The effect of eight weeks High Intensity Interval Training and Moderate Intensity Continuous Training on NF-Kb in prediabetes women

Document Type : Research Paper

Authors

1 PhD Student, Department of Exercise Physiology, ST.C., Islamic Azad University, Tehran, Iran

2 Associate Professor, Department of Exercise Physiology, ST.C., Islamic Azad University, Tehran, Iran

3 Assistant Professor, Department of Exercise Physiology, Parand Branch, Islamic Azad University, Tehran, Iran

10.22038/mjms.2025.85775.4910

Abstract

Introduction
Prediabetes is a condition in which blood sugar is higher than normal but has not yet turned into diabetes. If left untreated, prediabetes can turn into type 2 diabetes, which is one of the problems of the global health community and can be the basis for many diseases and physiological disorders of the body.
Material and Methods
In this study, 45 prediabetes women with blood sugar levels of 100 to 125 mg/dL who had referred to a diabetes clinic in districts 9 and 10 of Tehran were randomly divided into three groups of 15: high-intensity interval training (HIIT) group, moderate-intensity continuous training (MICT) group, and control group. The training groups performed the exercises for eight weeks, three sessions per week, according to the desired protocol. The dependent variable data were measured by sampling 10 cc of blood from the brachial vein 48 hours before the start of the course and 48 hours after 8 weeks, in a fasting state and in a sitting position. Paired t-tests, analysis of covariance, and Tukey's post hoc test were used to compare the data at a confidence level of 95% using SPSS27 software.
Results
The present study showed that HIIT and MICT training significantly reduced NF-Kb compared to the control group (P<0.05). It was also shown that MICT training had a greater effect on NF-Kb than HIIT (P<0.05).

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Medical Journal of Mashhad university of Medical Sciences
Volume 68, Issue 3
May and June 2025
Pages 657-665

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