Comparison of two models of aerobic and resistance exercises on the expression of Piezo1 and Yoda1 genes in obese male Wistar rat

Document Type : Research Paper

Authors

1 PhD candidate, Sport Medicine Research Center, Najafabad Branch, Islamic Azad University, Najafabad, Iran

2 Assistant professor, Sport Medicine Research Center, Najafabad Branch, Islamic Azad University, Najafabad, Iran (Corresponding Author)

3 Assistant professor, Sport Medicine Research Center, Najafabad Branch, Islamic Azad University, Najafabad, Iran

Abstract

Introduction: Some diseases that are caused by continuous mechanical pressure and inflammation, which include cardiovascular diseases, osteoarthritis, insulin resistance, and disorders caused by obesity. The aim of the present study was to compare two models of endurance and resistance training on the expression of Piezo1 and Yoda1 genes in non-starved rats.
methodology; In the present study, 24 obese Wistar rats, eight weeks old and weighing 356.61±34.00 grams, were randomly divided into three groups; Endurance (8 heads), resistance (8 heads) and control (8 heads). The mice of the experimental groups performed five sessions of endurance training with an intensity of 70-80% of the maximum speed and resistance with an intensity of 50-120% of the body weight for eight weeks and to measure the expression of genes by Real Time-PCR method Used. The statistical method of one-way analysis of variance and Tukey's post hoc test was used to determine the difference between groups at a significant level of P ≤ 0.05.
Findings; The results of the present study showed that endurance and resistance exercises caused a significant increase in the expression of the Piezo1 gene (P=0.001) and a significant increase in Yoda1 (P=0.001) compared to the control group, but no difference was observed between the experimental groups (P=0.055), (P=0.387)
discussion and conclusion; Based on the results of this research, endurance and resistance exercises have a great impact on increasing the health of obese people by making changes in the expression levels of genes.

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medical journal of mashhad university of medical sciences
Volume 66, Issue 5
November and December 2023

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