Medical Journal of Mashhad university of Medical Sciences

Medical Journal of Mashhad university of Medical Sciences

effect of selenium on thyrotropin TSH and anti TPO Ab in autoimmune hypothyroid patients

Document Type : Research Paper

Authors
zahra mazloum khorasani 1
zohreh jahani 2
Bibi Marjan Razavi 3
Monavvar Afzalaghaee 4
1 Associate Professor of endocrinology Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
2 Resident of Internal Medicine,Mashhad University of Medical Sciences, Mashhad, Iran.
3 Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
4 Associate Professor of Community Medicine Department of Epidemiology and Biostatistics, School of Health Social Determinants of Health Research Center Mashhad University of Medical Sciences
10.22038/mjms.2022.57555.3368
Abstract
Hypothyroidism is one of the most common endocrin disorders.in many country autoimmune hypothyroidism is the most cause of overt hypothyroidism. Base of above point and common prevalence of hypothyroidism in our population we decide to evaluate the relationship between selenium and anti thyroid proxidase antibody and if there is relation ship we recommende selenium therapy in auto immune hypothyroidism.
A double blind and placebo-controlled prospective study was performed in50 auto immune hypothyroid patients. all patients that referred to endocrinology clinic of Ghaem hospital and obtain entry condition and informed consent were randomly assigned to intervention and control group with table of random number. Physical examination and review of system were done and Serum concentrations of anti TPO Ab , thyroid-stimulating hormone (TSH), free thyroxine (free t4) were measured at baseline and after 3 months of follow-up.. intervention group take 200 Mcg selenium capsule and 50-100 Mcg Levothyroxin(base on patient BMI) per day. control group take placebo(wheat bran) and 50-100 Mcg Levothyroxin(base on patient BMI)per day. Serum concentrations of anti TPO Ab , thyroid-stimulating hormone (TSH), free thyroxine (free t4) were measured at baseline and after 3 months of follow-up..
50 patients include 11 males and 39 females with mean ages (36/42),TSH(21/22),anti TPO Ab(424/78),free T4(0.829).there in no significant differences in TSH(p=0/165 ),anti TPO Ab(p=0/727),free T4(p=0/785) after intervention between 2 groups.

Selenium had some effect on thyroid function testes such as TSH and anti TPO Ab suppresion with T4 elevation but there is no significant differences in 2 groups
Keywords
hypothyroid
selenium
thyrotropin
anti TPO
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Medical Journal of Mashhad university of Medical Sciences
Volume 65, Issue 1
May and June 2022
Pages 39-45