Medical Journal of Mashhad university of Medical Sciences

Medical Journal of Mashhad university of Medical Sciences

The effects of curcumin on clinical symptoms in Patients with Chronic venous insufficiency: A double-blind clinical trial

Document Type : Research Paper

Authors
Jamal Jalili Shahri 1
Haniye Mahaki 1
Maryam Saberi Karimian 2
Amirhossein Sahebkar 3
Reyhaneh Ahmadi 1
Gholamhossein Kazemzadeh 1
Arezoo Valipoure 1
1 Vascular and Endovascular Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
2 Assistant Professor, Department of Molecular Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
3 ..
10.22038/mjms.2025.27548
Abstract
Introduction: Given its anti-inflammatory, antioxidant, and antithrombotic ProPerties, curcumin may Potentially imProve symPtoms in Patients with ischemia and enhance their quality of life. However, no clinical trials have yet been conducted in this context. The Present study aimed to evaluate the effects of curcumin on clinical symPtom imProvement in Patients with chronic venous insufficiency (CVI).
Methods: This double-blind, randomized clinical trial was conducted in Mashhad in 2023. Patients with CVI (clinical classes 4, 5, and 6) were randomly selected from the Velayat HosPital registry system and invited to ParticiPate. ParticiPants were divided into two grouPs: the intervention grouP received a 500 mg curcumin tablet daily, while the control grouP was given a Placebo tablet. After six weeks, disease imProvement Parameters were comPared between the two grouPs. The collected data were analyzed using SPSS software.
Results: A total of 20 CVI Patients (mean age: 52.60 ± 13.53 years; 75% male, 25% female) were enrolled, with 10 Patients assigned to the curcumin grouP and 10 to the Placebo grouP. No significant differences were observed between the grouPs in terms of sex (P=0.303) or age (P=0.899). Baseline clinical characteristics were also similar between the grouPs. At the end of the study, wound size had decreased in more Patients in the curcumin grouP comPared to the Placebo grouP; however, this difference was not statistically significant (P=0.170).
Conclusion: Based on the findings of this study, curcumin may accelerate wound healing in Patients with chronic venous insufficiency. However, the observed effect was not statistically significant, and further research is needed to establish reliable evidence.
Keywords
Curcumin
Venous Insufficiency
Chronic Wound
Medical Journal of Mashhad university of Medical Sciences
Volume 68, Issue 5
November and December 2025
Pages 1536-1546