The objective of the present study was the structural model of cognitive Functioning based on quality of life and psychological distress with the mediating role of the family's expressed emotion in people with schizophrenia. The research is applicative and the research method was correlational through structural equations modeling. The statistical population of the study included people suffering from schizophrenia who referred to Shafa and Parham rehabilitation centers in Isfahan in the spring of 2023. 240 people with schizophrenia were selected from the statistical population as the available sampling. The research instruments were Quality of Life Questionnaire, Cognitive Performance Evaluation Questionnaire and Expressed Emotion Questionnaire. The results showed that quality of life has a significant direct effect on cognitive Functioning (p < 0.05, β = 0.512) and family's expressed emotion (p <0.05, β = 0.566) of people with schizophrenia and it was able to explain 26.2 and 32 percent of the variance of these variables, respectively. Also, family's expressed emotion had a significant direct effect on cognitive Functioning (p<0.05, β =-0.457) of people with schizophrenia and was able to explain 20.9% of the variance of this variable. Meanwhile, family's expressed emotion has a significant mediating role in the relationship between quality of life with cognitive Functioning in people with schizophrenia (p<0.05). Considering the significant mediating role of family's expressed emotion, it is possible to improve the executive function of people with schizophrenia by using effective interventions such as emotional management and regulation training that lead to improvement of family members' interactions.