Medical Journal of Mashhad university of Medical Sciences

Medical Journal of Mashhad university of Medical Sciences

The Effect of 8 Weeks Ginger Supplementation on Serum Creatine Kinase and Lactate Dehydrogenase in Response to Exhaustive Exercise in Female Taekwondo Athletes

Document Type : Research Paper

Authors
sara zare karizak 1
Gol Pari Jafari 2
Abdossaleh Zar 3
1 Assistant Professor of Sport Science Department, Faculty of Literature and Humanities, Persian Gulf University, Boushehr, Iran.
2 MSc Student of Sport Science Department, Faculty of Literature and Humanities, Persian Gulf University, Boushehr, Iran.
3 Associate Professor of Sport Science Department, Faculty of Literature and Humanities, Persian Gulf University, Boushehr, Iran.
10.22038/mjms.2024.76133.4464
Abstract
Introduction

High-intensity exercises are associated with muscle injuries and DOMS.This study aimed to determine the effect of taking 8 weeks of ginger supplementations on serum creatine kinase (CK) and lactate dehydrogenase (LDH) levels in response to exhaustive exercise in female taekwondo athletes.

Methods
In this semi-experimental study,24 female taekwondo athletes (mean age 19.75±2.03 years, height 160±6 cm, weight 53.99±7.49 kg) were selected voluntarily.Subjects were randomly assigned to the ginger supplement + exhaustive (GE+EE) and exhaustive exercise (EE) groups.24 doses of 2000 mg of ginger supplement (3 days/week for 8 weeks) were taken in the morning and evening (4 capsules of 500 mg: 2 in the morning and 2 in the evening).Then Bruce's test was performed as an exhaustive exercise.Blood samples were collected in two stages before and after the intervention, and serum levels of CK and LDH were measured using the ELISA method.The t-test and repeated-measures ANOVA were used to analyze intra-group changes and compare between groups from pre-test to post-test using SPSS version 25 software.

Results
The results showed a significant increase in the level of serum CK(P=0.003) and LDH (P=0.001) in the EE group. In contrast, there was a significant decrease in the level of serum CK (P = 0.05) and LDH (P<0.001) in the group of GE+EE.In addition, there was a significant difference between the group of GE+EE and the EE. (P<0.001).

Conclusion
Taking 8 weeks of ginger supplementation compared to not taking ginger supplementation can effectively reduce muscle injury following exhaustive exercise in female taekwondo athletes.
Keywords
Exhaustive Exercise
Creatine Kinase
Lactate Dehydrogenase
Female Taekwondo Athletes
Iranian Traditional Medicine
Subjects
  1. Kashef A, Zare Karizak S, Sadeghi Nikoo A, Kashef M. Effect of Single Session of High Intensity Interval Exercise on Some Immune and Inflammatory Factors in Male Athletes and the Risk of Infection to Coronavirus. The Journal of Shahid Sadoughi University of Medical Sciences. 2021;28(12):3326-37.
  2. Larsen C, Jensen MP. Rhabdomyolysis in a well-trained woman after unusually intense exercise. Ugeskrift for laeger. 2014;176(25):V01140001-V.

 

  1. Fernández-Lázaro D, Mielgo-Ayuso J, Seco Calvo J, Córdova Martínez A, Caballero García A, Fernandez-Lazaro CI. Modulation of exercise-induced muscle damage, inflammation, and oxidative markers by curcumin supplementation in a physically active population: a systematic review. Nutrients. 2020;12(2):501.
  2. Farias-Junior LF, Browne RAV, Freire YA, Oliveira-Dantas FF, Lemos TMAM, Galvão-Coelho NL, et al. Psychological responses, muscle damage, inflammation, and delayed onset muscle soreness to high-intensity interval and moderate-intensity continuous exercise in overweight men. Physiology & Behavior. 2019;199:200-9.
  3. Cheung K, Hume PA, Maxwell L. Delayed onset muscle soreness. Sports medicine. 2003;33(2):145-64.

 

  1. Connolly DAJ, Sayers SE, McHugh MP. Treatment and Prevention of Delayed Onset Muscle Soreness. The Journal of Strength & Conditioning Research. 2003;17(1).
  2. Nikolaidis MG, Jamurtas AZ, Paschalis V, Fatouros IG, Koutedakis Y, Kouretas D. The effect of muscle-damaging exercise on blood and skeletal muscle oxidative stress: magnitude and time-course considerations. Sports medicine. 2008;38:579-606.
  3. Callegari GA, Novaes JS, Neto GR, Dias I, Garrido ND, Dani C. Creatine kinase and lactate dehydrogenase responses after different resistance and aerobic exercise protocols. Journal of human kinetics. 2017;58:65.
  4. Musaie M, Azarbayjani MA, Peeri M. The responses of creatine kinase and lactate dehydrogenase to acute eccentric activity after saffron supplementation in healthy man. International Journal of Biosciences (IJB). 2013;3(8):319-24.

 

  1. Tsitsimpikou C, Kioukia-Fougia N, Tsarouhas K, Stamatopoulos P, Rentoukas E, Koudounakos A, et al. Administration of tomato juice ameliorates lactate dehydrogenase and creatinine kinase responses to anaerobic training. Food and chemical toxicology. 2013;61:9-13.
  2. Karimzadehfard H, Shadmehri S, Hosseini SA, Molaie A, Kazemi N. The effect of three weeks of β-alanine and creatine supplementation on the response of creatine kinase, lactate dehydrogenase and lactate to an exhausting swimming session in elite swimmers. Razi Journal of Medical Sciences. 2021;28(6):90-9.
  3. Mohammad Qoliha F, Irandoust K, Taheri M, Nabilpour M. The Effect of Dry Cupping Therapy and Creatine Supplementation on Lactic Acid, Lactate Dehydrogenase and Creatine Kinase in Plasma Following Wingate Anaerobic Test in Male Handball Players. Complementary Medicine Journal. 2022;12(3):284-93.
  4. Wilson PB. Ginger (Zingiber officinale) as an analgesic and ergogenic aid in sport: a systemic review. The Journal of Strength & Conditioning Research. 2015;29(10):2980-95.
  5. Black CD, O’Connor PJ. Acute effects of dietary ginger on quadriceps muscle pain during moderate-intensity cycling exercise. International journal of sport nutrition and exercise metabolism. 2008;18(6):653-64.
  6. Jalali, M., Mahmoodi, M., Moosavian, S. P., Jalali, R., Ferns, G., Mosallanezhad, A., & Mosallanezhad, Z. (2020). The effects of ginger supplementation on markers of inflammatory and oxidative stress: a systematic review and meta‐analysis of clinical trials. Phytotherapy Research, 34(8), 1723-1733.
  7. Gibson, A.L., D. Wagner, and V. Heyward, Advanced fitness assessment and exercise prescription, 8E. 2019: Human kinetics.
  8. Black C, O’Connor P. (197) Short term effects of 2-grams of dietary ginger on muscle pain, inflammation and disability induced by eccentric exercise. The Journal of Pain. 2008;9(4):25.
  9. SalimiSafar,Z (2021). Effect of 8 weeks HIIT with ginger supplementation on LDH,CK,IL6,PGE2 in

young female taekwondo athletes. MSc thesis in shahid rajaee university of Tehran, Iran.

  1. Vahdat Poor H, Shakerian S, Alizadeh AA, Fatemi Tabatabaei SR. The Effect of Short-Term Ginger Supplementation on Serum HSCRP and Creatine Kinase in Response to Exhaustive Eccentric Exercise in Overweight Girlَs. Jundishapur Scientific Medical Journal. 2016;15(5):451-550.
  2. Matsumura MD, Zavorsky GS, Smoliga JM. The effects of pre‐exercise ginger supplementation on muscle damage and delayed onset muscle soreness. Phytotherapy Research. 2015;29(6):887-93.

 

  1. Ahmad A, Jusoh N, Tengah R. Acute physiological responses and performance following subsequent CrossFit ‘CINDY’workout with Zea Mays juice. Physical education of students. 2019;23(2):57-63.
  2. Samadi M, Kordi N, Salehpoor S, Iravani OM, Asjodi F. Effect of one and five-day curcumin consumption on muscle damage indices after an eccentric exercise session in untrained young men. Journal of Military Medicine. 2019;21(2):123-30.
  3. Sarkar S, Debnath M, Das M, Bandyopadhyay A, Dey SK, Datta G. Effect of high intensity interval training on antioxidant status, inflammatory response and muscle damage indices in endurance team male players. Apunts Sports Medicine. 2021;56(210):100352.

 

  1. Fang W, Nasir Y. The effect of curcumin supplementation on recovery following exercise‐induced muscle damage and delayed‐onset muscle soreness: A systematic review and meta‐analysis of randomized controlled trials. Phytotherapy Research. 2021;35(4):1768-81.

 

  1. Jiaming Y, Rahimi MH. Creatine supplementation effect on recovery following exercise‐induced muscle damage: A systematic review and meta‐analysis of randomized controlled trials. Journal of food biochemistry. 2021;45(10):e13916.

 

  1. Parsaie N, Ghavamzadeh S, Cheraghi M. Effects of cholecalciferol supplementation on inflammatory markers and muscle damage indices of soccer players after a simulated soccer match. Nutrition. 2019;59:37-43.

 

  1. Mao Q-Q, Xu X-Y, Cao S-Y, Gan R-Y, Corke H, Beta T, et al. Bioactive compounds and bioactivities of ginger (Zingiber officinale Roscoe). Foods. 2019;8(6):185.
  2. Wei CK, Tsai YH, Korinek M, Hung PH, El-Shazly M, Cheng YB, et al. 6-Paradol and 6-Shogaol, the Pungent Compounds of Ginger, Promote Glucose Utilization in Adipocytes and Myotubes, and 6-Paradol Reduces Blood Glucose in High-Fat Diet-Fed Mice. International journal of molecular sciences. 2017;18(1).

 

  1. Arcusa R, Villaño D, Marhuenda J, Cano M, Cerdà B, Zafrilla P. Potential Role of Ginger (Zingiber officinale Roscoe) in the Prevention of Neurodegenerative Diseases. Frontiers in Nutrition. 2022;9.
  2. Karizak SZ, Shahnehzad M, Zar A. Impact of ginger supplementation on serum PGE2, COX2, and IL-6 in response to exhaustive exercise in female taekwondo athletes. Comparative Exercise Physiology. 2024 Feb 7;1(aop):1-6.
  3. Padervand S, Hassani A, KALALIAN MH, Donyaei A. The effect of taking Ginger supplement and progressive endurance training on cellular damage in non-athlete men. 2014.

32        Hosseinzadeh A, Bahrampour Juybari K, Fatemi MJ, Kamarul T, Bagheri A, Tekiyehmaroof N, et al. Protective effect of ginger (Zingiber officinale roscoe) extract against oxidative stress and mitochondrial apoptosis induced by interleukin-1β in cultured chondrocytes. Cells Tissues Organs. 2017;204(5-6):241-50.

  1. Black CD, Herring MP, Hurley DJ, O'Connor PJ. Ginger (Zingiber officinale) reduces muscle pain caused by eccentric exercise. The journal of pain. 2010;11(9):894-903.
  2. Atashak S, Peeri M, Azarbayjani MA, Stannard SR. Effects of ginger (Zingiber officinale Roscoe) supplementation and resistance training on some blood oxidative stress markers in obese men. Journal of Exercise Science & Fitness. 2014;12(1):26-30.
Medical Journal of Mashhad university of Medical Sciences
Volume 67, Issue 5 - Serial Number 5
September and October 2024
Pages 1358-1366