Effect of Stevia Consumption and Aerobic Exercise on Fat Profile and Insulin Resistance in Type 2 Diabetic men

Document Type : Research Paper


1 Department of Physical Education and Sport Sciences, East Tehran Branch, Islamic Azad University, Tehran, Iran.

2 Department of physical education & sport science, Faculty of Humanities, East Tehran Branch, Islamic Azad University, Tehran, Iran


Introduction: Aerobic exercises along with the use of herbal supplements are an effective way to control the complications of diabetes. The aim of this study was to study the effect of Stevia Oral consumption and aerobic exercise on fat profile and insulin resistance in type 2 diabetic men.
Methods: In this study, 28 men with type 2 diabetes were selected for purposeful and randomly divided into 4 groups of 7, Including aerobic exercise group, stevia consumption group, aerobic exercise group + stevia consumption and control group were divided. The exercise protocol was conducted for 8 weeks and 3 sessions each week, each session being 20-45 minutes. The outcome data was analyzed using Dependent T-test and Analyze of Covariance.
Result: There was  a significant difference between the level of pre-test and post-test of HDL, LDL, cholesterol, fasting blood glucose, triglyceride, insulin resistance, insulin resistance and maximum oxygen in the two groups of aerobic exercise and aerobic exercise + Stevia supplements compared to the two groups of Stevia supplements and control (P≤0.05) LDL, cholesterol, fasting blood glucose, triglyceride, insulin, Insulin resistance, decreased and HDL and maximal oxygen levels increased (P≤0.05).
Conclusions: According to research, aerobic exercise appears to decrease cholesterol, insulin resistance, fasting blood sugar and triglycerides, but intake stevia supplements has little effect on related variables.


  1. Riyahi Malayeri S, Azadniya A, Rasaee M J. Effect of eight-week High intensity interval training nd resveratrol
    intake on serum adiponectin and resistin in type 2 diabetic rats. Ijdld 2019; 18 (1) :8-1.
    2. Tashaorizadeh, Mahla; Mogharnasi, Mehdi. The effect of ten weeks of resistance training on HSP07 and insulin
    resistance in type 2 diabetic women. Sport Biosciences 2016; 8 (3): 341-351.
    3. Riyahi Malayeri S, Abdolhay S, Behdari R, Hoseini M. The combined effect of resveratrol supplement and
    endurance training on IL-10 and TNF- α in type 2 diabetic rats. RJMS. 2019; 25 (12) :140-149.
    4. Zaman J, Kumar S, Khunti K, Hanif W. Position statement on diagnosis and treatment of obesity in British
    south Asians 2009.
    5. Hashemi, Mahsa Sadat. Stevia sweetener and its effect on diabetic patients, Iranian Journal of Diabetes and
    Lipid, National Conference on Food Safety. Islamic Azad University of Savadkoh Branch 2013;.221.
    6. Maki KC1, McKenney JM, Farmer MV, Reeves MS, Dicklin MR. Indices of insulin sensitivity and secretion
    from a standard liquid meal test in subjects with type 2 diabetes, impaired or normal fasting glucose. Diabetes
    Technology & Therapeutics 2009 . 28;8:22
    7. Sharma R, Yadav R, Manivannan E. Study of effect of Stevia rebaudiana bertoni on oxidative stress in type-2
    diabetic rat models. Biomed Aging Pathol 2012; 2:126–131.
    8. Boulé NG, Haddad E, Kenny GP, Wells GA, Sigal RJ. Effects of exercise on glycemic control and body mass
    in type 2 diabetes mellitus: a meta-analysis of controlled clinical trials. JAMA 2001 Sep 12;286(10):1218-27.
    9. Rashidelmir, Amir; Alizadeh, Akram; Ebrahim Atri, Ahmad; The effect of 4 weeks of aerobic training with
    cinnamon on lipoprotein and blood glucose in type 2 diabetic women. Shahid Sadoughi University of Medical
    Sciences Journal of Yazd 2012;20 (5): 614-605.
    10. Sigal RJ, Kenny GP, Boule NG, et al. Effects of aerobic training, resistance train-ing, or both on glycemic
    control in type 2 diabetes: A randomized trial. Ann Intern Med 2007; 147:357–69
    11. Massi-Benedetti M, Herz M, Pfeiffer C. The effects of acute exercise on metabolic control in type II diabetic
    patients treated with glimepiride or glibenclamide. Horm Metab Res 1996 Sep;28(9):451-5. PubMed PMID:
    12. Bravata DM, Wells CK, Concato J, Kernan WN, Brass LM, Gulanski BI. Two measures of insulin sensitivity
    provided similar information in a U.S. population. J Clin Epidemiol 2004 Nov;57(11):1214-7.
    13. Cauza E, Hanusch-Enserer U, Strasser B, Ludvik B, Metz-Schimmerl S, Pacini G, Wagner O, Georg P, Prager
    R, Kostner K, Dunky A, Haber P. The relative benefits of endurance and strength training on the metabolic factors
    and muscle function of people with type 2 diabetes mellitus. Arch Phys Med Rehabil 2005 Aug;86(8):1527-33.
    14. Esfahani M. Effects of aerobic exercise on blood glucose control, cardiovascular fitness-breathing and risk
    factors associated with heart disease-vascular diseases in diabetic patients with mild and severe insulin
    independent. Olympic J 2006 36:124-9 .
  2. 15.Gregersen S, Jeppesen PB, Holst JJ, Hermansen K. Antihyperglycemic effects of stevioside in type 2 diabetic
    subjects. Metabolism 2004 Jan;53(1):73-6.
    16.Teymouri, Abzar-Rahmani Nia, Farhad-Mirzaei, Bahman-Tajbakhsh, Ramin. Comparison of the effects of
    aerobic exercise and orlistat on insulin resistance and lipid profile in obese men, Journal of Metabolism and
    Exercise 2016; 6 (2): 137-152.
    17. Saedmocheshi S, Saedmocheshi L, Almori M R, Ghafari G. The effects of regular aerobic training and grape
    seed extract on the cardiovascular risk factors in obese older women. Scientific Journal of Kurdistan University of
    Medical Sciences 2015; 20 (3) :69-78
    18.Khajavi Mary, Bizheh Venus, moazzami moonlight. The effect of twelve weeks of aerobic training on serum
    lipid profile, aerobic power and body composition of non-athletic mentally retarded girls. Shahrekord University
    of Medical Sciences Journal 2014; 1 (1): 1-3
    19. Rezanezhad, Reza; Badli, Habib. Using Stevia Sugar as an Approach to Achieve More Health and Control of
    Diabetes. 4th International Conference on New Findings in Science and Technology, Qom, Soroush Hekmat
    Mortazavi Islamic Studies and Research Center 2016; 1-5.
    20. Kodama S, Tanaka S, Saito K, Shu M, Sone Y, Onitake F, Suzuki E, Shimano H, Yamamoto S, Kondo K,
    Ohashi Y, Yamada N, Sone H. Effect of aerobic exercise training on serum levels of high-density lipoprotein
    cholesterol: a meta-analysis. Arch Intern Med 2007 May 28;167(10):999-1008. PubMed PMID: 17533202.
    21. Guan, X. M., Wu, S. L., Yang, X. L., Han, X., Yang, Y. H., Li, X. T & Li, H. H. Association of total cholesterol,
    low‐density lipoprotein cholesterol, and non‐high‐density lipoprotein cholesterol with atherosclerotic
    cardiovascular disease and cancer in a Chinese male population. International journal of cancer 2018; 142(6):1209-
    22. Na, C. I., Kim, D., Lee, H., Jung, H., Jung, J., Kim, H., & Baek, C. Effect of the pilates exercise on the health
    physical fitness, immunoglobulin and sex hormone in female college students. The FASEB Journal 2010; 24(1):
    23. Marinda F, Magda G, Ina S, Brandon S, Abel T, Ter Goon D. Effects of a mat pilates program on
    cardiometabolic parameters in elderly women. Pak J Med Sci 2013 Apr;29(2):500-4. PubMed PMID: 24353564;
    PubMed Central PMCID: PMC3809231.
    24. Mawi M.. Effect of aerobic exercise on blood lipid levels in postmenopausal women. Physiology Department,
    Medical Faculty, Trisakti University. Univ Med 2009; 28: 17-24
    25. Gateva A, Assyov Y, Tsakova A, Kamenov Z. Classical (adiponectin, leptin, resistin) and new (chemerin,
    vaspin, omentin) adipocytokines in patients with prediabetes. Horm Mol Biol Clin Investig 2018 Jan 15;34(1). pii:
    /j/hmbci.2018.34.issue-1/hmbci-2017-0031/hmbci-2017-0031.xml. doi: 10.1515/hmbci-2017-0031. PubMed
    PMID: 29332012.
    26. Krist J, Wieder K, Klöting N, Oberbach A, Kralisch S, Wiesner T, Schön MR, Gärtner D, Dietrich A, Shang
    E, Lohmann T, Dreßler M, Fasshauer M, Stumvoll M, Blüher M. Effects of weight loss and exercise on apelin
    serum concentrations and adipose tissue expression in human obesity. Obes Facts 2013;6(1):57-69. doi:
    10.1159/000348667. Epub 2013 Feb 21. PubMed PMID: 23429279; PubMed Central PMCID: PMC5644751.
    27.Kadoglou NP, Vrabas IS, Kapelouzou A, Lampropoulos S, Sailer N, Kostakis A, Liapis CD, Angelopoulou N.
    The impact of aerobic exercise training on novel adipokines, apelin and ghrelin, in patients with type 2 diabetes.
    Med Sci Monit 2012 May;18(5):CR290-5. PubMed PMID: 22534708; PubMed Central PMCID: PMC3560628.
    28.Baharlou Somayeh, Taqian Farzaneh, Hedayat Mehdi. The effect of aerobic training on glucose, insulin and
    insulin resistance in overweight-obese women with subclinical hypothyroidism. Razi Journal of Medical Sciences
    2014; 1 (1): 1-3. (Persian)
    29. Kazemi, Nasibi-Kurdi Mohammad Reza, Nuri Reza-Kasraian, Maryam. The effect of two types of aerobic and
    resistance training programs on fasting blood glucose and insulin levels in gestational diabetes mellitus women,
    Yasuj University of Medical Sciences 2016 21 (3): 249-264. (Persian)
    30. Yar Ahmadi, Hadi-Haghighi, Amir Hossein-Shojaee, Maliheh-Beheshti Nasr, Seyed Mehdi. The effect of a
    period of aerobic training on appetite and insulin resistance in obese women. Knowledge Horizon Journal 2014.1
    31. Saremi, Abbas. Exercise and diabetes mellitus type 2: A review of the evidence. Cell and Tissue Journal 2011;
    2 (3):171-181.