The Effect of Four Weeks of Aerobic Exercise and Rice Bran Supplementation on the Changes of Lanosterol Synthase in Rats Fed with High-Fat Diet

Document Type : Research Paper

Authors

1 Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran

2 Department of Physical Education and Sport Sciences, East Tehran Branch, Islamic Azad University, Tehran, Iran

3 Department of Sports Physiology, pardis Branch, Islamic Azad University, Pardis, Iran

Abstract

Background and Aim: Obesity is one of the main factors in the development of cardiometabolic diseases, including dyslipidemia. Therefore, the purpose of this study was to investigate the effect of four weeks of aerobic training and rice bran supplementation on the changes of Lanosterol Synthase in rats fed with high-fat food.
Methods: In a preclinical trial, 30 8-week-old female rats were randomly divided into 5 groups (6 in each group), including control of feeding with normal food, control of feeding with high-fat food, aerobic exercise-feeding with high-fat food and Aerobic exercise-rice bran feeding with high-fat food was divided. One-way analysis of variance and Tukey's post hoc test were used for data analysis using SPSS-22 software.
Results: The results showed that the reduction of Lanosterol Synthase (P=0.003) was significant in the control group fed with normal food compared to the control group fed with high-fat food. the decrease in the expression of Lanosterol Synthase (P≥0.018) in the group fed with high-fat food-aerobic exercise-ethanol extract of rice bran was significant compared to the control group fed with high-fat food.
Conclusion: In general, it can be stated that the combination of four weeks of aerobic training and rice bran supplementation had positive effects on the changes of lanosterol synthase enzyme in rats fed with a high-fat diet.

Keywords

Main Subjects

References

  1. ada H, Nohara A, Inazu A, Sakuma N, Mabuchi H, Kawashiri MA. Sitosterolemia, Hypercholesterolemia, and Coronary Artery Disease. J Atheroscler Thromb. 2018 Sep 1;25(9):783-789.
  2. ada H, Nomura A, Ogura M, Ikewaki K, Ishigaki Y, Inagaki K, Tsukamoto K, Dobashi K, Nakamura K, Hori M, Matsuki K, Yamashita S, Yokoyama S, Kawashiri MA, Harada-Shiba M. Diagnosis and Management of Sitosterolemia 2021. J Atheroscler Thromb. 2021 Aug 1;28(8):791-801.
  3. Aguilar-Ballester M, Herrero-Cervera A, Vinué Á, Martínez-Hervás S, González-Navarro H. Impact of Cholesterol Metabolism in Immune Cell Function and Atherosclerosis. Nutrients. 2020 Jul 7;12(7):2021.
  4. Alipour Talesh G, Trézéguet V, Merched A. Hepatocellular Carcinoma and Statins. Biochemistry. 2020 Sep 22;59(37):3393-3400.
  5. Alvarez-Jimenez L, Morales-Palomo F, Moreno-Cabañas A, Ortega JF, Mora-Rodriguez R. Statins effect on insulin resistance after a meal and exercise in hypercholesterolemic pre-diabetic individuals. Scand J Med Sci Sports. 2022 Sep;32(9):1346-1355.
  6. Alves, J. B., Rodrigues, M. H. P., Duarte, F. A., Furlong, E. B., & Christ-Ribeiro, A. (2023). Rice Bran and Its Potential To Complement the Nutritional Needs of Children and Elderly. Plant Foods for Human Nutrition, 78(1), 86-92.
  7. Aly DM, Fteah AM, Al Assaly NM, Elashry MA, Youssef YF, Hedaya MS. Correlation of serum biochemical characteristics and ABCG8 genetic variant (rs 11887534) with gall stone compositions and risk of gallstone disease in a group of Egyptian patients. Asian J Surg. 2023 Jun 19:S1015-9584(23)00823-0.
  8. André R, Pacheco R, Alves AC, Santos HM, Bourbon M, Serralheiro ML. The Hypocholesterolemic Potential of the Edible Algae Fucus vesiculosus: Proteomic and Quantitative PCR Analysis. Foods. 2023 Jul 20;12(14):2758.
  9. Balasubramanian R, Maideen NMP. HMG-CoA Reductase Inhibitors (Statins) and their Drug Interactions Involving CYP Enzymes, P-glycoprotein and OATP Transporters-An Overview. Curr Drug Metab. 2021;22(5):328-341.
  10. Banerjee A, Moreno A, Pata J, Falson P, Prasad R. ABCG: a new fold of ABC exporters and a whole new bag of riddles! Adv Protein Chem Struct Biol. 2021;123:163-191.
  11. Barkas F, Nomikos T, Liberopoulos E, Panagiotakos D. Diet and Cardiovascular Disease Risk Among Individuals with Familial Hypercholesterolemia: Systematic Review and Meta-Analysis. Nutrients. 2020 Aug 13;12(8):2436.
  12. Bastida JM, Girós ML, Benito R, Janusz K, Hernández-Rivas JM, González-Porras JR. Sitosterolemia: Diagnosis, Metabolic and Hematological Abnormalities, Cardiovascular Disease and Management. Curr Med Chem. 2019;26(37):6766-6775.
  13. Benn T, Kim B, Park YK, Wegner CJ, Harness E, Nam TG, Kim DO, Lee JS, Lee JY. Polyphenol-rich blackcurrant extract prevents inflammation in diet-induced obese mice. The Journal of nutritional biochemistry. 2014 Oct 1;25(10):1019-25.
  14. Berghoff SA, Spieth L, Saher G. Local cholesterol metabolism orchestrates remyelination. Trends Neurosci. 2022 Apr;45(4):272-283.
  15. Boonloh K, Kukongviriyapan V, Kongyingyoes B, Kukongviriyapan U, Thawornchinsombut S, Pannangpetch P. Rice Bran Protein Hydrolysates Improve Insulin Resistance and Decrease Pro-inflammatory Cytokine Gene Expression in Rats Fed a High Carbohydrate-High Fat Diet. Nutrients. 2015 Aug 3;7(8):6313-29.
  16. Brendolan A, Russo V. Targeting cholesterol homeostasis in hematopoietic malignancies. Blood. 2022 Jan 13;139(2):165-176.
  17. Butcher, Lee R, Thomas, Andrew, Backx, Karianne, et al. Low-intensity exercise exerts beneficial effects on plasma lipids via PPAR (gamma). Medicine & Science in Sports & Exercise, 2008; 40(7): 1263-70.
  18. Cao K, Zhang K, Ma M, Ma J, Tian J, Jin Y. Lactobacillus mediates the expression of NPC1L1, CYP7A1, and ABCG5 genes to regulate cholesterol. Food Sci Nutr. 2021 Sep 30;9(12):6882-6891.
  19. Cardoso D, Perucha E. Cholesterol metabolism: a new molecular switch to control inflammation. Clin Sci (Lond). 2021 Jun 11;135(11):1389-1408.
  20. Chatterjee A, Gerdes MW, Martinez SG. Identification of Risk Factors Associated with Obesity and Overweight-A Machine Learning Overview. Sensors (Basel). 2020 May 11;20(9):2734.
  21. Chen L, Zhao ZW, Zeng PH, Zhou YJ, Yin WJ. Molecular mechanisms for ABCA1-mediated cholesterol efflux. Cell Cycle. 2022 Jun;21(11):1121-1139.
  22. Chen QM. Nrf2 for cardiac protection: pharmacological options against oxidative stress. Trends Pharmacol Sci. 2021 Sep;42(9):729-744.
  23. Cheng HH, Huang HY, Chen YY, et al. Ameliorative effects of stabilized rice bran on type 2 diabetes patients. Ann Nutr Metab. 2010;56:45-51.
  24. Chung, H. R., Vakil, M., Munroe, M., Parikh, A., Meador, B. M., Wu, P. T., ... & Boppart, M. D. (2016). The impact of exercise on statin-associated skeletal muscle myopathy. PloS one, 11(12), e0168065.
  25. Cote I, Ngo Sock T, Levy E, Lavoie J M. An atherogenic diet decreases liver FXR gene expression and causes severe hepatic steatosis and hepatic cholesterol accumulation: effect of endurance training. Eur Nutr, 2012; 394(459).
Medical Journal of Mashhad university of Medical Sciences
Volume 67, Issue 6
January and February 2025
Pages 1547-1557

Files

Share

How to cite

Statistics