران
AUTHOR
Mohammadjavad
Najafzadeh
8
گــروه انگــل شناســی وقــارچ شناســی، بیمارستان امام رضـا- دانـشگاه علـوم پزشـکی، مشهد، ایران
AUTHOR
Abdolmagid
Fata
fata@mums.ac.ir
9
گــروه انگــل شناســی وقــارچ شناســی، بیمارستان امام رضـا- دانـشگاه علـوم پزشـکی، مشهد، ایران
LEAD_AUTHOR
1- Shokoohi T. Laboratory study of 3 cases of mycotic keratitis members. J Guilan Univ Med Sci 1999; 8:89-95.
1
2- Barry MA, Pendarvis J, Rosenberg J, Chen S, Mshar P, Leguen F, et al. Centers for disease control and prevention
2
(CDC) . Fusarium keratitis – Multiple states, 2006; 55:400-401.
3
3- Rumpa saha,Shukla Das. Mycological profile of infectious keratitis from Dehli. Indian J Med Res 2006; 123:159-164.
4
4- Bharathi M Jayahar, Ramakrishnan R, Vasu S, Meenakshi R, Palaniappan R. Epidemiological characteristics and
5
laboratory diagnosis of fungal keratitis- A three-years study. Indian J Ophthalmol 2003; 51:315-321.
6
5- Agarwal pankaj K, Roy Pranatosh, Das Amitava, Banerjee Anita, Maity PraSanta K , Banerjee Asit R. Efficacy of
7
topical and Systemic itraconazole as a broad – Spectrum antifungal agent in mycotic corneal ulcer. A Preliminary
8
Study. Indian J Ophthalmol 2001; 46:173-179.
9
6- Berenji F, Elahi R, Fata A, Khakshoor H, Derakhshan A. Mycotic keratitis among patients referred to mycology
10
labratory, Emam Reza hospital. J Med School 1982-2001; 45:51-56.
11
7- Fata A, Derakhshan A, Kouhian H. First report of mycotic kerititis due to fusarium in Khorasan province and
12
successful penetrating keratoplasty. Med J Mashhad Univ Med Sci 2001; 44:125-129.
13
8- Yanoff M, Duker JS. Ophtalmology. 2nded. Spain: Mosby; 2003.vol 1.p.482-485.
14
9- Riordan P, Eva J, Whitcher P. Vaughan & Asbury’s. General Ophtalmology. 6nd
15
ed .New York: McGraw-hill;
16
2004.p.7-9, 50,129-130,135.
17
10- Chander J, Sharma A. Prevelance of fungal corneal ulcer in Northern India. Infection 1994; 22: 267-269.
18
11- Shenoy R, Shenoy UA, Al mahrooqui ZH. Keratomycosis due to Trichophyton mentagrophytes. Mycoses 2003;
19
46:157-158.
20
12- Doczi I, Gyetvai T, Kredics L, Nagy E.Involvement of fusarium SPP. in fungal keratitis. Clin Microbiol Infect
21
2004; 10:773-776.
22
13- Thomas PA. Fungal infections of the cornea. Eye 2003; 17:852-862.
23
14- Ritterbamd DC, Seedor JA, Shah MK, Koplin RS, McCormick SA.Fungal keratitis at the new york eye and ear
24
infirmary. Cornea 2006; 25:264-267.
25
15- Deshpande SD, Koppikar GV. A study of mycotic keratitis in Mumbai. Indian J pathol Microbial 1999; 42:81-87.
26
16- Kumari N, Xess A, Shahi SK.A Study of keratomycosis: our experience. Indian J Pathol Microbiol 2002; 45:299.
27
17- Panda A, Sharma N, Das G, Kumar N, Satpathy G. Mycotic keratitis in children: epidemiologic and microbiologic
28
evaluation. Cornea 1997; 16:295-299.
29
18- Usui T, Misawa Y, Honda N, Tomidokoro A, Yamagami S, Amano S. Nontraumatic keratomycosis
30
caused by Alternaria in a glaucoma Patient. lnt ophtalmol 2008. Available at: http://www.
31
Springerlink.com/content/h780762n857363t3. Accessed 2008 Sep 17.
32
19- Mendicute J, Orbegozo J, Ruiz M, Saiz A, Eder F, Aramberri J. Keratomycosis after cataraet surgery. J Cataract
33
Refract surg 2000; 26:1660-1666.
34
20- Xie L, Dong X, Shi w.Treatment of fungal keratitis by Peneteration keratoplasty. Br J ophthalmol 2001; 85:1070-1074.
35
21- D’hondt K,Parys-VAN,Ginderdeuren R,Foets B.Fungal keratitis Cauaed by Pseudallescheriaboydii (scedosporium
36
apiospermum).Bull Soc Belge Ophtalmol 2000;53-56.
37
22- Le Liboux MJ, Ibara SA, Quinio D, Moalic E. Fungal keratitis in a daily disposable soft contact lens wearer. J Fr
38
Ophtalmol 2004; 27:401-403.
39
23- Choi DM, Gold Stein MH, Salierno A, Driebe WT. Fungal keratitis in a daily disposale soft contact lens wearer.
40
CLAO J 2001; 27:111-112.
41
24- Moriyama AS, Hofling- Lima AL.Contact lens-associated microbial keratitis.Arq Bras Oftalmol 2008; 11:32-36.
42
25- Javadi MA,Hemati R,Mohammadi MM,Sajjadi SH.Causes of fungal keratitis and its management review of 11
43
cases from Labbafi Nejad Medical center. J Iran Soci Ophthalmol 1991; 3:33-16.
44
26- Zahra LV, Mallia D, Hardie JG, Bezzine A, Fenech T. Case report keratomycosis due to alternaria alternate in a
45
diabetic patient. Mycoses 2002; 45:512-514.
46
27- Parentin F, Liberali T, Perissutti P. Polymicrobial keratomycosis in a three years old child. Ocul Immunol Inflamm
47
2006; 14:129-131.
48
28- Tixier J, Bourcier T, Borderie V, Laroehe L. Infectous keratitis after penetrating keratoplasty. J Fr ophtalmol 2001;
49
24:597-602.
50
29- Mselle J. Use of topical clotrimazale in human keratomycosis. Ophthalmologica 2001; 215:357-360.
51
30- Lee SJ, Lee JJ, Kim SD. Topical and oral voriconazole in the treatment of fungal keratitis. Korea J Ophthalmol
52
2009; 23:46-48.
53
31- Saure A, Abry F, Lhermitte B, Candolfi E, Speeq-schatz C, Bourcier T. Purulent corneal melting secondary to multidrugresistant
54
Fusarium oxyporum aggrativated by topical corticosteroid therapy. J Fr Ophtalmol 2008; 31:534-535.
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ORIGINAL_ARTICLE
A Study of the Complaint of Patients Coming to the Emergency Ward of Khatam-ol-Anbia Eye Hospital Mashhad
"Center Research Ophthalmology of Mashhad University of Medical sciences"
Introduction Ocular emergency is one of the most common problems in the Emergency Department (ED), but a general survey of ocular emergencies has rarely been reported in the literature. This study reviews cases of ocular emergencies presented to the ED of Khatam Hospital (Mashhad) over a 6-months period. Materials and Methods A retrospective analysis was done on patients who presented with eye complaints to the ED of Khatam Hospital-Mashhad between March 2007 and August 2007. Ocular diagnoses and hospitalizations due to ocular emergencies in addition to their associated variables were collected and assessed separately. Results 28,312 patients presented to the ED during the period with eye complaints. The most frequent diagnoses in newly presented patients were grouped as trauma (61%) and inflammatory disorders (22%). A male to female ratio of about 2.5:1 was assessed. Both genders had the peak age in the third decade. There was a trend toward increased numbers in late spring and early summer. There were a total of 431 cases of hospitalization (1.5% of all presented patients) most of them due to traumatic consequences notably globe rupture (38% of all hospitalizations). Ocular occupational casualties estimated to be responsible for 43% of all traumatic injuries occurred between 20-59 years of age. Conclusion Young males were found to run a higher risk of ocular accidents, especially at work. Individuals under 10 years of age estimated to be particularly at risk for severe ocular traumas e.g. eye penetration. Taking more care of these two specially at risk groups and directing protectional educations and preprations towards their work and play could be suggested.
https://mjms.mums.ac.ir/article_5404_a771d06a7a6ddac6e9136402e8a19fc4.pdf
2010-03-21
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10.22038/mjms.2010.5404
Foreign body
Ocular infection
Ocular trauma
Hamid
Gharaee
1
Assistant Professor of Ophthalmology, Khatamol-Anbia Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
LEAD_AUTHOR
Mirnaghi
Mousavi
mousavimn@mums.ac.ir
2
Associate Professor of Ophthalmology, Khatamol-Anbia Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Majid
Rouhbakhshzaeri
3
Ophthalmologist
AUTHOR
Abozar
Ghaem Pnah
4
General Practitioner
AUTHOR
1- Edwards RS. Ophthalmic emergencies in a district general hospital casualty department. Br J Ophthalmol 1987;
1
71:938-942.
2
2- Kaimbo WK, Spileers W, Missotten L. Ocular emergencies in Kinshasa (Democratic Republic of Congo). Bull Soc
3
Belge Ophtalmol 2002; 49-53.
4
3- Tsai CC, Kau HC, Kao SC, Liu JH. A review of ocular emergencies in a Taiwanese medical center. Zhonghua Yi
5
Xue Za Zhi (Taipei) 1998; 61:414-420.
6
4- MacCumber MW, Kerrison JB, Pieramici DJ, Goldberg MF. Emergent clinical senarios: differential diagnosis and
7
recommended guidelines for timing of specialized evaluation. In: MacCumber MW, editor. Management of ocular
8
injuries and emergencies. Philadelphia: Lippincott-Raven; 1998. p. 1-8.
9
5- Congdon NG, Schein OD. The epidemiology of ocular trauma: a preventable ocular emergency. In: MacCumber
10
MW, editor. Management of ocular injuries and emergencies. Philadelphia: Lippincott-Raven; 1998. p. 9-26.
11
6- Kerrison JB, Iwamoto MA, Merbs SL, Iliff NT. Orbital trauma. In: MacCumber MW, editor. Management of ocular
12
injuries and emergencies. Philadelphia: Lippincott-Raven; 1998. p. 107-15.
13
7- Edwards MG, Pieramici DJ, Fekrat S, Azar DT, Stark WJ, MacCumber MW. Corneoscleral lacerations and ruptures.
14
In: MacCumber MW, editor. Management of ocular injuries and emergencies. Philadelphia: Lippincott-Raven; 1998. p.
15
8- Raja SC, Goldberg MF. Injuries of anterior segment. In: MacCumber MW, editor. Management of ocular injuries
16
and emergencies. Philadelphia: Lippincott-Raven; 1998. p. 227-32.
17
9- Humayun MU, Santos A, Juan JR. Management of intraocular foreign bodies. In: MacCumber MW, editor.
18
Management of ocular injuries and emergencies. Philadelphia: Lippincott-Raven; 1998. p. 309-318.
19
10- Asgari M. Evaluation of cases of ocular trauma requiring admission in ophthalmology department of Gaem
20
Hospital. Medical doctorate thesis, MUMS, 1377.
21
11- Ganai Omid. Evaluation of admitted patients due to ocular trauma and their management between 1378-1380.
22
Medical doctorate thesis, MUMS, 1381.
23
12- Bohrani Maryam. Evaluation of corneal foreign bodies, causes and symptoms in 100 patients conferred to khatamal-anbia
24
eye hospital. Medical doctorate thesis, MUMS, 1382.
25
13- Kalani Toktam. Epidemiologic and demographic evaluation of chemical burn cases reffering to khatam-al-anbia
26
hospital in 1383. Medical doctorate thesis, MUMS, 1384.
27
14- Sadda SR, Iliff NT .Infections of the lacrimal system, eyelids and orbit .In: Mac Cumber MW,editor. Management
28
of ocular injuries and mergencies. Phladelphia:Lippincott-Raven;1998.p.117-134.
29
15- Rivellese MJ, Ma Cumber MW, Schachat AP. Sudden nontraumatic visual loss and visual disturbances. In: Mac
30
Cumber MW, editor. Management of ocular injuries and emergencies. Philadelphia: Lippincott-Raven; 1998.p.333-349.
31
16- Mansuri M. Evaluation of patients conferring to emergency department of Farabi eye hospital. Iran ophthalmol J
32
1998; 2: 53-56.
33
17- Riazi Esfahani M. Evaluation of work related ocular trauma in Yazd Rahahan Hospital (1997-88). Bina J
34
ophthalmol 1999.
35
18- Shoj M. Evaluation of work related eye injuries in Farabi eye hospital emergency department (1998). Iran J
36
ophthalmol 2000; 1, 2: 48-57.
37
19- Nikeghbali A.Traumatic scleral laceration and prognostic factors. Iran J Ophthalmol 1996.
38
ORIGINAL_ARTICLE
Telephone Follow-up Following Office in Post Operations Pediatric Patients that Have out-Patients’ Surgeries
Introduction In recent years, we have noticed that centres for clinical treatments have facilitates for surgery patients. These facilitates can help patients and theirs families to take recovery and safety in using healthy professional cares. Telephone follow-up following office in out-patients is usual observation for their surgery. The aim was evaluation of security and safety of this method of follow-up and use of this method for the post operation pediatric patients who visit the clinic. Materials and Methods The patients followed up for 6 months after the surgery by telephone. Special form completed for each patient. These forms were clinical records and follow-up. Results We evaluated 120 out-patients. In 108 cases, we had good communications with their parents. Twelve cases didn’t have an communication (neither telephone nor through post operation visit to clinic). A total of 10 cases came to clinic for the post operation visit without any calling them, because they thought that they were needed. Although, we advised 8 cases to visit the clinic. Conclusion Follow-up through telephone with organized protocol is a current method of follow-up in elective surgical patients. It is not only safe but also it is less expensive and saves time for patients, parents and physicians.
https://mjms.mums.ac.ir/article_5405_a605a4ba0064e35eb99ba2fd3d64024d.pdf
2010-03-21
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10.22038/mjms.2010.5405
Follow-up
Pediatrics out patient surgery
Telephone
Marjan
Joodi
1
Assistant professor of Pediatric Surgery, Dr sheikh Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
LEAD_AUTHOR
Mehran
Hyradfar
2
Associated professor of Pediatric Surgery, Dr sheikh Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Mona
Jodi
3
General practitioner, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Haleh
Bromand
4
Master of Nursing, Dr Sheikh Hospital, MashhadUniversity of Medical Sciences, Mashhad, Iran
AUTHOR
1- Melzer SM, Reuben MS. American Academy of Pediatrics section on telephone care and committee on child health
1
financing,payment for telephone care. Pediatrics 2006; 118:1768-1773.
2
2- Wasson J, Gaudette C, Whaley F, Sauvigne A, Baribeau P, Welch HG. Telephone care as a substitute for routine
3
clinic follow-up. J Am Med Assoc 2000: 267:1788-1793.
4
3- Rao JN. Follow-up by telephone. Br Med J 1994: 309:1527-1528.
5
4- Mason C. Non-attendance at out-patient clinics. J Adv Nur 1999; 17:554-560.
6
5- Brada M, James ND. Phone clinic provides excellent support. Br Med J 1995; 310:738.
7
6- Pal B. Following up outpatients by telephone:apilot study. Br Med J 1998; 316:1674-1650.
8
7- Stephen Jeffery, Stergios K Doumouchtsis, Michelle Fynes. Patient satisfaction with nurse-led telephone follow-up
9
in women with lower urinary tract symptoms. J Telemed Telecare 2007; 13:374-376.
10
8- Fallaize RC, Tinline-Purvis C, Dixon AR, Pullyblank AM. Telephone ollow-up following office anorectal surgery.
11
Ann R Coll Surg Engl 2008; 90:464-466.
12
ORIGINAL_ARTICLE
The Role of Early Upper Gastrointestinal Endoscopy (less than 24 hours and after) in the Management of Corrosive Ingestion in Adults
"Liver and Gastrointestinal Diseases Research Center"
Introduction Upper gastrointestinal (UGI) endoscopy is the most reliable modality for evaluating patients with caustic injury of GI tract; however there is an ongoing debate on its optimal timing. Materials and Methods 100 adult patients with definite diagnosis of injury due to corrosive ingestion on direct laryngoscopy were evaluated in Tabriz Emam Khomeini Hospital during a 15-month period. The patients with signs and symptoms indicating a serious internal injury were operated immediately. In other patients, endoscopy was employed and according to timing, patients categorized in two groups; early (24 h). Inhospital condition of the two groups was compared. Results 62 females and 38 males (25.51±9.25 y/o) were recruited. Alkaline materials were used in majority of cases (83%). Eight percent of the patients were operated immediately. Early endoscopy was employed in 37% of patients and 55% underwent late endoscopy. Endoscopy results were normal in 11%, grade I in 36%, grade II in 22%, grade III in 11% and grade IV lesion in 12% of the patients. There was no significant difference between the two groups regarding the need of operation, gap between admission and operation, need of ICU admit and its duration and inhospital morbidity and mortality. However, operation gap and ICU admit were apparently better in early endoscopy group and morbidity was lower in late endoscopy group. Conclusion Early and late endoscopy did not significantly affect inhospital condition of adult patients with corrosive ingestion. However, early endoscopy was apparently along with better results.
https://mjms.mums.ac.ir/article_5406_9972549e046ee8010dcb35d044195bcf.pdf
2010-03-21
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10.22038/mjms.2010.5406
adults
Caustic Injury
Upper gastrointestinal endoscopy
Farzad
Kakaee
1
Assistant Professor of General Surgery, Tabriz University of Medical Sciences,Tabriz, Iran
AUTHOR
Mohammad Housein
Soumi
2
Associate Professor of Internal, TabrizUniversity of Medical Sciences,Tabriz, Iran
AUTHOR
Behnam
Sanei
3
Assistant Professor of General Surgery, Tabriz University of Medical Sciences,Tabriz, Iran
LEAD_AUTHOR
Seyed Housein
Montazer
4
Resident, TabrizUniversity of Medical Sciences,Tabriz, Iran
AUTHOR
1- Poley JW, Steyerberg EW, Kuipers EJ, Dees J, Hartmans R, Tilanus HW, et al. Ingestion of acid and alkaline agents:
1
outcome and prognostic value of early upper endoscopy.Gastrointest Endosc 2004; 60:372-327.
2
2- Satar S, Topal M, Kozaci N. Management of caustic substances by adults. Am J Ther 2004; 11:258-261.
3
3- Ramasamy K, Gumaste VV. Corrosive ingestion in adults. J Clin Gastroentrol 2003; 37: 119-124.
4
4- Arevalo-Silva C, Eliashar R, Wohlgelernter J, Elidan J, Gross M. Ingestion of caustic substanceL a 15 year
5
exprience. Laryngoscope 2006; 116:1422-1426.
6
5- Litovitz TL, Swartz WK, White S.Annual report of the American association of poison control centers. Am J Emerg
7
Med 2000; 19:337–395.
8
6- Gumaste VV, Dave PB. (1992). Ingestion of corrosive substances by adults. Am J Gastroenterol 1992; 87:1–5.
9
7- Moore WR. Caustic Ingestions. Clin Pediatr 1986; 25:192.
10
8- Castell DO, Richter J.The Esophagus.21sted. Philadelphia: Lippincott Williams and Wilkins;1999.p.557–564.
11
9- Cox AJ, Eisenbeis JF. Ingestion of Caustic hair relaxer: Is endoscopy necessary? Laryngoscope 1997; 107:897–902.
12
10- Zargar SA, Kochhar R, Nagar B. Ingestion of corrosive acid. Gastroenterology 1989; 97: 702–707.
13
11- Zargar SA, Kuchhar R, Mehta S. The role of fibroptic endoscopy in the management of corrosive ingestion and modified
14
endoscopic classification of burns. Gastrointest Endosc 1991; 37:165–169.
15
12- Mutaf O, Genc A, Herek O. Gastroesophageal reflux: A determinant in the outcome of caustic esophageal burns. J
16
Pediatr Surg 1996; 31:1494–1495.
17
13- Bautista A, Varela R, Villanueva A. Motor function of the esophagus after caustic burn. Eur J Pediatr Surg 1996;
18
6:204–207.
19
14- Nicosia JF, Thornton JP, Folk FA. Surgical management of corrosive gastric injuries. Ann Surg 1994; 180:139–143.
20
15- Dilwari JB, Sing S, Rao PN.Corrosive acid ingestion in man: A clinical and endoscopic study. Gut 1994; 25:183–187.
21
16- Hawkins DB, Demeter MJ, Barnett TE. Caustic ingestion: controversies in management. A review of 214 cases.
22
Laryngoscope 1990; 90:98–109.
23
17- McAuley CE, Steel DL, Webster MW. Late sequelae of gastric acid injury. Am J Surg 1995; 149:412–415.
24
18- Gore R, Levine M, Laufer I. Textbook of Gastrointestinal Radiology.4thed. Philadelphia: WB Saunders; 2000.p.2–14.
25
19- Harley EH, Collins MD. Liquid household bleach ingestion in children. Laryngoscope 1997; 107:122–125.
26
20- Ahsan S, Haupert M.Absence of esophageal injury in pediatric patients after hair relaxer ingestion. Arch
27
Otolaryngol Head Neck Surg 1999; 125:953–955.
28
21- Cheng HT, Cheng CL, Lin CH, Tang JH, Chu YY, Liu NJ, et al. Caustic ingestion in adults: the role of endoscopic
29
classification in predicting outcome.BMC Gastroenterol 2008; 8:31.
30
22- Havanond C. Clinical features of corrosive ingestion.J Med Assoc Thai 2003; 86:918-924.
31
23- Christesen HB. Ingestion of caustic agents. Epidemiology, pathogenesis, course, complications and prognosis.
32
Ugeskr Laeger 1993; 155:2379-2382.
33
24- Gupta SK, Croffie JM, Fitzgerald JF. Is esophagogastroduodenoscopy necessary in all caustic ingestions?J Pediatr
34
Gastroenterol Nutr 2001; 32:50-53.
35
25- Lahoti D, Broor SL. (1993). Corrosive injury to the upper gastrointestinal tract.Indian J Gastroenterol 1993;
36
12:135-141.
37
26- Gorman RL, Khin-Maung-Gyi MT, Klein-Schwartz W, Oderda GM, Benson B, Litovitz T, et al. Initial symptoms
38
as predictors of esophageal injury in alkaline corrosive ingestions. Am J Emerg Med 1992; 10:189-194.
39
27- Nuutinen M, Uhari M, Karvali T, Kouvalainen K.Consequences of caustic ingestions in children. Acta Paediatr
40
1994; 83:1200-1205.
41
28- Gaudreault P, Parent M, McGuigan MA. Predictability of esophageal injury from signs and symptoms: a study of
42
caustic ingestions in 378 children. Pediatrics 1993; 71:767–770.
43
29- Ferguson MK, Migliore M, Staszak VM. Early evaluation and therapy for caustic esophageal injury. Am J Surg
44
1999; 157:116–120.
45
30- Moore WR. Caustic ingestions: pathophysiology, diagnosis, and treatment. Clin Pediatr 1996; 25:192–196.
46
31- Friedman EM.Caustic ingestions and foreign bodies in the aerodigestive tract of children. Pediatr Clin North Am
47
1999; 36:1403–1410.
48
32- Ashcraft KW, Simon JL. Accidental caustic ingestion in childhood: a review: pathogenesis and current concepts of
49
treatment. Tex Med 1992; 68:86–88.
50
33- Gorman RL, Khin-Maung-Gyi MT, Klein-Schwartz W. Initial symptoms as predictors of esophageal injury in
51
alkaline corrosive ingestions. Am J Emerg Med 1992; 10:189–194.
52
34- Christesen HBT. (1995). Prediction of complications following unintentional caustic ingestion in children: is
53
endoscopy always necessary? Acta Paediatr 1995; 84:1177–1182.
54
35- Erdogan E, Eroglu E, Tekant G, Yeker Y, Emir H, Sarimurat N, et al. Management of esophagogastric corrosive
55
injuries in children. Eur J Pediatr Surg 2003; 13:289-293.
56
36- de Jong AL, Macdonald R, Ein S, Forte V, Turner A. Corrosive esophagitis in children: a 30-year review. Int J
57
Pediatr Otorhinolaryngol 2001; 57:203-211.
58
37- Keh SM, Onyekwelu N, McManus K, McGuigan J.Corrosive injury to upper gastrointestinal tract: Still a major
59
surgical dilemma.World J Gastroenterol 2006; 12:5223-5228.
60
38- Schaffer SB, Hebert AF. Caustic ingestion.J La State Med Soc 2000; 152:590-596.
61
39- Zargar SA, Kochhar R, Nagi B, Mehta S, Mehta SK. Ingestion of strong corrosive alkalis: spectrum of injury to
62
upper gastrointestinal tract and natural history.Am J Gastroenterol 1992; 87: 337-341.
63
40- Nunes AC, Romãozinho JM, Pontes JM, Rodrigues V, Ferreira M, Gomes D, et al. Risk factors for stricture
64
development after caustic ingestion.Hepatogastroenterology 2002; 49:1563-1566.
65
41- Andreoni B, Farina ML, Biffi R, Crosta C. Esophageal perforation and caustic injury: emergency management of
66
caustic ingestion.Dis Esophagus 1997; 10:95-100.
67
42- Romanczuk W, Korczowski R. The significance of early panendoscopy in caustic ingestion in children. Turk J
68
Pediatr 1992; 34:93-98.
69
ORIGINAL_ARTICLE
Accuracy Rate for Clinical Diagnosis of Dermatofibroma in Patients Referred to Dermatology and Pathology Department of Emam Reza Hospital
Introduction Considering its typical clinical manifestation, Dermatofibroma (DF) can be clinically diagnosed in most cases. It has been nevertheless, common practice to rely on pathologic diagnoses. We decided to estimate the rate of correct clinical diagnosis and also the relative importance of other lesions in differential diagnosis of DF. Materials and Methods We studied archived biopsies in Dermatology and Pathology Department of Emam Reza hospitals from 1984 untill 2004 and Dermatofibroma cases were selected, then slides were reviewed. Demographic and other relevant data such as age, sex, etc were gathered and analysed. Results Eighty two of 127 clinically diagnosed dermatofibroma cases were confirmed by histologic examination (positive predictive value 64.5%). The most common histological diagnosis in the remaining 45 cases were nodular hidradenoma (7 cases) and comedon and epidermal cyst (11 cases collectively). In addition, 32 cases of histologically diagnosed dermatofibroma were found with different clinical diagnosis. According to our data, the sensitivity of clinical diagnosis was 72%. It was also found that the lesion is more common in females (57%) and in extremities (58%). It often appears as a nodular (72%) lesion measuring 5 to 15 millimeters. Conclusion Histopathologic examination is important for diagnosis of Dermatofibroma. According to our data, the probabilities of false positive and false negatives were 35.5% and 28%, respectively, which is equivalent to 64.5% positive predictive value (PPV).
https://mjms.mums.ac.ir/article_5407_43822cce9266a60e920a01156865358c.pdf
2010-03-21
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10.22038/mjms.2010.5407
Criteria
Correct clinical diagnoses
Dermatofibroma
Patholog
Vahid
Mashayekhi ghoyonlo
1
Assistant Professor of Dermatology, Mashhad University of Medical Sciences, Emam Reza HospitalMashhad, Iran
AUTHOR
Masoud
Maleki
maleki.masoud@gmail.com
2
Assistant Professor of Dermatology, Mashhad University of Medical Sciences, Emam Reza HospitalMashhad, Iran
AUTHOR
Bita
Safaie
3
Resident of PathologyMashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Elham
Arghami
4
General physician
AUTHOR
Mohammad
Ebrahimirad
5
Dermatologist
LEAD_AUTHOR
1- Stevens A, Wheater PR, Lowe JS. Clinical dermatopathology :A Text and colore Atlas. Edinburgh :Churchill
1
Livingstone;1989.p.12-30.
2
2.- alonje E, Mackie RM. Soft tissue tumors and tumor like conditions. In : Burn T, Breathnach S,Cox N, Griffiths C.
3
Rook’s textbook of Dermatology. 7th ed. Oxford:Blackwell science; 2004.p.53.1-25.
4
3- Zelger B,Zelger BG,Burgdorf W. Dermatofibroma-A Critical Evaluation. Int J Surg Pathol 2004; 12: 333-344.
5
4 - Vilanova JR, Flint A. The morphological variations of fibrous histiocytomas. J Cutan Pathoi 1974; 1:l 55-64.
6
5- Fukamizu H,Oku-T,Inoue K,Inoue K,Matsumoto K,Okayama H,Tagami H.Atypical ("pseudosarcomatous')
7
cutaneous histiocytoma. J Cutan Pathol 1983; 10:327-33.
8
6- Tamada S, Ackerman AB. Dermatofibroma with monster cells. Am J Dermatopathol 1987; 9:380-387.
9
7- Cerio R, Spaull J, Jones EW. Histiocytoma cutis: a tumor of dermal dendrocytes (dermal dendrocytoma). Br J
10
Dermatol 1989; 120:197-206.
11
8- Ray MH, Smoller BR, McNutt NS, Hsu A, Weber J. Giant dermal dendrocytoma of the face: a distinct
12
clinicopathologic entity. Arch Derrnatol 1990; 126:689-690.
13
9- Kamino H, Lee JY-Y, Berke A. Pleomorphic fibroma of the skin: a benign neoplasm with cytologic atypia. Am J
14
Surg Pathol 1989; 13:107-13.
15
10- Leyva WH, Santa Cruz DJ. Atypical cutaneous fibrous histiocytoma. Am J Dermatopathol 1986; 8:467-47I.
16
11- Ackerman AB, Troy JL, Rosen LB. Differential diagnosis in dermatopathology II. Philadelphia: Lea & Febiger;
17
1988.p.74-77.
18
12- Fretzin DF, Helwig EB. Atypical fibroxanthoma of the skin: a clinicopathologic study of 140 cases. Cancer 1973;
19
31:1541-1552.
20
13- Santa Cruz D J, Kyriakos M. Aneurysmal (angiomatoid) fibrous histiocytoma of the skin. Cancer 1981; 47:2053-2061.
21
14- Hendricks WM. Dermatofibroma occurring in a smallpox vaccination scar. J Am Acad Dermatol 1987; 16:146-147.
22
15- Puig L, Esquius J, Fernfindez-Figueras MT, Moreno A, Moragas J. Atypical polypoid dermatofibroma: Report of
23
two cases. J Am Acad Dermatol 1991; 24:561-565.
24
16- Hügel H. Fibrohistiocytic skin tumors. J Dtsch Dermatol Ges 2006; 4:544 – 554.
25
17- Heenan PJ. Tumors of Fibrous tissue involving the skin. In :Elder DE, Elenitsas R, Sohnson BL, Murphy GF.
26
Lever’s histopathology of the skin. 9th
27
ed. Philalelphia: Lippincott Williams & Wilkins ; 2005.p. 979-1015.
28
18- Fletcher CD.Benign fibrous histiocytoma of subcutanrous and deep soft tissue: A clinicopathologic analysis of 21
29
cases. Am J Surg Pathol 1990; 14:801-809.
30
19- Gonzalez S, Duarte I. Benign fibrous histiocytoma of the skin. A morphologic study of 290 cases.Pathol Res Pract
31
1982; 174:379-391.
32
20- Calonje E, Mentzel T, Fletcher CD. Cellular benign fibrous histiocytoma. Clinicopathologic analysis of 74 cases of a
33
distinctive variant of cutaneous fibrous histiocytoma with frequent recurrence.Am J Surg Pathol 1994; 18:668-676.
34
21- Franquemont DW, Cooper PH, Shmookler BM, Wick MR. Benign fibrous histiocytoma of the skin with potential
35
for local recurrence: a tumor to be distinguished from dermatofibroma. Mod Pathol 1990; 3:158-163.
36
22- Kaddu S, McMenamin ME, Fletcher CD. Atypical fibrous histiocytoma of the skin: clinicopathologic analysis of
37
59 cases with evidence of infrequent metastasis. Am J Surg Pathol 2002; 26:35-46.
38
ORIGINAL_ARTICLE
Evaluation Effect of Topical Zinc Oxide Ointment on Healing of the Open Wounds Due to Surgery of Pilonidal Sinus
Introduction Pilonidal sinuses typically occur in the midline of the sacrococcygeal skin of young men that is treatment is surgical management. Since its wound healing typically requires long time and information about benefits of zinc compounds in wound healing, we asked to evaluate of the effect of topical zinc oxide ointment on healing of the acute open wounds due to surgery of pilonidal sinus. Materials and Methods In double blind, randomized, placebo control study sixteen men were not been diabetic, renal failure or cirrhotic and not used corticosteroids, after surgery with complete simple excision approach, evaluated in two groups that have been dressed daily with topical zinc oxide ointment (case group) and placebo (control group). Every 15 days average of percentage of wound healing has been compared in two groups by measuring of volume of wounds. Results Mean of age in patients was 24.5±4, has no significant difference in groups (p= 0.634). Means of percentage of volume changes in first and second 15 days have no significant difference in groups (p= 0.334), (p= 0.175). But means of percentage of volume changes in third 15 days and in total 45 days duration of treatment have significant difference (p= 0.006), (p= 0.026). Conclusion In attention to this study and other searches, dressing with zinc oxide ointment is benefit in increase of healing rate of chronic and acute wounds. The effect of drug is significant in third 15 days that is properly because of principle effect of zinc in epithelialization phase.
https://mjms.mums.ac.ir/article_5408_d195e18622b7ab9c0b2dbdf9c6b39f62.pdf
2010-03-21
48
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10.22038/mjms.2010.5408
Open wound
Pilonidal sinus
Wound healing
Zinc oxide ointment
Setareh
Soltani
1
Associated Professor of General surgery, Semnan University of medical sciences, Semnan, Iran
LEAD_AUTHOR
Housein
Naghedinia
2
General Physician, Department Surgery of Amiralmomenin hospital, Semnan, Iran
AUTHOR
Raheb
Ghorbani
3
Associated Professor of Biostatistics, Semnan University of medical sciences, Semnan, Iran
AUTHOR
1- Sabiston David C. SABISTON The text book of surgery. 17thed. Sunders; 2004.p.1500.
1
2- Robert J Baker, Josef E Fischer. MASTERY of surgery. 4th ed. Lippincot Williams & wilkins; 2001.p.1650, 1651.
2
3- Chiedozi LC, Al-Rayyes FA, Salem MM, Al-Haddi FH, Al-Bidewi AA. Management of pilonidal sinus. Saudi Med J
3
2002; 23:786-788.
4
4- Seleem MI, Al-Hashemy AM. Management of pilonidal sinus using fibrin glue: a new concept and preliminary
5
experience. Colorectal Dis 2005; 7:319-322.
6
5- Petre J Morris, Ronald A Malt. OXFORD text book of surgery; 1sted. Oxford medical publication;1994.p.1154, 1155.
7
6- Wood RA, Williams RH, Hughes LE. Foam elastomer dressing in the management of open granulating wounds:
8
experience with 250 patients. Br J Surg 1977; 64:554-557.
9
7- Walker AJ, Shouler PJ, Leicester RJ. Comparison between Eusol and Silastic foam dressing in the postoperative
10
management of pilonidal sinus. J R Coll Surg Edinb 1991; 36:105-106.
11
8- Stevens J, Chaloner D. Urgosorb dressing: management of acute and chronic wounds. Br J Nurs 2005; 7;14:S22-28.
12
9- Kietzmann M, Braun M. Effects of the zinc oxide and cod liver oil containing ointment Zincojecol in an animal
13
model of wound healing. Dtsch Tierarztl Wochenschr 2006;113:331-334.
14
10- Agren MS, Soderberg TA, Reuterving CO, Hallmans G, Tengrup I. Effect of topical zinc oxide on bacterial growth
15
and inflammation in full-thickness skin wounds in normal and diabetic rats. Eur J Surg 1991;157:97-101.
16
11- Cameron J, Hoffman D, Wilson J, Cherry G. Comparison of two peri-wound skin protectants in venous leg ulcers: a
17
randomised controlled trial. J Wound Care 2005; 14:233-236.
18
12- Baatenburg de Jong H, Admiraal H. Comparing cost per use of 3M Cavilon No Sting Barrier Film with zinc oxide
19
oil in incontinent patients. J Wound Care 2004; 13:398-400.
20
13- Jin L, Murakami TH, Janjua NA, Hori Y. The effects of zinc oxide and diethyldithiocarbamate on the mitotic index
21
of epidermal basal cells of mouse skin. Acta Med Okayama 1994; 48:231-236.
22
14- Lewis R, whiting P. Arapid and systemic review of the clinical effectivness and cost-effectiveness of debriding
23
agent in treating surgical wound healing by secondary intention. Health Technol Assess 2001; 5:11-31
24
15- Barceloux DG. Zinc. J Toxicol Clin Toxicol 1999; 37:279-292.
25
16- Agren MS, Ostenfeld U, Kallehave F, Gong Y, Raffn K, Crawford ME, Kiss K, et al. A randomized, double-blind,
26
placebo-controlled multicenter trial evaluating topical zinc oxide for acute open wounds following pilonidal disease
27
excision. Wound Repair Regen 2006; 14:526-535.
28
17- Agren MS, Franzen L, Chvapil M. Effects on wound healing of zinc oxide in a hydrocolloid dressing. J Am Acad
29
Dermatol 1993; 29:221-227.
30
18- Overbeek ST, Tham LM. Effect of zinc oxide tape on plantar ulcers in leprosy patients in Indonesia. Ned Tijdschr
31
Geneeskd. 1991; 135:1350-1353.
32
19- Cangul IT, Gul NY, Topal A, Yilmaz R. Evaluation of the effects of topical tripeptide-copper complex and zinc
33
oxide on open-wound healing in rabbits. Vet Dermatol 2006; 17:417-423.
34
20- Agren MS. Studies on zinc in wound healing. Acta Derm Venereol Suppl (Stockh) 1990; 154:1-36.
35
21- Hallmans G, Lasek J. The effect of topical zinc absorption from wounds on growth and the wound healing process
36
in zinc-deficient rats. Scand J Plast Reconstr Surg 1985;19:119-125.
37
22- Lansdown AB, Mirastschijski U, Stubbs N, Scanlon E, Agren MS. Zinc in wound healing: theoretical,
38
experimental, and clinical aspects. Wound Repair Regen 2007; 15:2-16.
39
23- Agren MS, Ostenfeld U, Kallehave F, Gong Y, Raffn K, Crawford ME, et al. A randomized, double-blind, placebocontrolled
40
multicenter trial evaluating topical zinc oxide for acute open wounds following pilonidal disease excision.
41
Wound Repair Regen 2006; 14:526-535.
42
ORIGINAL_ARTICLE
A Pelvic Hydatid Cyst Presenting with Lower Limb Edema
Hydatid disease is an infection caused by larval stage of Echinococcus granulosus in humans, which are carried as tapeworms by canines. The most frequent organs affected in humans are liver and lungs. We presented a case of pelvic hydatic cyst which is a rare occurrence. Case report There was a 75 years old man with a history of admission for left lower limb edema suspected to DVT. The patient was suffering from generalized abdominal pains especially in LLQ. On pelvic ultrasound and CT scan, a cystic mass with internal septation on the left side of pelvis was reported. After surgery, pathology report of removed cyst confirmed the hydatid cyst. Conclusion In endemic regions, in patients complaining of lower limb edema and suspected to have DVT, pelvic mass lesions such as hydatic cyst should be born in mind.
https://mjms.mums.ac.ir/article_5409_a00b6b934c8f15315e197cb25349c485.pdf
2010-03-21
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10.22038/mjms.2010.5409
Echinococcus granulosus
Hydatid Cyst
Pelvic
Amirmansour
Kalali
1
Specialist in infectious Diseases, Razi Hospital, Joundishapour University of Medical Sciences, Ahvaz, Iran
LEAD_AUTHOR
Sayed Mohammad
Alavi
2
Associate Professor of Infection Diseases,Razi Hospital, Joundishapour University of Medical Sciences, Ahvaz, Iran
AUTHOR
Farid
Yosefi
3
Assistant Professor of Infection Diseases,Razi Hospital, Joundishapour University of Medical Sciences, Ahvaz, Iran
AUTHOR
Mohammad
Nadimi
4
Rezident Infection Diseases,RaziHospital, Joundishapour University of Medical Sciences, Ahvaz, Iran
AUTHOR
1- Mandell G, Bennett J, Dolin R. Principles and practice of infectious diseases. 6th ed. New York: Churchill
1
Livingstone; 2005.p.3290-3291.
2
2- Cook GC, Zumla AI. Manson’s tropical diseases. 21st ed. London: Saunders; 2003. p.1561-1568.
3
3- Craig PS, McManus DP, Lightlowlers MW, Chabalgoity JA, Garcia HH, Gavidia CM, et al. Prevention and control
4
of cystic echinococcosis. Lancet Infect Dis 2007; 7:385.
5
4- Moreno-Gonzalez E, Segurola CL, García Ureña MA, García García I, Gómez Sanz R, Jiménez Romero C, et al.
6
Liver transplantation for Echinococcus granulosus hydatid disease.
7
Transplantation 1994; 58:797-800.
8
5- Vijayan VK. How to diagnose and manage common parasitic pneumonias. Curr Opin Pulm Med 2007; 13:218-224.
9
6- Benomar A, Yahyaoui M, Birouk N, Vidailhet M, Chikili T. Middlecerebral artery occlusion due to hydatid cysts
10
of myocardial and intraventricular cavity cardiac origin: 2 cases. Stroke 1994; 25:886-888.
11
7- Yagmur O, Demircan O, Atilla E. Cardiac tamponade due to rupture of hydatid cyst into the pericardium. Dig surg.
12
1992; 9:329-331.
13
8- Agarwal DK, Agarwal R, Barthwal SP. Interventricular septal hydatid cyst presenting as complete heart block. Br
14
Heart J 1996; 75: 266.
15
9- Sinha PR, Jaipuria N, Avasthey P. Intracardiac hydatid cyst and sudden death in a child. Int J Cardiol 1995;
16
51:293-295.
17
10- Gogus C, Safak M, Baltaci S, Turkolmez K. Isolated renal hydatidosis: experience with 20 cases. J Urol 2003;
18
169:186-189.
19
11- Gelman R, Brook G, Green J, Ben-Itzhak O, Nakhoul F. Minimal change glomerulonephritis associated with
20
hydatid disease. Clin Nephrol 2000; 53:152-155.
21
12- Ali-Khan Z, Rausch RL. Demonstration of amyloid and immune complex deposits in renal and hepatic parenchyma
22
of Alaskan alveolar hydatid disease patients. Ann Trop Med Parasitol 1987; 81:381-392.
23
13- Salinas JC, Torcal J, Lozano R, Sousa R, Morandeira A, Cabezali R. Intracystic infection ofliver hydatidosis.
24
Hepatogastroentrology 2000; 47:1052-1055.
25
14- Bounaim A, Sakit F, Janati IM. Primary pelvic hydatid cyst: a case report. Med trop (Mars) 2006; 66:279-281.
26
15- Emir L, Karabulut A, Balci U, Germiyanoqlu C, Erol D. An unusual cause of urinary retention: a primary
27
retrovesical echinococcal cyst. Urology 2000; 56:856.
28
16- Halefoqlu AM, Yasar A. Huge retrovesical hydatid cyst with pelvic localization as the primary site: a case report.
29
Acta Radiol 2007; 48:918-920.
30
17- Safioleas M, Stamatakos M, Zervas A, Agapitos E. Solitary hydatid cyst in the pelvis: A case report. Int Urol
31
Nephrol 2006; 38: 491-492.
32
18- Yurdakul T, Pişkin MM. Pelvic hydatid disease causing renal failure. Ankara Ǘniversitesi Tip Fakǘltesi Mecmuasi
33
2006; 59:80-82.
34
19- Sanal HT, Kocaoglu M, Bulakbasi N, Yildirim D. Pelvic hydatid disease: CT and MRI findings causing sciatica.
35
Korean J Radiol 2007; 8:548-551.
36
20- Gupta A, Kakkar A, Chadha M, Sathaye CB. A primary intrapelvic hydatid cyst presenting with foot drop and a
37
gluteal swelling: a case report. J Bone joint Surg [Br] 1998; 80-B: 1037-1039.
38
21- Varedi P, Saadat Mostafavi SR, Salouti R, Saedi D, Nabavizadeh SA, Samimi K, et al. Hydatidosis of the pelvic
39
cavity: a big masquerade. Infect Dis Obstet Gynecol 2008; 2008:782621.
40