The Effect of Four Weeks of Aerobic Exercise and Rice Bran Supplementation on the Changes of Lanosterol Synthase in Rats Fed with High-Fat Diet

Document Type : Research Paper

Authors

1 Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran

2 Department of Physical Education and Sport Sciences, East Tehran Branch, Islamic Azad University, Tehran, Iran

3 Department of Sports Physiology, pardis Branch, Islamic Azad University, Pardis, Iran

10.22038/mjms.2024.82883.4776

Abstract

Background and Aim: Obesity is one of the main factors in the development of cardiometabolic diseases, including dyslipidemia. Therefore, the purpose of this study was to investigate the effect of four weeks of aerobic training and rice bran supplementation on the changes of Lanosterol Synthase in rats fed with high-fat food.
Methods: In a preclinical trial, 30 8-week-old female rats were randomly divided into 5 groups (6 in each group), including control of feeding with normal food, control of feeding with high-fat food, aerobic exercise-feeding with high-fat food and Aerobic exercise-rice bran feeding with high-fat food was divided. One-way analysis of variance and Tukey's post hoc test were used for data analysis using SPSS-22 software.
Results: The results showed that the reduction of Lanosterol Synthase (P=0.003) was significant in the control group fed with normal food compared to the control group fed with high-fat food. the decrease in the expression of Lanosterol Synthase (P≥0.018) in the group fed with high-fat food-aerobic exercise-ethanol extract of rice bran was significant compared to the control group fed with high-fat food.
Conclusion: In general, it can be stated that the combination of four weeks of aerobic training and rice bran supplementation had positive effects on the changes of lanosterol synthase enzyme in rats fed with a high-fat diet.

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Medical Journal of Mashhad university of Medical Sciences
Volume 67, Issue 5 - Serial Number 5
September and October 2024

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