Medical Journal of Mashhad university of Medical Sciences

Medical Journal of Mashhad university of Medical Sciences

The Investigate of Effect Eight Weeks of Combined Exercise on P3NP, CAF and IGF-1 on CABG Patients

Document Type : Research Paper

Authors
Sahar Alaei 1
Amir Rashidlamir 2
Rambod Khajei 1
Ameneh Barjaste yazdi 1
1 Department of Physical Education, Neyshabour Branch, Islamic Azad University, Neyshabour, Iran
2 Department of Exercise Physiology, Faculty of Sport Sciences, Ferdowsi University of Mashhad, Mashhad, Iran
10.22038/mjms.2021.18785
Abstract
Introduction
This study aimed to investigate the effect of eight weeks of combined exercise on P3NP, CAF and some sarcomopia factors in CABG patients.
Materials and Methods
24 CABG middle-aged men participated in this study. Then the participants were randomly divided into two groups of 12-person combination exercise (mean age 54.58 ±6.47 years) and control group (mean age 50.70 ±7.70 years). Anthropometric indices and serum P3NP, CAF and IGF-1 blood parameters were prepared and analyzed before and after training. The eight-week combined exercise program was conducted in three sessions with the supervision of cardiac rehabilitation specialists. Repeated measures statistical test was used for data analysis.
Results
Combined exercise was associated with a significant decrease in serum P3NP levels (p=0.001), but these changes were not significant compared to the control group (p=0.334). But these changes were not significant compared to the control group (p=0.334). There was also a significant increase in serum CAF levels in the post-test compared to the pre-test (p=0.02) and the differences between the control group and the training group were significant (p=0.038). On the other hand, a significant increase in serum IGF-1 levels was observed in the post-test compared to the pre-test (p=0.001), but the serum levels of IGF-1 were not significant in the control group (p=0.280).
Conclusion
A short-term combination training in CABG patients increased IGF-1 and CAF, but no change in P3NF levels. Further research is needed to investigate the effect of combined exercise on CAGB patients on these indices.
Keywords
Coronary artery bypass grafting
Amino terminal levels of type III procollagen
C-Agrin terminus fragment
Combined exercise
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Medical Journal of Mashhad university of Medical Sciences
Volume 64, Issue 3
September and October 2021
Pages 3103-3116