The effect of eight weeks of aerobic exercise with vitamin E supplementation on some neurotrophins in the hippocampal tissue of rats with Parkinson's disease

Document Type : Research Paper

Authors

1 PhD candidate, Sport Medicine Research Center, Najafabad Branch, Islamic Azad University, Najafabad, Iran

2 Assistant professor, Sport Medicine Research Center, Najafabad Branch, Islamic Azad University, Najafabad, Iran (Corresponding Author)

3 Assistant professor, Sport Medicine Research Center, Najafabad Branch, Islamic Azad University, Najafabad, Iran

Abstract

Introduction: Parkinson's disease (PD) is associated with disruption of neurotrophins. Previous studies have reported the favorable effect of exercise and some antioxidants. But their simultaneous effect is still not well known. Therefore, the aim of the present study was to investigate the effect of eight weeks of aerobic exercise with vitamin E supplementation on some neurotrophins in the hippocampal tissue of rats with Parkinson's disease.
Methods: In this experimental study, 40 Sprague-Dawley male rats (age 14-16 months and weight 250-270 grams) were given parkinsonism with 2 mg/kg reserpine (Rse) into groups (1) pd, ( 2) AT, (3) VE and (4) AT+VE were divided. In order to investigate the effects of Res on the variables, 8 rats were included in the healthy control group (HC). Aerobic training was done for eight weeks, five sessions a week and each session lasted 15-48 minutes at a speed of 10-24 meters per minute. VE was also taken orally at 30 mg/kg daily. To analyze the data, one-way analysis of variance and Tukey's post hoc test were used (P≥0.05).
Findings: BDNF and NGF gene expression values in VE, AT and VE+AT groups were significantly higher than PD group (P=0.001). Also, the increase of these two nortrophins in the AT+VE group was significantly higher than the VE and AT groups (P=0.001).
Conclusion: According to the results of this study, it seems that although aerobic exercise and vitamin E alone improve the expression of neurotrophins. However, these two interventions can strengthen each other's effects in the expression of neurotrophins in the conditions of Parkinson's disease modeling.

Keywords

References

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medical journal of mashhad university of medical sciences
Volume 67, Issue 1
March and April 2024
Pages 375-385

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