Evaluation of serum homocysteine levels with coronary artery disease in angiographic patients

Document Type : Research Paper

Authors

1 Postdoctoral Student, UNESCO International Center for Basic Sciences Related to Human Health and Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.

2 Assistant Professor of Community Medicine, Clinical Research Development Unit, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran

3 Student Research Committee, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

4 Professor, Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Postdoctoral Student, UNESCO International Center for Basic Sciences Related to Human Health and Nutrition, Mashhad

5 Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Abstract

Introduction: Cardiovascular disease is estimated the cause of 17.3 million deaths annually in the world and 27.4% of deaths in Iran. Since the common risk factors cannot currently predict all causes of cardiovascular disease, researchers have suggested that other factors such as oxidative stress, trace elements, inflammation, and homocysteine may be potential contributors to cardiovascular disease. Therefore, in this study, we assess the association of serum level of homocysteine with the severity of coronary artery involvement.
Material and Methods: In this cross-sectional study, 347 patients referred to Ghaem Hospital for angiography and 103 healthy individuals without cardiac symptoms were evaluated. Subjects were divided into five groups with more than 50% stenosis of one (1), two (2), and three (3) arteries, individuals with normal angiography or less than 50% involvement (4), and healthy subjects (5). Serum homocysteine level was measured by ELISA at Bou-ali Research Institute. Statistical data analysis was performed using SPSS software version 21.
Results: In this research, 106 healthy people, 91 normal people, and 80, 87, and 89 people with stenosis in one, two, and three arteries, respectively were studied. The mean homocysteine in the groups with stenosis of one, two, and three vessels was significantly higher than the normal and healthy groups (P <0.001). The results of logistic regression analysis showed that increment of one unit of homocysteine raised the chance of vascular involvement in people with one, two, and three-vessel involvement into 1.235 (1. 053-1. 273), 1.289 (1.125-1.414), 1.461 (1.326-1.611), respectively (P <0.001)
Conclusion: The results of the present study showed that increase in concentration of homocysteine as an independent risk factor can lead to greater prevalence and progression of vascular stenosis.

Keywords

References

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medical journal of mashhad university of medical sciences
Volume 64, Issue 2
July and August 2021
Pages 2763-2774

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