Effect of 12-week resistance training on Mafa expression in pancreas tissue and serum insulin in type 2 diabetic rats

Document Type : Research Paper


1 Department of Physical Education and Sport Sciences, Ghaemshahr Branch, Islamic Azad University, Ghaemshahr, Iran

2 Assistant Professor, Department of Physical Education and Sport Sciences, Ghaemshahr Branch, Islamic Azad University, Ghaemshahr, Iran


Introduction: Increased Mafa expression with increased insulin secretion from pancreatic beta cells and consequent improvement in glycemic profile in type 2 diabetic patients. This study aimed to determine the effect of resistance on Mafa expression in pancreas tissue, glucose and insulin in type 2 diabetes rats.
Material and Methods: The statistical population consisted of all male Wistar rats of the pastor inistitue of Iran, among which 14 were male rat 10 weeks old weighting 220 ± 20 g. Type 2 diabetes induced by Intraperitoneal injection of nicotinamid + STZ. Then rats divided randomly into resistance (6 weeks, 5 times/weekly, n=7) and control (n=7) groups. Fasting glucose, serum insulin and Mafa expression in Pancreas tissue of both groups were measured after lasted exercise and compared between 2 groups by independent T test.
Results: Resistance training significantly reduced fasting glucose and significantly increased serum insulin levels compared with the control group. Resistance training also increased Mafa expression in pancreatic tissue( p>0/0001).
Conclusion: Based on these data, increased serum insulin in response to resistance training in T2D rats may be attributed with increased Mafa expression in pancreas tissue.


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