The effect of eight weeks of high intensity interval training on the expression of 12.13.diHome, SREBP-1 genes and body composition in obese vistar rat

Document Type : Research Paper


1 PhD student of biochemistry and sports metabolism. Faculty of Sports Sciences, Ferdowsi University of Mashhad. Mashhad, Iran

2 Professor of biochemistry and sports metabolism. Faculty of Sports Sciences, Ferdowsi University of Mashhad. Mashhad, Iran

3 Associate Professor of Biochemistry and Sports Metabolism. Faculty of Sports Sciences, Ferdowsi University of Mashhad. Mashhad, Iran


Introduction: Adipose tissue is one of the tissues that affects the process of obesity. The aim of the present study was the effect of eight weeks of high intensity interval training on the expression of 12.13.diHome, SREBP-1 genes and body composition of non-obese rats.
working method; In the present study, 18 obese Wistar rats, aged eight weeks and weighing 343.88±42.20 grams, were randomly divided into two groups; high intensity interval training (10 heads) and control (8 heads). The rats of the experimental group performed high intensity interval training with an intensity of 85 to 90% of the maximum speed for eight weeks, five sessions a week, and Real Time-PCR method was used to measure the expression of 12.13.diHome and SREBP-1 genes. Became. Statistical methods of independent t-test and dependent t-test were used to check the statistical data at a significance level of P ≤ 0.05.
Results; The results of the present study showed that high intensity interval training led to a significant increase in the expression of the 12.13.diHome gene (P=0.01) and a decrease in the expression of the SREBP-1 gene. The same embryo caused a decrease in the weight (P=0.001) and body mass index (P=0.001) of the rats.
conclusion; According to the results of this research, it is suggested to use high intensity interval training that increase intramuscular lipolysis and decrease hepatic lipogenesis; To be used to reduce fat mass


Main Subjects

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