1- Mäestu J, Jürimäe J, Jürimäe T. Visfatin and adiponectin levels in children: relationships with physical activity and metabolic parameters. Med Sport Sci. 2010;55:56-68. doi: 10.1159/000321972.
2- Arya R, Duggirala R, Almasy L, Rainwater DL, Mahaney MC, Cole S, Dyer TD, Williams K, Leach RJ, Hixson JE, MacCluer JW, O'Connell P, Stern MP, Blangero J. Linkage of high-density lipoprotein-cholesterol concentrations to a locus on chromosome 9p in Mexican Americans. Nat Genet. 2002 Jan;30(1):102-5. doi: 10.1038/ng810.
3-Yagi S, Kadota M, Aihara K-i, Nishikawa K, Hara T, Ise T, et al. Association of lower limb muscle mass and energy expenditure with visceral fat mass in healthy men. Diabetology & metabolic syndrome. 2014;6(1):27.
4-Bartelt A, Heeren J. Adipose tissue browning and metabolic health. Nature Reviews Endocrinology. 2014;10(1):24.
5-Bi P, Shan T, Liu W, Yue F, Yang X, Liang X-R, et al. Inhibition of Notch signaling promotes browning of white adipose tissue and ameliorates obesity. Nature medicine. 2014;20(8):911.
6-Cohen P, Levy JD, Zhang Y, Frontini A, Kolodin DP, Svensson KJ, et al. Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch. Cell. 2014;156(1-2):304-16.
7-Vosselman MJ, van Marken Lichtenbelt WD, Schrauwen P. Energy dissipation in brown adipose tissue: from mice to men. Molecular and cellular endocrinology. 2013;379(1-2):43-50.
8-Boström P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, et al. A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature. 2012;481(7382):463-8.
9-Weigert C, Lehmann R, Hartwig S, Lehr S. The secretome of the working human skeletal muscle—A promising opportunity to combat the metabolic disaster? PROTEOMICS–Clinical Applications. 2014;8(1-2):5-18.
10-Kazeminasab F, Marandi SM, Ghaedi K, Safaeinejad Z, Esfarjani F, Nasr-Esfahani MH. A comparative study on the effects of high-fat diet and endurance training on the PGC-1α-FNDC5/irisin pathway in obese and nonobese male C57BL/6 mice. Applied Physiology, Nutrition, and Metabolism. 2018;43(7):651-62.
11-Zhang Y, Li J, Huang W, Mo G, Wang L, Zhuo Y, et al. Effect of electroacupuncture combined with treadmill exercise on body weight and expression of PGC-1α, Irisin and AMPK in skeletal muscle of diet-induced obesity rats. Zhen ci yan jiu= Acupuncture research. 2019;44(7):476-80.
12-Gonzalez-Gil AM, Peschard-Franco M, Castillo EC, Gutierrez-DelBosque G, Treviño V, Silva-Platas C, et al. Myokine–adipokine cross-talk: potential mechanisms for the association between plasma irisin and adipokines and cardiometabolic risk factors in Mexican children with obesity and the metabolic syndrome. Diabetology & metabolic syndrome. 2019; 11:1-16.
13-Steinacker JM, Lormes W, Reissnecker S, Liu Y. New aspects of the hormone and cytokine response to training. European journal of applied physiology. 2004; 91:382-91.
14-Rämson R, Jürimäe J, Jürimäe T, Mäestu J. The effect of 4-week training period on plasma neuropeptide Y, leptin and ghrelin responses in male rowers. European journal of applied physiology. 2012;112: 1873-80.
15-Zaccaria M, Ermolao A, Roi G, Englaro P, Tegon G, Varnier M. Leptin reduction after endurance races differing in duration and energy expenditure. European journal of applied physiology. 2002;87: 108-11.
16-Al-Dhabi NA, Valan Arasu M. Quantification of Phytochemicals from Commercial Spirulina Products and Their Antioxidant Activities. Evid Based Complement Alternat Med. 2016;2016:7631864. doi: 10.1155/2016/7631864.
17- Pak W, Takayama F, Mine M, Nakamoto K, Kodo Y, Mankura M, Egashira T, Kawasaki H, Mori A. Anti-oxidative and anti-inflammatory effects of spirulina on rat model of non-alcoholic steatohepatitis. J Clin Biochem Nutr. 2012 Nov;51(3):227-34. doi: 10.3164/jcbn.12-18.
18- Khalafi M, Symonds ME. The impact of high-intensity interval training on inflammatory markers in metabolic disorders: A meta-analysis. Scand J Med Sci Sports. 2020 Nov;30(11):2020-2036. doi: 10.1111/sms.13754.
19- Golestani F, Mogharnasi M, Erfani-Far M, Abtahi-Eivari SH. The effects of spirulina under high-intensity interval training on levels of nesfatin-1, omentin-1, and lipid profiles in overweight and obese females: A randomized, controlled, single-blind trial. J Res Med Sci. 2021 Jan 28;26:10. doi: 10.4103/jrms.JRMS_1317_20.
20- Murawska-Cialowicz E, Wolanski P, Zuwala-Jagiello J, Feito Y, Petr M, Kokstejn J, Stastny P, Goliński D. Effect of HIIT with Tabata Protocol on Serum Irisin, Physical Performance, and Body Composition in Men. Int J Environ Res Public Health. 2020 May 20;17(10):3589. doi: 10.3390/ijerph17103589.
21-Villareal DT, Aguirre L, Gurney AB, Waters DL, Sinacore DR, Colombo E, et al. Aerobic or resistance exercise, or both, in dieting obese older adults. New England Journal of Medicine. 2017;376(20):1943-55.
22- Gilgen-Ammann R, Schweizer T, Wyss T. RR interval signal quality of a heart rate monitor and an ECG Holter at rest and during exercise. Eur J Appl Physiol. 2019 Jul;119(7):1525-1532. doi: 10.1007/s00421-019-04142-5.
23-Eskandari M, Pournemati P, Hooshmand Moghadam B, norouzi j. The Interactive Effect of Aerobic Exercise and Supplementation of Blue-Algae (Spirulina) on Anthropometric Indexes and Cardiovascular Risk Factors in Diabetic Men. Sadra Medical Journal. 2019;8(1):51-62.
24- Guo M, Yao J, Li J, Zhang J, Wang D, Zuo H, et al. Irisin ameliorates age‐associated sarcopenia and metabolic dysfunction. Journal of cachexia, sarcopenia and muscle. 2023;14(1):391-405.
25-Mohammad M, Karim D, Mehdi M, Marziyeh S, Hadi S, Shila N. The combinatory effect of spirulina supplementation and resistance exercise on plasma contents of adipolin, apelin, ghrelin, and glucose in overweight and obese men. Mediators of Inflammation. 2022;2022(1):9539286.
26-Irfan A, Said SF, Siddique S, Farooq MH, Mubarak S, Latif S, et al. Synergistic Effects of Moringa Oleifera with Metformin in Improving Glycemic Control in Type 2 Diabetics through a Randomized Controlled Trial. Journal of Herbal Medicine. 2025:101029.
27- Delfan M, Saeidi A, Supriya R, Escobar KA, Laher I, Heinrich KM, Weiss K, Knechtle B, Zouhal H. Enhancing cardiometabolic health: unveiling the synergistic effects of high-intensity interval training with spirulina supplementation on selected adipokines, insulin resistance, and anthropometric indices in obese males. Nutr Metab (Lond). 2024 Mar 7;21(1):11. doi: 10.1186/s12986-024-00785-0.
28-Hernández-Lepe MA, López-Díaz JA, Juárez-Oropeza MA, Hernández-Torres RP, Wall-Medrano A, Ramos-Jiménez A. Effect of Arthrospira (Spirulina) maxima supplementation and a systematic physical exercise program on the body composition and cardiorespiratory fitness of overweight or obese subjects: a double-blind, randomized, and crossovercontrolled trial. Marine drugs. 2018;16(10):364.
29-Palacios‐González B, Vadillo‐Ortega F, Polo‐Oteyza E, Sánchez T, Ancira‐Moreno M, Romero‐Hidalgo S, et al. Irisin levels before and after physical activity among school‐age children with different BMI: A direct relation with leptin. Obesity. 2015;23(4):729-32.
30-Vernochet C, Mourier A, Bezy O, Macotela Y, Boucher J, Rardin MJ, et al. Adipose-specific deletion of TFAM increases mitochondrial oxidation and protects mice against obesity and insulin resistance. Cell metabolism. 2012;16(6):765-76.
31-Kim J, Wessling-Resnick M. Iron and mechanisms of emotional behavior. The Journal of nutritional biochemistry. 2014;25(11):1101-7.
32-Wang W, Zheng F, Zhou J, Cao Y, Zhang L, Lu Y, et al. Effects of Aerobic Exercise on Irisin and Skeletal Muscle Autophagy in ApoE−/− Mice. Current Issues in Molecular Biology. 2025;47(5):371.
33-Gorska-Ciebiada M, Ciebiada M. Association between serum Irisin and leptin levels and risk of depressive symptoms in the diabetic elderly population. Journal of Clinical Medicine. 2023;12(13):4283.
34-Algul S, Ozdenk C, Ozcelik O. Variations in leptin, nesfatin-1 and irisin levels induced by aerobic exercise in young trained and untrained male subjects. Biology of sport. 2017;34(4):339-44.
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