Medical Journal of Mashhad university of Medical Sciences

Medical Journal of Mashhad university of Medical Sciences

Investigation of changes in some neurotrophins in hippocampal tissue in an experimental autoimmune encephalomyelitis model following endurance training and royal jelly

Document Type : Research Paper

Authors
sara tavakolian 1
Maghsoud Peeri 2
Forouzan Fattahi 1
1 Department of Exercise Physiology - Central Tehran Branch - Islamic Azad University - Tehran - Iran
2 Department of Exercise Physiology- Central Tehran Branch- Islamic Azad University- Tehran-Iran
10.22038/mjms.2025.88004.5008
Abstract
Introduction: Neurotrophin disorders are a common mechanism in multiple sclerosis. Given the essential role of neurotrophins in cognitive function, the present study aimed to investigate the changes in some neurotrophins in hippocampal tissue in an experimental autoimmune encephalomyelitis (EAE) model following endurance exercise (ET) and royal jelly (RJ).
Methods: In this experimental study, 49 female Sprague-Dawley rats with EAE (with complete Freund's adjuvant) were divided into groups: (1) EAE, (2) Sham (Sh), (3) RJ mg/kg 50 (RJ50), (4) RJ100, (5) ET, (6) ET+RJ50, (7) ET+RJ100. To investigate the effect of EAE on the variables, 7 healthy rats were placed in the healthy control (HC) group. ET was performed for five weeks, four sessions per week at a speed of 11-15 m/min for 30 minutes, and RJ was injected intraperitoneally at doses of (50 and 100 mg/kg/day). One-way ANOVA and Tukey's post hoc test were used to analyze the findings (P≥0.05).
Results: The results of the present study showed that BDNF levels in the ET group were significantly higher than in the EAE group. The results of the present study showed that BDNF levels in the RJ50, RJ100, ET+RJ50, and ER+RJ100 groups were significantly higher than in the EAE group. In addition, TrKB gene expression levels in the RJ100 group were significantly higher than in the RJ50 group. Also, TrKB levels in the RJ50, RJ100, ET+RJ50, and ER+RJ100 groups were significantly higher than in the EAE group.
Keywords
Exercise
Royal Jelly
Neurotrophins
Hippocampus
Experimental Autoimmune Encephalomyelitis
Subjects
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Medical Journal of Mashhad university of Medical Sciences
Volume 68, Issue 4
May and June 2025
Pages 1068-1082