Quality of Life in 8-12-year-old Children with Asthma in Karaj

Document Type : Research Paper


1 Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran

2 Department of allergy and Clinical Immunology, Mofid Children’s Hospital, Shaheed Beheshti University Of Medical Sciences, Tehran, Iran

3 Student Research Committee, Alborz University of Medical Sciences, Karaj, Iran.

4 Department of Healthcare Services Management, School of Health and Research Center for Health, Safety and Environment, Alborz University of Medical Sciences, Karaj, Iran.

5 Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran Department of Epidemiology and Biostatistics, School of Health and, Alborz University of Medical Sciences, Karaj, Iran.

6 Department of Immunology, School of Medicine and Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.


Background and Aim: Asthma is the most common chronic respiratory disease in children. Most of the asthmatic patients are considered mild; however, 5-10% of patients suffer from severe disease Asthma has a considerable impact on patients' quality of life, especially among severe asthmatic patients. This study was designed to evaluate the quality of life in 8-12-year-old asthmatic patients.
Materials and Methods: A cross-sectional study was conducted in 2017-2018 using the Persian version of PedsQLTM 4,0 questionnaire. A total of 140 asthmatic patients who referred to allergy clinic in Karaj , were diagnosed by an allergist with 140 healthy children as the control group were enrolled.
Results: More than half of the patients and control group were boys (n=85; 58.6%). The mean total score of PedsQLTM 4,0 in the asthmatic group was 23.11 (SD=15.60) comparing to 8.96 (SD=9.89) in the control group (P<0.001). All different aspects of quality of life; physical performance, social function, emotional performance, and performance in school were significantly lower in asthmatic group. The quality of life score was considerably lower in patients with a history of hospital admission and patients with high steps of asthma severity (P<0.05). There was no significant difference in the score of PedsQLTM 4,0 between girls and boys (P>0.05).
Conclusion: Asthma has a significantly adverse effect on different aspects of children's quality of life including physical performance, social function, emotional performance and performance in school in Karaj city.


  1. Elnady HG, Sherif LS, Sabry RN, Zeid DA, Atta H, Hassanain AI, et al. Relation of Asthma
    Control with Quality of Life among a Sample of Egyptian Asthmatic School Children. Open
    Access Macedonian Journal of Medical Sciences. 2019;7(17):2780.
    2. EntezariA, Mehrabi Y, Varesvazirian M, Pourpak Z, Moin M. A systematic review of recent
    asthma symptom surveys in Iranian children. Chronic respiratory disease. 2009;6(2):109-14.
    3. Deraz T, Kamel TB, El‐Kerdany TA, El‐Ghazoly HM. High‐sensitivity C reactive protein as a
    biomarker for grading of childhood asthma in relation to clinical classification, induced sputum
    cellularity, and spirometry. Pediatric pulmonology. 2012;47(3):220-5.
    4. Pawankar R, Canonica GW, Holgate ST, Lockey RF. Allergic diseases and asthma: a major
    global health concern. Current opinion in allergy and clinical immunology. 2012;12(1):39-41.
    5. Chan KS, Mangione-Smith R, Burwinkle TM, Rosen M, Varni JW. The PedsQL™: Reliability
    and validity of the short-form generic core scales and asthma module. Medical care. 2005:256-
    6. Upton P, Lawford J, Eiser C. Parent–child agreement across child health-related quality of life
    instruments: a review of the literature. Quality of life research. 2008;17(6):895.
    7. Roncada C, Mattiello R, Pitrez PM, Sarria EE. Specific instruments to assess quality of life in
    children and adolescents with asthma. Jornal de Pediatria (Versão em Português).
    8. Gheissari A, Farajzadegan Z, Heidary M, Salehi F, Masaeli A, Mazrooei A, et al. Validation of
    persian version of PedsQL™ 4.0™ generic core scales in toddlers and children. International
    journal of preventive medicine. 2012;3(5):341.
    9. Thissen D, Varni JW, Stucky BD, Liu Y, Irwin DE, DeWalt DA. Using the PedsQL™ 3.0
    asthma module to obtain scores comparable with those of the PROMIS pediatric asthma impact
    scale (PAIS). Quality of Life Research. 2011;20(9):1497-505.
    10. Varni JW, Burwinkle TM, Rapoff MA, Kamps JL, Olson N. The PedsQL™ in pediatric asthma:
    reliability and validity of the PediatricQuality of Life Inventory™ generic core scales and
    asthma module. Journal of behavioral medicine. 2004;27(3):297-318.
    11. Sritipsukho P, Satdhabudha A, Nanthapisal S. Effect of allergic rhinitis and asthma on the
    quality of life in young Thai adolescents .Asian Pac J Allergy Immunol. 2015;33(3):222-6.
    12. Salman-Yazdi N, Ghasemi I, Salahshourian A, Haghani H. Comparative study on the quality of
    life amongst asthmatic boys and girls aged between 7-17 in Zanjan. Iranian Journal of
    Cardiovascular Nursing. 2.24-9:)1(1;012
    13. Jafari P, Forouzandeh E, Bagheri Z, Karamizadeh Z, Shalileh K. Health related quality of life of
    Iranian children with type 1 diabetes: reliability and validity of the Persian version of the
    PedsQL™ Generic Core Scales and Diabetes Module. Health and quality of life outcomes.
    14. Bousquet J, Knani J, Dhivert H, Richard A, Chicoye A, Ware Jr JE, et al. Quality of life in
    asthma. I. Internal consistency and validity of the SF-36 questionnaire. American journal of
    respiratory and critical care medicine. 1994;149(2):371-5.
    15. Williams B, Powell A, Hoskins G, Neville R. Exploring and explaining low participation in
    physical activity among children and young people with asthma: a review. BMC family practice.
    16. Meszaros A, Orosz M, Magyar P, Mesko A, Vincze Z. Evaluation of asthma knowledge and
    quality of life in Hungarian asthmatics. Allergy. 2003;58(7):624-8.
    17. Akinbami LJ. The state of childhood asthma; United States, 1980-2005. 2006.
    18. Kohen DE. Asthma and school functioning. Health reports. 2010;21(4):35.
    19. Basu D. Quality-of-life issues in mental health care: Past, present, and future. German Journal of
    Psychiatry. 2004;7(3):35-43.
    20. Elis K, Maria G, Stefanos P. Quality of life of Children with Chronic Illnesses. Procedia Soc
    Behav Sci. 2010;2:4763-7.
    21. Juniper EF, Guyatt GH, Ferrie PJ, Griffith LE. Measuring quality of life in asthma. American
    Review of Respiratory Disease. 1993;147:832.
  2. 22. Khoshkhui M, Jafari P, Afrasiabi M, Orooj M, Kashef S .Level of Agreement between Children
    with Asthma and their Parents on Quality of Life. Iranian journal of medical sciences.
    23. Kouzegaran S, Samimi P, Ahanchian H, Khoshkhui M, Behmanesh F. Quality of life in children
    with asthma versus healthy children. Open access Macedonian journal of medical sciences.
    24. Matsunaga NY, Ribeiro MAGdO, Saad IAB, Morcillo AM, Ribeiro JD, Toro AADC. Evaluation
    of quality of life according to asthma control and asthma severity in children and adolescents.
    Jornal Brasileiro de Pneumologia. 2015;41(6):502-8.
    25. Guilbert TW, Garris C, Jhingran P, Bonafede M, Tomaszewski KJ, Bonus T, et al. Asthma that
    is not well-controlled is associated with increased healthcare utilization and decreased quality of
    life. Journal of Asthma. 2011;48(2):126-32.
    26. Miadich SA, Everhart RS, Borschuk AP, Winter MA, Fiese BH. Quality of life in children with
    asthma: a developmental perspective. Journal of pediatric psychology. 2015;40(7):672-9.