اثر تحریک فراجمجمه ای مغز و تمرینات ثبات مرکزی بر خستگی بیماران مبتلا به مولتیپل اسکلروزیس

نوع مقاله : مقاله پژوهشی

نویسندگان

1 دکترای رفتار حرکتی و کارشناس ارشد کاردرمانی جسمانی، استادیار واحد تهران شرق، دانشگاه آزاد اسلامی، تهران، ایران.

2 استادیار فیزیولوژی ورزشی، گروه تربیت بدنی و علوم ورزشی، دانشکده علوم انسانی، واحد تهران غرب، دانشگاه آزاد اسلامی. تهران، ایران

3 کارشناسی ارشد آسیب شناسی و حرکات اصلاحی، واحد تهران شرق، دانشگاه آزاد اسلامی، تهران، ایران.

4 کارشناس ارشد آسیب شناسی ورزشی و حرکات اصلاحی، واحد تهران شرق، دانشگاه آزاد اسلامی، تهران، ایران.

10.22038/mjms.2025.85695.4908

چکیده

مقدمه: خستگی نشانه‌ای شایع اما نه‌چندان شناخته‌ شده در بیماران مبتلا به ام اس است هدف پژوهش حاضر مقایسه‌ی اثر تحریک فراجمجمه ای مغز و تمرینات ثبات مرکزی بر خستگی بیماران مبتلا به مولتیپل اسکلروزیس بود.
روش کار: پژوهش حاضر تجربی و از نوع پیش آزمون- پس آزمون بود. جامعه آماری آن کلیه بیماران مبتلا به مولتیپل اسکلروزیس مراجعه کننده به بیمارستان توانبخشی رفیده شهر تهران در زمستان 98 بودند که از بین آن ها تعداد 30 نفر بیمار27 الی 70 ساله از هر دو جنس زن و مرد با نمونه گیری در دسترس و هدفمند انتخاب شدند و به صورت تصادفی در دو گروه 15 نفری تجربی و کنترل قرار داده شدند. پس از اندازه گیری میزان خستگی به وسیله‌ی پرسشنامه خستگی چند بعدی، تمرینات ثبات مرکزی 8 هفته (هفته ای 3 جلسه) که هر جلسه حدود 30 تا 40 دقیقه طول کشید و تحریک الکتریکی فراجمجمه ای مخچه، هفته ای 2 جلسه (جلسات اول و سوم هرهفته)، به صورت آنلاین هر جلسه به مدت 20 دقیقه همراه با تمرینات ثبات مرکزی ارائه شد. پس از اتمام مداخله، متغیرهای پژوهش مجدداً اندازه گیری شدند.
نتایج: نتایج تحقیق، حاکی از این است که تحریک الکتریکی مخچه خستگی عمومی (001/0=P)، خستگی جسمی (001/0>P)، کاهش فعالیت (001/0>P)، و ادراک خستگی (001/0>P) بیماران ام اس را کاهش داده است. با این وجود بر کاهش انگیزه (097/0=P) و خستگی ذهنی (080/0=P) این بیماران تاثیری ندارد.
نتیجه گیری: بنابراین تحریک الکتریکی مخچه با جریان مستقیم الکتریکی بر خستگی بیماران ام اس اثرات سودمندی دارد.

کلیدواژه‌ها

موضوعات


عنوان مقاله [English]

The effect of Transcranial Direct Current Stimulation (tDCS) plus core stability training on the Fatigue of patients with multiple sclerosis

نویسندگان [English]

  • seyed kazem mousavi sadati 1
  • Reza Behdari 2
  • Soudabeh Raeisi 3
  • Ghazal Marvastinia 4
1 1. PhD of motor behavior and Master of physical occupational therapy, Assistant professor of East Tehran branch, Islamic Azad university, Tehran, Iran.
2 Assistant professor of exercise physiology, Department of physical Education and sport, West Tehran Branch,Islamic Azad University, Tehran Iran.
3 MSc of Sports injuries and Corrective exercise, East Tehran branch, Islamic Azad university, Tehran, Iran
4 MSc of Sports injuries and Corrective exercise, East Tehran branch, Islamic Azad university, Tehran, Iran.
چکیده [English]

Introduction: Fatigue were reported by physicians as the symptom of Multiple Sclerosis disease. The present study aims at Comparison of the effect of Transcranial Direct Current Stimulation (tDCS) plus core stability training on fatigue of patients with multiple sclerosis.
Materials and methods: This is a pre-test – post-test experiment study. The statistical population included all patients suffering from multiple sclerosis that came to Rofaydeh Rehabilitation Hospital in Tehran, Iran. 30 male and female patients aged 27 to 70 were selected through available and purposive sampling and randomly divided into two experimental and control groups (each group 15 persons). After measuring the amount of fatigue with Multidimensional Fatigue Inventory questionnaire. The participants’ training included core stability training for 8 weeks (30-min to 40-min, 3 sessions per week) with 20 min online cerebellar transcranial direct current stimulation, 2 sessions per week (sessions first and third). Afterward, the research variables were measured again.
Results: The results of this research revealed that the cerebellar current stimulation decreased general fatigue (P=0/001), physical fatigue (P<0/001), activity reduction (P<0/001) and (MFI) (P<0/001) in MS patients. However, it had no effect on these patients’ motivation reduction (P=0/097) and mental fatigue (P=0/080).
Conclusion: Therefore, the cerebellar transcranial direct current stimulation has a beneficial effect on fatigue in MS patients.

کلیدواژه‌ها [English]

  • tDCS
  • Core stability training
  • Multiple Sclerosis
  • Fatigue
  1. Hoffmann S, Vitzthum K, Mache S, Spallek M, Quarcoo D, Groneberg DA, et al. Multiple sklerose: epidemiologie, pathophysiologie, diagnostik und therapie. Praktische Arbeitsmedizin [Internet]. 2009; 17:[12-8 pp.].
  2. Cella D, Dineen K, Arnason B, Reder A, Webster K, Karabatsos G, et al. Validation of the functional assessment of multiple sclerosis quality of life instrument. Neurology. 1996;47(1):129-39.
  3. SOLTANI M, HEJAZI SM, NOORIAN A, ZENDEDEL A, ASHKANIFAR F. The effect of aerobic training on the improvement of expanded disability status scale (EDSS) in multiple sclerosis patients2009.
  4. Cancelli A, Cottone C, Giordani A, Migliore S, Lupoi D, Porcaro C, et al. Personalized, bilateral whole-body somatosensory cortex stimulation to relieve fatigue in multiple sclerosis. Multiple Sclerosis Journal. 2018;24(10):1366-74.
  5. Garg H, Bush S, Gappmaier E. Associations between fatigue and disability, functional mobility, depression, and quality of life in people with multiple sclerosis. International journal of MS care. 2016;18(2):71-7.
  6. Chung LH, Remelius JG, Van RE, Kent-Braun JA. Leg power asymmetry and postural control in women with multiple sclerosis. Medicine and science in sports and exercise. 2008;40(10):1717-24.
  7. Martin CL, Phillips BA, Kilpatrick T, Butzkueven H, Tubridy N, McDonald E, et al. Gait and balance impairment in early multiple sclerosis in the absence of clinical disability. Multiple Sclerosis Journal. 2006;12(5):620-8.
  8. Rougier P, Thoumie P, Cantalloube S, Lamotte D. What compensatory motor strategies do patients with multiple sclerosis develop for balance control? Revue Neurologique. 2007;163(11):1054-64.
  9. Cattaneo D, Jonsdottir J. Sensory impairments in quiet standing in subjects with multiple sclerosis. Multiple Sclerosis Journal. 2009;15(1):59-67.
  10. Kelleher KJ, Spence W, Solomonidis S, Apatsidis D. The characterisation of gait patterns of people with multiple sclerosis. Disability and rehabilitation. 2010;32(15):1242-50.
  11. Aghababa A, Kashi A. The effect of yoga exercises on improving fatigue in women with multiple sclerosis. International Congress on physical education and sports scienses. 2015.
  12. Mokhtarzadeh M, Ranjbar R, Nastaran M. The effect of interval aerobic training on some functional factors, quality of life, fatigue and sleep in women with multiple sclerosis. Daneshvar Medicine. 2016; 24(125):[67- pp.].
  13. Rozgar N, Daneshjoo A, Divkan B. Effect of Eight Weeks of TRX Training on Balance, Fatigue, Muscle Strength, and Speed in Women with Multiple Sclerosis. 2020.
  14. SHARIFI G, MEMARIAN N. EFFECT OF COMBINED TRAININ AND SUPPLEMENT MANESIUMON ENDURANCE AND FATIUE IN PEOPLE WITH MULTIPLE SCLEROSISE. JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS. 2014; 1(1):[- pp.].
  15. Buljevac D, Hop W, Reedeker W, Janssens A, Van der Meche F, Van Doorn P, et al. Self reported stressful life events and exacerbations in multiple sclerosis: prospective study. Bmj. 2003;327(7416):646.
  16. Tofighi A, Saki Y, Razmjoo K. Effect of 12-Week Progressive Resistance Training on Balance, Fatigue and Disability in Women with MS. Jundishapur Scientific Medical Journal. 2013; 12(2):[159-67 pp.].
  17. Ayache SS, Chalah MA. Transcranial direct current stimulation: A glimmer of hope for multiple sclerosis fatigue? Journal of Clinical Neuroscience. 2018;55:10-2.
  18. Charvet LE, Dobbs B, Shaw MT, Bikson M, Datta A, Krupp LB. Remotely supervised transcranial direct current stimulation for the treatment of fatigue in multiple sclerosis: results from a randomized, sham-controlled trial. Multiple Sclerosis Journal. 2018;24(13):1760-9.
  19. Saiote C, Goldschmidt T, Timäus C, Steenwijk MD, Opitz A, Antal A, et al. Impact of transcranial direct current stimulation on fatigue in multiple sclerosis. Restorative neurology and neuroscience. 2014;32(3):423-36.
  20. Ayache SS, Palm U, Chalah MA, Al-Ani T, Brignol A, Abdellaoui M, et al. Prefrontal tDCS decreases pain in patients with multiple sclerosis. Frontiers in neuroscience. 2016;10:147.
  21. Iodice R, Manganelli F, Dubbioso R. The therapeutic use of non-invasive brain stimulation in multiple sclerosis–a review. Restorative Neurology and Neuroscience. 2017;35(5):497-509.
  22. Ghafari S, Ahmadi F, Nabavi SM. Effects of applying hydrotherapy on fatigue in multiple sclerosis patients. Journal of Mazandaran University of Medical Sciences [Internet]. 2008; 18(66):[71-81 pp.].
  23. Boosman H, Visser-Meily JM, Meijer J-WG, Elsinga A, Post MW. Evaluation of change in fatigue, self-efficacy and health-related quality of life, after a group educational intervention programme for persons with neuromuscular diseases or multiple sclerosis: a pilot study. Disability and rehabilitation. 2011;33(8):690-6.
  24. Ashrafi A, Mohseni-Bandpei MA, Seydi M. The effect of tDCS on the fatigue in patients with multiple sclerosis: A systematic review of randomized controlled clinical trials. Journal of Clinical Neuroscience. 2020.
  25. shahrjerdi s, golpayegani m, faraji f, MASOUMI M. Effect of eight weeks Yoga and core stabilization exercises on balance in women with multiple sclerosis 2016.
  26. Folstein MF, Folstein SE, McHugh PR. “Mini-mental state”: a practical method for grading the cognitive state of patients for the clinician. Journal of psychiatric research. 1975;12(3):189-98.
  27. University B. TDCS and TACS Safety Questionnaire Birmingham University. 2015.
  28. Kurtzke JF. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology. 1983;33(11):1444.
  29. Kurtzke JF. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS) 1983 [1444-].
  30. SEYEDIAN M, FALAH M, NOUROUZIAN M, NEJAT S, DELAVAR A, GHASEMZADEH HA. VALIDITY OF THE FARSI VERSION OF MINI-MENTAL STATE EXAMINATION. JOURNAL OF MEDICAL COUNCIL OF IRI [Internet]. 2008; 25(4):[- pp.].
  31. Chehrehgosha M, Dastourpour M, Sanagu A, Mohamadi A. Cancer-related Fatigue and its Relationship with Demographic and Clinical Characteristics. Jorjani Biomedicine Journal [Internet]. 2013; 1(2):[24-31 pp.].
  32. Smets E, Garssen B, Bonke Bd, De Haes J. The Multidimensional Fatigue Inventory (MFI) psychometric qualities of an instrument to assess fatigue. Journal of psychosomatic research. 1995;39(3):315-25.
  33. R. KJ, M. S, A. K, H. S, T R. Different Scales of Fatigue in Traffic Policemen. Journal of Police Medicine [Internet]. 2012; 1(1):[2- pp.].
  34. Yosephi MH, Ehsani F, Zoghi M, Jaberzadeh S. Multi-session anodal tDCS enhances the effects of postural training on balance and postural stability in older adults with high fall risk: primary motor cortex versus cerebellar stimulation. Brain stimulation. 2018;11(6):1239-50.
  35. Chan W, Dobbs B, Shaw M, Kasschau M, Sherman K, Krupp L, et al. Baseline affect predicts improved fatigue with telerehabilitation using remotely-supervised transcranial direct current stimulation (RS-tDCS) in adults with multiple sclerosis (MS)(P3. 343)2017.
  36. Zakibakhsh N, Basharpoor S, Ghalyanchi Langroodi H, Narimani M, Nitsche MA, Salehinejad MA. Repeated prefrontal tDCS for improving mental health and cognitive deficits in multiple sclerosis: A randomized, double-blind, parallel-group study. Journal of translational medicine. 2024;22(1):843.
  37. Muñoz-Paredes I, Herrero AJ, Seco-Calvo J, editors. Influence of Transcranial Direct Current Stimulation and Exercise on Physical Capacity and Gait in Multiple Sclerosis: A Cross-Over Pilot Study. Healthcare; 2023: MDPI.
  38. Jagadish A, Shankaranarayana AM, Natarajan M, Solomon JM. Transcranial direct current stimulation for fatigue in neurological conditions: a systematic scoping review. Physiotherapy research international. 2024;29(1):e2054.
  39. Baldini S, Sartori A, Rossi L, Favero A, Pasquin F, Dinoto A, et al. Fatigue in Multiple Sclerosis: A Resting-State EEG Microstate Study. Brain Topography. 2024;37(6):1203-16.
  40. Hiew S, Nguemeni C, Zeller D. Efficacy of transcranial direct current stimulation in people with multiple sclerosis: a review. European Journal of Neurology. 2022;29(2):648-64.