Medical Journal of Mashhad university of Medical Sciences

Medical Journal of Mashhad university of Medical Sciences

Comparative study of the infusion of ketorolac and Pethidine in reducing postoperative pain in patients undergoing orthopedic surgery of lower limbs under spinal anesthesia

Document Type : Research Paper

Authors
Shahram Shafa 1
Hasan Zabetian 2
Ameneh Ranjbar 3
Navid Kalani 2
1 Department of Orthopedics, Jahrom University of Medical Sciences, Jahrom, Iran.
2 Department of Anesthesiology, Jahrom University of medical sciences, Jahrom, Iran.
3 Student research committee, Jahrom University of medical sciences, Jahrom, Iran
10.22038/mjms.2024.79263.4558
Abstract
Introduction: Pain after surgery is an unpleasant experience that occurs following various stimuli and people react to it. This process causes physiological disorders in all systems of the body.
Method: In this three-way, randomized clinical trial, 59 patients with anesthesia classes 1 and 2 underwent lower limb orthopedic surgery with spinal anesthesia. Patients were divided into 4 groups: pethidine, ketorolac, placebo and a combination of ketorolac and pethidine. VAS criterion was used to measure patients' pain.
Results: There was no statistically significant difference between ketorolac, pethidine, placebo and ketorolac + pethidine groups in terms of systolic and diastolic blood pressure and heart rate. Oxygen saturation percentage before and after spinal was significant 15 minutes after surgery (p <0.05). But at other times there was no significant difference (p> 0.05). There was a significant difference in terms of pain in recovery at 6 and 12 hours after surgery (p <0.05). But at other times, the difference was not significant. At 6 hours postoperatively, severe pain was observed in patients in the pethidine and placebo groups and in patients in the ketorolac + pethidine and ketorolac groups; However, at 12 hours postoperatively, severe pain was more common in patients in the pethidine group than in the other groups and was not present in patients in the ketorolac + pethidine group.
Conclusion: The results of this study showed that ketorolac and the combination of ketorolac + pethidine reduce analgesia in patients undergoing orthopedic lower limb surgery.
Keywords
Ketorolac
Pethidine
Orthopedics
Spinal Anesthesia
Analgesia
Subjects
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Medical Journal of Mashhad university of Medical Sciences
Volume 67, Issue 2
March and April 2024
Pages 505-521