The present study was conducted to investigate the effectiveness of mindfulness skills training on depression and social health of women with depression. The present study was quasi-experimental with pretest, posttest, control group and two month follow-up period design. The statistical population included women women with depression who referred to counseling centers and psychological services in the two cities of Tehran in the second half of 2021. 27 women with depression were selected through purposive sampling method and were randomly accommodated into experimental and control groups. The experimental group received mindfulness skills training sessions (eight sessions) during two months. The applied questionnaires included Depression Questionnaire (Beck, Epstein, Brown, Steer, 1996) and Social Health Questionnaire (Keyes, 2004). The data from the study were analyzed through mixed ANOVA and Bonferroni follow-up test. The results showed that mindfulness skills training has significant effect on the depression (F=24.57; Eta=0.47; P<0001) and social health (F=34.23; Eta=0.55; P<0001) in women with depression. According to the findings of the present study, mindfulness skills training can be used as an efficient method to decrease depression and improve social health in the women with depression through employing techniques such as mindful attitudes, mindful activities, addressing problem-making feelings and emotions and breathing exercises to manage anger.