Medical Journal of Mashhad university of Medical Sciences

Medical Journal of Mashhad university of Medical Sciences

Frequency of latent tuberculosis infection between age groups in family members of a patient with a pulmonary tuberculosis in Iran

Document Type : Research Paper

Authors
Roxana Mansour Ghanaie 1
Arash Mohazzab 2
Mahshid Nasehi 3
Mansour Naseri Hersini 4
Leila Azimi 1
Aliakbar Rajabloo 5
Amir Bazzi Shad 6
Seyedeh Mahsan Hoseinialfatemi 7
1 Pediatric Infections Research Center , Research Institute for Children’s Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2 Department of Epidemiology, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
3 Center for Communicable Diseases Control, Ministry of Health and Medical Education, Tehran, Iran.
4 Department of immunology, School of public health, Tehran university of medical science, Tehran, Iran.
5 Central Laboratory of deputy of health, Golestan university of medical sciences. Gorgan, Iran
6 Deputy of health, Zabol university of medical science, Zabol, Iran
7 Pediatric Infections Research Center, Research Institute for Children’s Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran
10.22038/mjms.2022.20132
Abstract
Background: Given that tuberculosis infection is present in one-quarter of the world's population and is more likely to convert to tuberculosis, especially at a young age, its diagnosis and prevention is an important part of the World Health Organization's (WHO) program. The aim of this study is to evaluate the frequency of latent tuberculosis infection (LTBI) in different age groups of family members of pulmonary tuberculosis patients in two provinces of Iran with a high prevalence of tuberculosis during 18 months.
Method: Family members of confirmed pulmonary tuberculosis patients were followed up as a retrospective and prospective study in the cities of Gorgan and Zabol at 0, 3, 12 and 18 months after the starting the study. LTBI was diagnosed by using the QuantiFERON test kit and the Tuberculin skin test (TST).
Results: The number of LTBI cases based on QFT or TST was 354 (52.99%) in the whole study and 33.33% in children under 5 years old. Positive cases of TST, QFT and LTBI in the age group over 18 years were significantly different with 5 to 18 years and less than 5 years, while there was no significant difference between the age groups of less than 5 years and 5 to 18 years.
Conclusion: The results of this study showed that most cases of infection occur before the diagnosis of the index case or in the first phase of study, and there is no significant difference between the diagnosis with TST or QFT.
Keywords
Tuberculin Test
Pulmonary Tuberculosis
Latent Tuberculosis
Frequency
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Medical Journal of Mashhad university of Medical Sciences
Volume 65, Issue 1
May and June 2022
Pages 1-11