Medical Journal of Mashhad university of Medical Sciences

Medical Journal of Mashhad university of Medical Sciences

The response of fibroblast-derived factor and endostatin to acute rehabilitation of physical activity along with electrical stimulation in infarcted rats

Document Type : Research Paper

Author
Mohammad Malekipooya
Assistant Professor, Department of Exercise Physiology, Arak Branch, Islamic Azad University, Arak, Iran.
10.22038/mjms.2024.75760.4448
Abstract
Introduction
Myocardial infraction is one of the main causes of death in today's society. Rehabilitation changes some markers in this disease. The aim of this research is to investigate the reaction of factor derived from fibroblasts and endostatin to the acute rehabilitation of physical activity along with electrical stimulation in infarcted rats.
Material and Method
In this controlled experimental study with a control group, 50 Wistar rats (8weeks old, 220±15g) were induced with isoproterenol (150mg/kg) to infarction. Then they were randomly divided into 5 groups of 10 healthy, infarct, rehabilitation, electrical stimulation and rehabilitation with electrical stimulation. The intervention groups underwent increasing rehabilitation (with a speed of 10 to 18m/min and duration of 50m) and electrical stimulation (a foot shock with an intensity of 0.5 M/A and duration of 20m) for one session. After exercise and anesthesia, venous blood samples were collected for FGF-2 and Ens serum levels and evaluated by ELISA method. ANOVA was used for data analysis at a significance level of P<0.05.
Results
Induction of rats with isoproterenol led to a significant increase in the serum levels of FGF-2 and Ens in all groups (P=0.0001). ANOVA showed that a session of rehabilitation led to a significant increase (P=0.040) of serum FGF-2 levels and a non-significant decrease (P=0.547) of Ens in all groups compared to infarction.
Conclusion
It seems that increasing acute rehabilitation by creating positive angiogenic changes in infarcted rats can play an important role in improving myocardial damage and replacing closed capillaries.
Key words
Keywords
Exercise Rehabilitation
Infarction
Fibroblast Growth Factor-2
Endostatin
Subjects
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Medical Journal of Mashhad university of Medical Sciences
Volume 67, Issue 4
May and June 2024
Pages 1249-1261