Diagnostic value of frozen sections in patients with breast and thyroid pathologies in Hospitals of Babol University of medical sciences 2011 to 2016

Document Type : Research Paper

Authors

1 Student research Committee , Babol University Of Medical Sciences , Babol , I.R Iran.

2 Cancer Research Center, Health Research Institute, Department of Surgery, School of Medicine , Babol University of Medical, Babol, Iran.

3 General Surgeon, Babol University of Medical Sciences,Babol,Iran.

4 Infertility and Health Reproductive Research Center, Health Research Institute, Department of Pathology, School of Medicine , Babol University of Medical Sciences, Babol, I.R.Iran.

5 Cellular and Molecular Biology Research Center, Health Research Institute, Department of Pathology, School of Medicine, Babol University of Medical Sciences, Babol, I.R.Iran.

6 Clinical Research Development Center, Shahid Beheshti Hospital, Babol University of Medical Sciences, Babol, I.R.Iran.

Abstract

Abstract
Introduction: this study aimed to determine the diagnostic value of frozen tissue sections in comparison with definitive pathology in terms of its reliability in the diagnosis of breast and thyroid lesions in patients referring to educational hospitals of Babol University of Medical Sciences from 2011-2016.
Materials and Methods: all patients who underwent thyroidectomy or breast surgery due to a mass that frozen sections was performed were included. Patients demographic characteristics, frozen section diagnosis and Permanent pathology diagnoses were collected and analized.
Results: Of 137 cases(104 cases of thyroid and 33 cases of breast)  who required frozen section,totally, 91 cases (66.4%) were reported benign lesions and 46 cases (33.6%) were reported malignant. Also, based on a permanent diagnosis, 52 cases (38.0%) were malignant and 85 (62.0%) were benign.The diagnostic value of the frozen section in detecting malignant thyroid lesions was 63% sensitivity, specificity was 99%, the positive predictive value was 92%, negative predictive value was 92%, and diagnostic accuracy was 92.3%. In cases of breast, the result of frozen tissue sections is consistent with permanent pathology, therefore, the diagnostic value of frozen tissue sections in determining the malignant lesions of the breast can not be calculated.
Conclusion: Considering the high rate of consistency of frozen sections with permanent pathology in breast and thyroid lesions, it can be concluded that the frozen tissue section is considered as a precise and valuable method.

Keywords

References

  1. Howanitz PJ, Hoffman GG, Zarbo RJ. The accuracy of frozen-section diagnoses in 34 hospitals. Arch Pathol Lab Med 1990; 114:355-9.
  2. Mahe E, Ara S, Bishara M, Kurian A, Tauqir S, Ursani N, et al. Intraoperative pathology consultation: error, cause and impact. Can J Surg 2013; 56:E13-8.
  3. Shrestha S, Basyal R, Pathak T, Lee M, Dhakal H, Pun M, et al. Comparative study of frozen secton diagnoses with histopathology. Post Grad Med NAMS 2009; 9:1-5.
  4. Baloch ZW, LiVolsi VA. Intraoperative assessment of thyroid and parathyroid lesions. Semin Diagn Pathol 2002; 19:219-26.
  5. Mayooran N, Waters PS, Kaim Khani TY, Kerin MJ, Quill D. FNAC and frozen section correlations with definitive histology in thyroid diseases. Eur Arch Otorhinolaryngol 2016; 273:2181-4.
  6. Hatami H, Mohsenifar Z, Alavi SN. The diagnostic accuracy of frozen section compared to permanent section: a single center study in Iran. Iran J Pathol 2015; 10:295-9.
  7. Kumar M, Potekar R, Ramling Yelikar B, Patil V, Karigoudar M, Pande P. Diagnostic accuracy of frozen section in comparison with fine needle aspiration cytology in thyroid lesions–a prospective study. Iran J Pathol 2013; 8:219-26.
  8. Bollig CA, Gilley D, Lesko D, Jorgensen JB, Galloway TL, Zitsch RP 3rd, et al. Economic impact of frozen section for thyroid nodules with “suspicious for malignancy” cytology. Otolaryngol Head Neck Surg 2018; 158:257-64.
  9. Baloch ZW, LiVolsi VA. Intraoperative assessment of thyroid and parathyroid lesions. Semin Diagn Pathol 2002; 19:219-26.
  10. Rahbar M, Kanani M, Khazaei S, Shahi M. Diagnostic value of frozen section and permanent sections. J Babol Univ Med Sci 2008; 10:31-5.
  11. Kobayashi K, Ando K, Ito K, Tsushima M, Morozumi M, Tanaka S, et al. Accuracy of intraoperative pathological diagnosis using frozen sections of spinal cord lesions. Clin Neurol Neurosurg 2018; 167:117-21.
  12. Karve PV, Jambhekar NA, Desai SS, Chinoy RF. Role of frozen section evaluation in patients with breast lumps: a study of 251 cases. Indian J Surg 2005; 67:248.
  13. Afsharmoghaddam N, Heidarpour M, Salehi F, Mehrabi KA. Diagnostic value of frozen section compared to permanent pathology in breast and ovarian masses. J Isfahan Med Sch 2016; 34:232-7.
  14. Bianchi S, Palli D, Ciatto S, Galli M, Giorgi D, Vezzosi V, et al. Accuracy and reliability of frozen section diagnosis in a series of 672 nonpalpable breast lesions. Am J Clin Pathol 1995; 103:199-205.
  15. Suarez-Zamora DA, Barrera-Herrera LE, Palau-Lazaro MA, Torres-Franco F, Orozco-Plazas A, Barreto-Hauzeur L, et al. Accuracy and interobserver agreement of retroareolar frozen sections in nipple-sparing mastectomies. Ann Diagn Pathol 2017; 29:46-51.
medical journal of mashhad university of medical sciences
Volume 62, Issue 3
July and August 2019
Pages 1500-1505

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