Medical Journal of Mashhad university of Medical Sciences

Medical Journal of Mashhad university of Medical Sciences

The Combined Effect of Fasting and Aerobic Exercise on Atherogenic Indices, Body Mass And ATF6 Gene Expression in Healthy liver Endoplasmic Reticulum of Wistar Rats

Document Type : Research Paper

Authors
Monireh Khalili 1
Habib Asgharpour 2
Asra Askari 3
Jahanbakhsh Asadi 4
1 Phd student of sports physiology, Department of Physical Education, Aliabad Katoul Branch, Islamic Azad University, Aliabad Katoul, Iran
2 Assistant Professor of Physical Education and Sports Sciences, Department of Physical Education, Aliabad Katoul Branch, Islamic Azad University, Aliabad Katoul, Iran.
3 Assistant Professor of Sports Physiology, Department of Physical Education, Gorgan Branch, Islamic Azad University, Gorgan, Iran
4 Full Professor of Metabolic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran
10.22038/mjms.2023.70813.4204
Abstract
Introduction
Endoplasmic reticulum plays an essential role in many cellular pathways. Exercise and fasting can lead to liver health by activating mechanisms such as reticulophagy. Therefore, the aim of the current research is to  investigate the effect of fasting and aerobic exercise on atherogenic indicators, body mass and ATF6 gene expression in the endoplasmic reticulum of healthy liver of Wistar rats.
Material and Method
In this experimental research, 30 Wistar rats (18 weeks old) with a weight range of 330.40 ± 25.34 grams were selected and divided into six groups: 1) control 2) starvation 3) 3 days of training 4) 5 days of training 5) 3 Day of training + starvation  6) 5 days of training + starvation were divided. The rats in the training group trained on the treadmill for one month, 3 and 5 sessions a week for one hour. Starvation was for 14 hours when the rats were awake, which was done continuously for one month. Data analysis was performed using one-way ANOVA and post hoc LSD statistical tests in SPSS version 23 software. A significance level of P≥0.05 was considered.
Results
Data analysis showed a significant decrease in BMI, LDL/HDL, CHOL/HDL, TAG/HDL and a significant increase in ATF6 gene expression (P≥0.05).
Conclusion
Aerobic training with starvation led to liver health by reducing atherogenic indicators. Also, increasing the expression of ATF6 gene in the liver through exercise and starvation can lead to the regulation of reticulophagia and liver health.
Keywords
starvation
aerobic exercise
atherogenic
activator of transcription factor 6
endoplasmic reticulum
Subjects
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Medical Journal of Mashhad university of Medical Sciences
Volume 66, Issue 4
September and October 2023