The present study was conducted with the aim of predicting death obsession based on anxiety sensitivity, mindfulness and psychological toughness in people with type 2 diabetes. The current descriptive-correlation study and the statistical population included men and women with type 2 diabetes in Tehran between May and November 2022, from which 134 people were selected by convenience sampling. The data were obtained using the death obsession scale of Abdul Khaliq (1998), the anxiety sensitivity questionnaire (ASI) of Reiss and Patterson (1985), the FFMQ mindfulness questionnaire of Bayer et al. (2006) and the psychological toughness scale of Ahvaz Kiamarthi et al. Came. The data obtained from the implementation of the research were analyzed using the methods of descriptive statistics and inferential statistics (correlation matrix) as well as the analysis of the raw data obtained from the research in the software (SPSS). The results showed that the variable of anxiety sensitivity has a direct effect on death anxiety (0.735), the variable of psychological toughness has an inverse effect on the variable of death anxiety (-0.251), and the variable of mindfulness has an inverse effect on the anxiety variable. Death has an effect (-0.219). It can be concluded that death anxiety can be predicted based on anxiety sensitivity, psychological toughness, and mindfulness, and anxiety sensitivity, psychological toughness, and mindfulness variables are predictors for death anxiety.