Document Type : Research Paper
Authors
1
General Doctor of Veterinary Medicine, Department of Veterinary Medicine , TaMS.C. , Islamic Azad University, Tabriz, Iran.
2
Specialized Doctorate in Veterinary Surgery, Department of Veterinary Medicine, TaMS.C., Islamic Azad University, Tabriz, Iran
3
Specialized Doctorate in Veterinary Pathobiology, Department of Veterinary Medicine, TaMS.C., Islamic Azad University, Tabriz, Iran
10.22038/mjms.2025.88040.5010
Abstract
The present study aimed to investigate the effects of quercetin on wound healing in diabetic mice. A total of 21 adult male mice were randomly assigned to three groups: healthy control, diabetic intervention, and diabetic control. Diabetes was induced in 14 mice through subcutaneous injection of streptozotocin at a dose of 50 mg/kg. A standardized wound of 3 cm was created on the mid-back of all wounded mice. Four weeks post-diabetes induction, the intervention group received quercetin treatment (50 mg/kg) for 21 days, while the control group did not receive any treatment. Wound area and healing percentage were measured on days 4, 8, 12, 16, and 21. One-way ANOVA results indicated a significant difference in healing percentages between the control and diabetic groups (F(2,18)=6.68, P=0.001). Duncan's post-hoc test revealed that the healing percentage in the healthy group was significantly higher than that in the diabetic groups, and the diabetic group receiving quercetin showed a significantly greater healing percentage compared to the diabetic control group. These findings suggest that quercetin may enhance skin wound healing in diabetic mice, likely through the inhibition of inflammatory responses, promotion of angiogenesis, and increased cell proliferation.
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