Document Type : Research Paper
Authors
1
General Doctor of Veterinary Medicine, Department of Veterinary Medicine , TaMS.C. , Islamic Azad University, Tabriz, Iran. (Corresponding author)
2
Specialized Doctorate in Veterinary Surgery, Department of Veterinary Medicine, TaMS.C., Islamic Azad University, Tabriz, Iran
3
Specialized Doctorate in Veterinary Pathobiology, Department of Veterinary Medicine, TaMS.C., Islamic Azad University, Tabriz, Iran.
10.22038/mjms.2025.26183
Abstract
Introduction: The present study aimed to investigate the effects of quercetin on wound healing in diabetic mice.
Methods: A total of 21 adult male mice were randomly assigned to three groups: healthy control, diabetic intervention, and diabetic control. Diabetes was induced in 14 mice through subcutaneous injection of streptozotocin at a dose of 50 mg/kg. A standardized wound of 3 cm was created on the mid-back of all wounded mice. Four weeks post-diabetes induction, the intervention group received quercetin treatment (50 mg/kg) for 21 days, while the control group did not receive any treatment. Wound area and healing percentage were measured on days 4, 8, 12, 16, and 21.
Results: One-way ANOVA results indicated a significant difference in healing percentages between the control and diabetic groups (F(2,18)=6.68, P=0.001). Duncan's post-hoc test revealed that the healing percentage in the healthy group was significantly higher than that in the diabetic groups, and the diabetic group receiving quercetin showed a significantly greater healing percentage compared to the diabetic control group.
Conclusion: These findings suggest that quercetin may enhance skin wound healing in diabetic mice, likely through the inhibition of inflammatory responses, promotion of angiogenesis, and increased cell proliferation.
Keywords