The effect of six weeks interval aerobic and aerobic continuous training with of jujubes extract administration on the plasma levels of nesfatin-1 in myocard infration male rats

Document Type : Research Paper

Authors

1 Professor of Exercise Physiology, Faculty of Sports Sciences, University of Birjand, Birjand, Iran

2 MSc in Exercise physiology, Faculty of Sports Sciences, University of Birjand, Birjand, Iran

3 Associate Professor of Immunology, Faculty of Agriculture, University of Birjand, Birjand, Iran

Abstract

Introduction: The present study was conducted with the aim of investigating the effect of continuous and periodic training along with the consumption of jujube extract on the plasma level of nesfatin-1 in rats.
Materials and Methods: The present study is experimental. 36 male ratswere purchased from the laboratory animal reproduction and breeding center of Birjand University of Medical Sciences with a weight range of 250-350 grams, and then suffered a heart attack through the induction of cardiac ischemia with subcutaneous injection of isoprenaline. Then they were divided into four groups of 6: control, intermittent aerobic exercise with jujube extract, intermittent aerobic exercise, continuous aerobic exercise with jujube extract, continuous aerobic exercise and jujube extract consumption group. Mice had free access to water and food. The jujube extract groups were gavage with a dose of 400 mg/kg and 1.5 cc of jujube extract per day. Results: The results showed that 6 weeks of intermittent and continuous aerobic training, alone and together with the consumption of jujube extract, caused a significant increase in plasma nesfatin-1 levels compared to the control group. Also, the consumption of jujube extract alone caused a significant increase compared to the control group. Between the effects of two types of sports training, intermittent training increased more than continuous training, but the difference was not significant.Conclusion: It seems that periodic and continuous exercise alone and with jujube extract as well as consumption of jujube extract alone increases nesfatin-1 in male rats suffering from heart attack.

Keywords

Main Subjects

References

  1. Saadi, P., Zainal Nejad, M., Mohdi Sobhani, F. (2021). Modeling and predicting the probability of coronary heart disease using data mining algorithms. Journal of Health and Biomedical Informatics , 8(2), 193-207.
  2. Hosseinpoor, M. (2022). Predicting Gestational Diabetes Using an Intelligent Algorithm Based on Artificial Neural Network. Journal of Modern Medical Information Sciences ,8(2),126-39.
  3. Yoon, H., Ahn, KO., Park, JH., Lee, SY. (2022). Effects of pre- hospital re-arrest on outcomes based on transfer to aheart attack centre in patients with out-of-hospital cardiac arrest. Resuscitation ,170,107-14.
  4. Khosrovinejad, Z., Naimi, S., Moghnibashi, M. M., & Khashai Vernamkheshadi, Kh. (2022) .The association of STAT4 gene polymorphism (rs3024839) with the probability of having a heart attack. Journal of the Faculty of Medicine of Mashhad University of Medical Sciences, 65(1), 12-20. doi: 10.22038/mjms.2022.62362.3654
  5. Su, Y., Zhang, J., Tang, Y., Bi, F., Liu, J-N. (2010). The novel function of nesfatin-1: anti-hyperglycemia. Biochemical and biophysical research communications,391(1),1039-42.
  6. Tawfik, M.S., et al. (2017). Effect of nesfatin-1 on ischaemia-reperfusion injury in isolated heart of albino rats. Zagazig University Medical Journal , 22(6).
  7. Angelone, T., Filice, E., Pasqua, T., Amodio, N., Galluccio, M., Montesanti, G., et al. (2013).Nesfatin-1 as a novel cardiac peptide: identification, functional characteri-zation, and protection against ischemia/reperfusion injury. Cell Mol Life ,70,495–509.
  8. Diem, G., Brownson, RC., Grabauskas, V., Shatchkute, A., Stachenko, S. (2016). Prevention and control of noncommunicable diseases through evidence-based public health: implementing the NCD 2020 action plan. Glob Health Promot , 23, 5-13
  9. Farzdipour Farkhian, A.R., Nabouti, E., Mir Ali, Kh., Anuri Tafti, Sh., and Rajabi Moghadam, H. A. (2019). smartphone-based application for teaching cardiac rehabilitation to outpatients: design and usability evaluation. Komesh, 22(4 ) 686-695
  10. Alavinia, S.E., Rashidalmir, A., Khajaei, R., and Ameena. (2021). Investigating the effect of a cardiac rehabilitation course based on combined exercise on VEGF gene expression in heart patients with a history of coronary bypass surgery. Animal Biology, 14(2), 13-22.
  11. Heydari, N., Ramezani, A.R., Minavand, Kh., and Karakhanlou, R. (2021). The effect of continuous and intermittent cardiac rehabilitation training on homocysteine, serum sodium-releasing atrial peptide and functional capacity in cardiac patients after coronary artery bypass grafting. Neishabur Faculty of Medical Sciences, 9(3) , 146-158.
  12. Chen, YW., Apostolakis, A., Gregory, Y., Lip H. (2014). Exercise-induced changes in inflammatory processes: Implications for thrombogenesis in cardiovascular disease. Ann Med , 439-455.
  13. Alabaf Yousefi, F., Pouzesh Jadidi, R., Bashiri, J., Vakili, J. (2021). Effects of HIIT and Curcumin Supplementation on Rat Cardiac Fibrosis Signaling Pathway Following Myocardial Infraction. RSMT ,19 (22),37-54.
  14. Nikoozadeh, A., Pouzesh-Jadidi, R., Nourazar, A., Asgharpour-Arshad, M., Bashiri, J. (2022). Effect of eight weeks of aerobic training and curcumin supplementation on PGC1-alpha gene expression and mitochondrial citrate synthase in Cardiomyocytes of male rats with myocardial infarction model. Feyz, 26 (4) ,398-406.
  15. Javaheri Tehrani, B., & Qari Arefi, R. (2019). The effect of eight weeks of intermittent aerobic training and consumption of jujube extract on the vascular endothelial growth factor of the heart tissue of male rats suffering from cardiac infarction. Movement and Behavioral Sciences, 3(1), 1-11.
  16. Hosseini, M., Bambaeichi, E., Sarir, H., kargarfard, M., Mogharnasi, M. (2018). The Effect of Six Weeks of Continuous Training with Ziziphus Jujube Extract Consumption on Lipocalin-2 and Adiponectin Levels in Plasma and Heart Tissue of Rats with Myocardial Infraction . Intern Med Today , 24 (3) ,193-202.
  17. Liang, S., Juan, J. (2011). Effect of jujube extract on oxidative injury in heart muscles of exhausted training rats. Afr J Microbiol Res,5(14),1896-9.
  18. Rabiei, M. A,, Mogharnasi, M., Sarir, H., & Khorashadizadeh, M.(2018). Investigating the effect of intermittent aerobic exercise and jujube extract on apoptotic factors in rats suffering from heart attack. Physiology and management research in sports ,11(1), 77-89.
  19. Karbalaeifar, S., Gaeini, A.A,, Kordi, MR., Nuri, R.,Ghorbani, P.(2016). The effect of 6-week high intensity interval training on the VEGF/COL-18 ratio and some echocardiographic indices in rats with myocardial infarction. J Kermanshah Univ Med Sci, 20(3),94-8.
  20. Serra, AJ., Santos, MH., Bocalini, DS., Antônio,EL., Levy, R.F., Santos, A.A, et al. (2010). Exercise training inhibits inflammatory cytokines and more than prevents myocardial dysfunction in rats withsustained β-adrenergic hyperactivity. J Physiol, 588(13), 2431-42.
  21. Xu, X., Zhao, W., Lao, S., Wilson, BS., Erikson, JM., Zhang, J.Q.(2010). Effects of exercise and L-arginine on ventricular remodeling and oxidative stress. Medicine and science in sports andexercise,42(2),346.
  22. Dashtban M, Sarir H, Omidi A.(2016). The effect of Prosopis farcta beans extract on blood biochemical parameters in streptozotocininduced diabetic male rats. Adv Biomed Res, 5, 116.
  23. Ghanbari Niaki, A., et al. (2012). The effect of 8 weeks of endurance training on hypothalamic Nesfatin-1 gene expression and its concentration in male rats. ISMJ ,15(3),171-182.
  24. Pahuja, M., Mehla, J, Reeta, K., Joshi, S., Gupta, YK. (2011). Hydroalcoholic extract of Zizyphus jujuba ameliorates seizures, oxidative stress, and cognitive impairment in experimental models of epilepsy in rats. Epilepsy & Behavior,21(4),356-63.
  25. Ebrahimi S, Sadeghi H, Pourmahmoudi A, Askariyan S, Askari S. (2011). Protective Effect of Zizphus Vulgaris Extract, on Liver Toxicity in Laboratory Rats. Armaghane Danesh, 2011; 16 (2) :172-180.
  26. Abdi, H., et al. (2015). The Combined Effect of Endurance Training and Various Doses of Atorvastatin on Cardiac Remodeling after Myocardial Infarction in Male Rats. Journal of Knowledge & Health,11(1), 32-40.
  27. Nunes, R., B., et al. (2015). Interval and continuous exercise enhances aerobic capacity and hemodynamic function in CHF rats. Brazilian journal of physical therapy,19(4), 257-263.
  28. Moghadasi, M., and A. M, Domieh,. . (2014). Effects of resistance versus endurance training on plasma lipocalin-2 in young men. Asian journal of sports medicine,5(2),108.
  29. Mohseni, Z., Abedi, B., Kazemzadeh, Y. (2024). The Effect of High-Intensity Interval Training and Thyme Supplementation on the Serum Levels of Irisin and Nesfatin-1 in Sedentary Young Girls: A Quasi-Experimental Study. JRUMS, 23 (3) ,137-149.
  30. Qamari, A., Ghahrmani, M., Mohammadi Javed, N. (2022). Comparison of the effect of two types of intense intermittent exercise and moderate continuous exercise with the consumption of peppermint essential oil on nesfatin-1 and body composition of overweight men. Applied Studies of Biological Sciences in Sports, 10(24), 32-41.
  31. Iqbali, E., Dadvand, S.Sh., & Taheri, M. (2016). The effect of resistance training with and without testosterone injection on plasma nesfatin-1 levels of adult male rats. Daneshvar Medicine, 25(3), 27-36.
  32. Moradi, M., Shabkhiz, F., Khalafi, M., and Talebi, V. (2017). The effect of acute aerobic exercise on hypothalamic nesfatin-1 gene expression in male rats made diabetic by streptozotocin method. Scientific Journal of Birjand University of Medical Sciences, 25(2), 104-113.
  33. Chaolu, H., Asakawa, A., Ushikai, M., Li, Y.X., Cheng, K.C., Li, J.B., et al. (2011). Effect of exercise and high-fat diet on plasma adiponectin and nesfatin levels in mice. Exp Ther Med, 2(2),369-373.
  34. Haqshanas, R., Ravasi, A.A., Kurdi, M.R., Hedayati, M., Shabkhiz, F., Shariatzadeh, M .(2013). The effect of twelve weeks of endurance training on weight, food intake and plasma nesfatin-1 of obese male rats. sports and movement biology,3(1),85-77.
  35. Bashiri, J., Gholami, F., Rahbaran, A., Tarmahi, V.(2012). The effect of a session of aerobic activity on serum nesfatin levels of elderly non-athletes. Tabriz University of Medical Science, 4,25-30.
  36. Tawfighi, A., Mehrabani, J., Khadevi, S. M. (2013). The effect of eight weeks of aerobic endurance training on the changes of nesfatin-1 and acyl ghrelin in young obese men.Mashhad University of Medical Sciences Faculty of Medicine Journal,57(3), 570-562.
  37. Ghanbari-Niaki, A., et al. (2010). Plasma nesfatin-1 and glucoregulatory hormone responses to two different anaerobic exercise sessions. European journal of applied physiology,110(4), 863-868.
  38. Ghanbari, Niaki., A., et al. (2012). The effect of 8 weeks of endurance training on hypothalamic Nesfatin-1 gene expression and its concentration in male rats. ISMJ ,15(3), 171-182.
  39. Afzalpour, M.s., Rezazadeh, A., and Abtahi, S.H. (2014). The effect of jujube consumption on total antioxidant capacity and lipid peroxidation in women after a session of intense resistance training. Scientific Research Journal of Sports and Bio-Motion Sciences,1 (11), 16-26.

 

  1. Ghanbari Niaki, A., Najafi, S., Hosseinzadeh, H., Mohammadi Jojadeh, F. (2013). the effect of 6 weeks of running on a treadmill with and without water extract of jujube fruit, on AgRP levels in the hypothalamus of female rats. the first national conference on physical education and sports sciences, Najafabad.
  2. Taati, M., Alirezaei, M., Meshkatalsadat, M.H., Rasoulian, B., Kheradmand, A., Neamati, S.h. (2011). Antioxidant effects of aqueous fruit extract of Ziziphus jujuba on ethanol-induced oxidative stress in the rat testes. Iranian Journal of Veterinary Research, (34), 39-45.
Medical Journal of Mashhad university of Medical Sciences
Volume 67, Issue 6
January and February 2025
Pages 1513-1524

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