Introduction: Osteoporosis is the most common metabolic bone disease and its prominent feature includes loss of total bone matrix mineral. This phenomenon involves more than half of the women population over 50 years old. This study aims to determine the osteoporosis frequency in the first 5 –year period of time in healthy women after menopauses in Rheumatologic Outpatients Clinic in Imam Reza Hospital Medical Center.
Material and methods: In this descriptive cross- sectional study in the year 2010-2012, two hundred and fifty   healthy post- menopausal women were entered to this project with respect to the inclusion and exclusion criteria through target based sampling method. Bone Mineral Densitometry (BMD) was performed in two different regions, femur and lumbar spine (L2-L4). Data was coded and analyzed with Version 17 SPSS Software.
Results: In this study, two hundred and fifty women were evaluated. Their age was between 44 and 62 years old with the average age of 77/3±9/52 years. The mean menopausal period of time and the mean body weight was 2.8±1.5 years and 70±11.55 Kg respectively. Femoral BMD results showed osteopenia in 40% and osteoporosis in 8% of women. However in Lumbar BMD, 44% of our population had osteopenia and 17% were affected with osteoporosis. 
Conclusion: Seventy percent of this study individual (healthy women during their first 5- year of menopauses) had been affected with osteopenia or osteoporosis at least in one region either femur or lumbar spine BMD, however, only 30% of them had normal BMD.