The effect of 12 weeks of combined training on serum homocysteine ​​and brain natriuretic peptide (NT-proBNP) in cardiovascular patients

Document Type : Research Paper

Authors

1 PhD student in Exercise Physiology, Department of Physical Education and Sports Sciences, South Tehran Branch, Islamic Azad University of Tehran. Iran

2 Associate of Exercise Physiology, Islamic Azad University, South Tehran Branch, Tehran, Iran.

3 Assistant Professor, Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Azad University, Zanjan Branch, Iran

4 Assistant Professor, Department of Sports Physiology, South Tehran Branch, Islamic

5 Assistant Professor, Department of Exercise Physiology, Islamic Azad University, Parand Branch, Iran

10.22038/mjms.2025.88756.5041

Abstract

Introduction: Inactivity is the basis for many diseases, including cardiovascular diseases. Today, lifestyle changes and consequently cardiovascular diseases are one of the common causes of death in the world. The aim of the present study is to determine the effect of combined exercise (aerobic and resistance) on homocysteine ​​and brain natriuretic peptide (N-terminal proBrain Natriuretic Pepted) levels in cardiovascular patients.
Methods: In this study, which was conducted with a pre-test and post-test design with a control group, 24 volunteer patients were randomly divided into 2 combined exercise groups (12 people) and control (12 people). The combined exercise group performed 3 sessions of aerobic and resistance exercises for 60 minutes per week for 3 months. Blood samples were taken 24 hours before the first exercise session and 48 hours after the last exercise session. In the inferential statistics section, paired t-test was used to compare intra-group differences and analysis of covariance was used to compare inter-group differences using SPSS version 26 software.
Results: Based on paired t-test, a significant decrease in homocysteine ​​and brain natriuretic peptide levels was observed in the combined exercise group after exercise (P<0.05). This decrease was not significant in the control group. Covariance analysis showed that the levels of these two variables were significantly reduced compared to the control group (P<0.05).
Conclusion: In general, the results showed that performing combined aerobic and resistance exercises can reduce the homocysteine ​​inflammatory index and also lead to a decrease in brain natriuretic peptide as a cardiac biomarker in cardiovascular patients.

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Medical Journal of Mashhad university of Medical Sciences
Volume 68, Issue 3
May and June 2025
Pages 701-689

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