Prevalence of neonatal jaundice in diabetic mothers referred to Kosar hospital in Qazvin in 2018-2019

Document Type : Research Paper

Authors

1 Assistant Professor, Clinical Research Development Unit, Qods Hospital, Qazvin University of Medical Sciences, Qazvin, Iran

2 Assistant Professor, Kausar Hospital, Qazvin University of Medical Sciences, Qazvin, Iran

3 Quds Hospital, Qazvin University of Medical Sciences, Qazvin, Iran

4 Assistant Professor, Baharlu Hospital, Department of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran

Abstract

Introduction: Hyperbilirubinemia is the most common cause of neonatal hospitalization in the first month after birth. Understanding the underlying causes of jaundice helps identify newborn at risk faster. The aim of this study was to determine the prevalence of jaundice in neonates with diabetic mothers on the 3rd to 5th day of after birth.
Materials and Methods: 120 pregnant mothers aged 18 to 40 years who had diabetes during pregnancy (familial or gestational diabetes) and were treated with insulin were included in this descriptive epidemiological study. All demographic information of the mother and infant is recorded in the checklists and after delivery, mothers are advised to visit the clinic on a routine checkup for jaundice (jaundice visible in the sclera) on the third to fifth day after birth. After a thorough neonatal examination, a total bilirubin test will be performed.
Results: Of 120 diabetic mothers, 54 (45%) had no jaundice, 24 (20%) had clinical jaundice, and 42 (35%) needed phototherapy. Statistical analysis showed that there were no significant differences between the three groups without jaundice, clinical jaundice and need for phototherapy in terms of gender, gestational age and Rh factor incompatibility but there was a significant difference between type of feeding, birth weight and incompatibility of ABO system. . Further statistical analysis showed that only birth weight factors and blood group incompatibility were associated with icterus.
Conclusion: Maternal diabetes and neonatal jaundice appear to be associated.

Keywords

Main Subjects

References

  1. National guidelines for treatment of jaundice in the newborn. 2011. D Bratlid, B Nakstad, TWR Hansen. Acta Paediatrica, Volume 100, Issue 4 p. 499-505
  2. Wong RJ, Bhutani VK, Abrams SA, Rand EB, Kim MS. Pathogenesis and etiology of unconjugated hyperbilirubinemia in the newborn. UpToDate Waltham, MA: UpToDate. 2015.
  3. Bergmann AU , Thorkelsson T. National guidelines for treatment of jaundice in the. Laeknabladid, 01 Mar 2020, 106(3):139-143Language:ice DOI:10.17992/lbl.2020.03.473 PMID: 32124737
  4. Neonatal Jaundice. Review. 2019. Pooja Abbey, Devasenathipathy Kandasamy & Priyanka Naranje.
  5. The Indian Journal of Pediatrics volume 86, pages 830–841 (2019)Cite this articleBuchanan TA, Xiang AH. Gestational diabetes mellitus. The Journal of clinical investigation. 2005;115(3):485-91.
  6. Bener A, Saleh NM, Al-Hamaq A. Prevalence of gestational diabetes and associated maternal and neonatal complications in a fast-developing community: global comparisons. International journal of women's health. 2011;3:367.
  7. Rafael Bottaro Gelaleti, Débora C. Damasceno, Marilza V. C. Rudge . 2016. Increased DNA Damage is Related to Maternal Blood Glucose Levels in the Offspring of Women With Diabetes and Mild Gestational Hyperglycemia, View all authors and affiliations Volume 23, Issue 3, https://doi.org/10.1177/1933719115602766
  8. Hod M, Merlob P, Friedman S, Schoenfeld A, Ovadia J. Gestational diabetes mellitus: a survey of perinatal complications in the 1980s. Diabetes. 1991;40(Supplement 2):74-8.
  9. Association AD. Gestational diabetes mellitus. Diabetes care. 2004;27(suppl 1):s88-s90.
  10. Porter ML, Dennis BL. Hyperbilirubinemia in the term newborn. American family physician. 2002;65(4).
  11. Bertini G, Dani C. Bilirubin Metabolism, Unconjugated Hyperbilirubinemia, and Physiologic Neonatal Jaundice. Neonatology: A Practical Approach to Neonatal Diseases. 2016:1-7.
  12. Gartner LM. Breastfeeding and jaundice. Journal of Perinatology. 2001;21(S1):S25.
  13. Afkhami M, Rashidi M. Gestational diabetes mellitus. Hormozgan Medical Journal. 2007;11(1):1-12.
  14. Ghosh S, Ghosh K. Maternal and neonatal outcomes in gestational diabetes mellitus. Journal of the Indian Medical Association. 2013;111(5):330-1, 6.
  15. Khatun N, Latif S, Uddin M. Risk factors for the development of gestational diabetes mellitus. Mymensingh medical journal: MMJ. 2009;18(1 Suppl):S20-3.
  16. Boskabadi H, Khakshour A, Khorashadi Zadeh F, Taherpur M, Esmaily H. Prenatal complications causing neonatal jaundice in Ghaem Hospital, Mashhad-Iran. Journal of North Khorasan University of Medical Sciences. 2011;3(2):7-12.
  17. Mimouni F, Miodovnik M, Siddiqi T, Butler J, Holroyde J, Tsang R. Neonatal polycythemia in infants of insulin-dependent diabetic mothers. Obstetrics and gynecology. 1986;68(3):370-2.
  18. Meur S, Mann NP. Infant outcomes following diabetic pregnancies. Paediatrics and child health. 2007;17(6):217-22.
  19. Mansouri A, Ghaderpanahi M, KAZEMI GM, Moradzadeh R, TOLIDE IH, Akbarpour S, et al. A CASE-CONTROL STUDY ON PRENATAL FACTORS OF NEWBORNS’MILD JAUNDICE. 2014.
  20. Javadi T, Mohsen Zadeh A. Examine the causes of jaundice in newborns admitted in Hospital of shahidmadani khoramabad in 2000. J Lorestan Univ Med Sci. 2005;4:73-8.
  21. Malinowska-Polubiec A, Czajkowski K, Sotowska A. Pregnancy and delivery course in patients with gestational diabetes mellitus. Ginekologia polska. 2003;74(10):1200
  22. Bertini G, Dani C, Tronchin M, Rubaltelli FF. Is breastfeeding really favoring early neonatal jaundice? Pediatrics. 2001;107(3):e41-e.
  23. Shah VA, Yeo CL. Identifying risk of neonatal hyperbilirubinaemia and early discharge for glucose-6-phosphate dehydrogenase deficient newborns in Singapore. ANNALS-ACADEMY OF MEDICINE SINGAPORE. 2007;36(12):1003
  24. ZARINKOUB F, BEYGI A. Epidemiology of hyperbilirubinemia in the first 24 hours after birth. 2007.
  25. Boskabadi H, Zakeri Hamidi M, Goudarzi M. Investigating the effect of maternal risk factors in incidence of neonatal jaundice. The Iranian Journal of Obstetrics, Gynecology and Infertility. 2012;15(34):1-6.
  26. Lavanya KR, Jaiswal S, Reddy P, Murki S. Predictors of significant jaundice in late preterm infants. Indian pediatrics. 2012;49(9):717-20.
  27. Melamed N, Klinger G, Tenenbaum-Gavish K, Herscovici T, Linder N, Hod M, et al. Short-term neonatal outcome in low-risk, spontaneous, singleton, late preterm deliveries. Obstetrics & Gynecology. 2009;114(2 Part 1):253-60.
  28. Saber A, Ferdowsi S, Askari F, Farsi L. Epidemiology of pathological jaundice and its association with demographic factors in infants born in the 22 Bahman Hospital in Gonabad, 2011. Razi Journal of Medical Sciences. 2013;20.
  29. Murki S, Kumar P, Majumdar S, Marwaha N, Narang A. Risk factors for kernicterus in term babies with non-hemolytic jaundice. Indian pediatrics. 2001;38(7):757-61.
  30. JAVIDI KJT, Mohsenzadeh A. Evaluation of the causes of jaundice in neonates admitted to Madani Hospital of Khorram Abad in 2002. 2006.
  31. Raeisi R, Heidari-Soureshjani S, Asadi-Samani M, Luther T. A systematic review of phytotherapies for newborn jaundice in Iran. Int J Pharm Sci Res. 2017;8(5):1953-8.
  32. Ghotbi N, Sheikh-Ahmadi K. Epidemiology of Pathologic Neonatal Jaundice in Sanandaj in 1998. 2001.
  33. Hyperviscosity in the neonate . M.D. Gary P. Gross, M.D. William E. Hathaway, M.D. H. Raymond McGaughey. The Journal of Pediatrics Volume 82, Issue 6, June 2010, Pages 1004-1012
  34. Gestational diabetes mellitus: risks and management during and after pregnancy. Thomas A. Buchanan, Anny H. Xiang & Kathleen A. Page Nature Reviews Endocrinology volume 8, pages 639–649 (2012)Cite this article
Medical Journal of Mashhad university of Medical Sciences
Volume 66, Issue 3
September and October 2023
Pages 426-439

Files

Share

How to cite

Statistics