Medical Journal of Mashhad university of Medical Sciences

Medical Journal of Mashhad university of Medical Sciences

Changes in FoxO1 gene expression in subcutaneous adipose tissue and lipid profile following high intensity interval training in high fat diet-induced obese rats

Document Type : Research Paper

Authors
Masoud Saki 1
Davood Khorshidi 2
Hamidreza Samarikhalaj 3
1 MSc in Exercise Physiology, Department of Physical Education and Sport Sciences, Saveh Branch, Islamic Azad University, Saveh, Iran
2 Assistant Professor of Exercise Physiology, Department of Physical Education and Sport Sciences, Saveh Branch, Islamic Azad University, Saveh, Iran
3 Assistant Professor of Sport Management, Department of Physical Education and Sport Sciences, Saveh Branch, Islamic Azad University, Saveh, Iran
10.22038/mjms.2022.67035.3969
Abstract
Introduction: FoxO1 is a transcription factor involved in energy metabolism, which contributes to the pathology of metabolic disorders, including obesity and diabetes. The purpose of this study was to investigate the effect of six weeks of high intensity interval training (HIIT) on FoxO1 gene expression in subcutaneous adipose tissue and lipid profile of high fat diet-induced obese male rats.
Methods: In this experimental study, fourteen male Wistar rats were fed a high-fat diet for six weeks, then were randomly divided into training (n=7) and control (n=7) groups. The training group performed the HIIT protocol on a treadmill for six weeks. FoxO1gene expression in subcutaneous adipose tissue and lipid profile were measured after the last training session. Data were analyzed by independent T test.
Results: There was no significant difference in the FoxO1 gene expression between the two groups after interval training (P>0.05). The levels of cholesterol and high-density lipoprotein were significantly lower and higher respectively in the training group compared to the control group (P˂0.05). No significant difference was found in triglycerid and low-density lipoprotein levels between the two groups (P˃0.05).
Conclusion: It seems that six weeks of HIIT in obese rats can improve the lipid profile without changing FoxO1 gene expression in subcutaneous adipose tissue.
Keywords
Exercise
Obesity
lipid profile
FoxO1 gene
Medical Journal of Mashhad university of Medical Sciences
Volume 65, Issue 4
May and June 2022