Methods of viral diseases diagnosis based on biosensors

Document Type : Review article


1 University of Tehran, Faculty of New Sciences and Technologies, Life Science Engineering department

2 Life Science Engineering department, Faculty of New Sciences and Technologies, University of Tehran


The recent events of outbreaks related to different viruses in the past few years, increased exponentially by the pandemic caused by the coronavirus disease 2019 (COVID-19), raised a concern and increased the search for more information on viruses-based diseases. Currently, the detection of viruses using methods based on polymerase chain reaction (PCR) has the highest sensitivity. However, this method has its drawbacks. Research of biosensors is also becoming the most extensively studied discipline because of the easy, rapid, low-cost, highly sensitive, and highly selective biosensors contribute to advances in next-generation medicines. Thus, biosensors represent a new promising tool for virus detection. This review gives a brief survey of the issue of viral detection, comprising diagnostics of a target structure of viruses, such as nucleic acids or proteins. This article reviews the different principles of detection and manufacturing methods for each type of virus biosensors and finally introduces some of their applications in virus diagnosis, expanding compared to conventional methods.


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