Comparison of the effect of two types of aerobic exercise on the expression of GDNF gene and its receptor GFRα1 in Spinally Injured Rats

Document Type : Research Paper

Authors

1 Ph.D Candidate, Department of Physical Education and Sport Sciences, Bojnourd Branch, Islamic Azad University, Bojnourd, Iran.

2 Assistant Professor, Department of Sport Science, Islamic Azad University, Bojnurd Branch, Bojnurd, Iran

3 Assistant Professor, Department of medical physics and radiology, North Khorasan University of Medical Sciences, Bojnurd, Iran.

4 Assistant Professor, Department of Physical Education and Sport Sciences, Bojnourd Branch, Islamic Azad University, Bojnourd, Iran.

Abstract

Introduction
This study aimed to investigate 4-weeks of selected aerobic training on the expression of GDNF gene and its receptor GFRα1 in hippocampal rats with spinal cord injury (SCI).
Material and Method
In this experimental study, rats were randomly divided into 6 groups. Animals were subjected to spinal cord injury under general anesthesia and T11-T9 spine surgery, and after 2 weeks of recovery, aerobic exercises were performed on them. After training, hippocampal tissue was removed to examine the gene expression.
Results
The expression of GDNF in the SCI model was significantly decreased compared to the control group, and the expression of this gene was increased in the SCI group of the first exercise and in the SCI group of the second exercise compared to the SCI group; However, this increase did not show a significant difference between the two SCI groups. The expression of the GFRα1 receptor in the SCI model had a significant decrease compared to the control group. This expression was increased in the SCI group of the first exercise and in the SCI group of the second exercise compared to the SCI group; However, this increase did not show a significant difference between the two SCI groups.
Conclusion
The training protocols of this study increased the expression of the GDNF gene and its receptor GFRα1 in SCI rats, and it can be considered as a contributing factor to neural growth and neuronal survival in SCI models.

Keywords

Main Subjects

References

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Medical Journal of Mashhad university of Medical Sciences
Volume 67, Issue 5 - Serial Number 5
September and October 2024
Pages 1346-1357

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