A Comparative Study on the Urine Level of Albumin in Hypertensive Women in Three Groups of Premenopasal, Post Menopauusal and Hystrectomic

Document Type : Research Paper

Authors

1 Associated Professor of cardiovascular, cardiovascular Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

2 Associate Professor of Biostatistics, Mashhad University of Medical Sciences, Mashhad, Iran

3 General Physician, Mashhad University of Medical Sciences, Mashhad, Iran

4 Pharmacology Student, Mashhad University of Medical Sciences, Mashhad, Iran

5 BSc in Microbiology, cardiovascular, cardiovascular Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

6 MSc in Biochemistry, Mashhad Islamic Azad University, Mashhad Branch, Mashhad, Iran

Abstract

Introduction
Hypertension has a high incidence and has several complications. Many studies have been done to reduce these complications. In recent years one of the important factors in hypertensive patients has been albuminuria. Essential hypertension produces clinical proteinuria and a significant reduction in renal function in many patients. The advent of more sensitive method to quantifies the urinary albumin extraction has revealed higher frequency of micro-albuminuria in patients with hypertension than in normotensive population. This wide variability in the incidence of micro-albuminuria in these studies may be related to the severity of hypertension, selection criteria, racial difference and, in some cases, to smaller number of patients studied. It can be different in men and women and also in separate periods of sexual hormone function in women.
Materials and Methods
Three groups of hypertensive women including premenopausal, postmenopausal and hysterectomic referred to Ghaem hospital were selected. Sample size was 125 (for premenopausal 50, postmenopausal 50 and hysterectomic 25). Morning urine analysis of albumin was done by ELISA test.
Results
Mean age was 50.1±10.24 years old. Mean duration of hypertension was 6.6±4.78 years. Mean level of albuminuria was 20.72±21.89. There was no significant difference between three groups for albuminuria (p=0.081), but there was a statistical difference between premenopausal and hysterectomic patients (p<0.001).
Conclusion
It could be said that lack of sexual hormones may be influential for increasing of albuminuria.

Keywords

Medical Journal of Mashhad university of Medical Sciences
Volume 56, Issue 3 - Serial Number 3
July and August 2013
Pages 170-176

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