Medical Journal of Mashhad university of Medical Sciences

Medical Journal of Mashhad university of Medical Sciences

A Case Report of Nodular Regenerative Hyperplasia

Document Type : Research Paper

Authors
Ahmad Khosravi 1
Tahereh Fakharian 2
Kamran Ghafarzadegan 3
Masoud Pezeshky Rad 4
1 Associate professor of Internal Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2 - Fellow of Gastroenterology, Mashhad University of Medical Sciences, Mashhad, Iran
3 Clinical pathologist, Mashhad University of Medical Sciences, Mashhad, Iran
4 - Associate professor of Interventional Radiology, Mashhad University of Medical Sciences, Mashhad, Iran
10.22038/mjms.2012.192
Abstract
Introduction
Nodular regenerative hyperplasia is a rare cause of portal hypertension. Clinical findings are consist of complication of portal hypertension such as variceal bleeding. Histopathology is key of diagnosis.
Case report
Patient was a 44 years old woman with a chief complaint of flank pain and easy bruising. She had a history of hematemesis many years ago. In physical examination, she had huge splenomegaly and ecchymoses on lower extrimities. Lab data are normal except for pancytopenia. In upper endoscopy, esophageal varices and portal hypertensive gastropathy were seen. Subsequently, she was found to have nodular regenerative hyperplasia on liver biopsy. Esophageal varices banded successfully and she was asymptomatic on Beta blocker after wards.
Conclusion
 Nodular regenerative hyperplasia should be considered in the differential diagnosis of any patient with portal hypertension without cirrhosis.
Keywords
Liver
Nodular regenerative hyperplasia
Portal Hypertension
Medical Journal of Mashhad university of Medical Sciences
Volume 55, Issue 4 - Serial Number 4
January 2013
Pages 250-254