Document Type : Research Paper
Authors
1
PhD student in exercise physiology, Department of Exercise Physiology, Islamshahr Branch, Islamic Azad University, Tehran, Iran
2
Assistant Professor of Exercise Physiology, Department of Physical Education and Sport Sciences, Parand Branch, Islamic Azad University, Tehran, Iran
3
Department of Sport Physiology, Faculty of Physical Education, Islamic Azad University, Islamshahr Branch, Tehran, Iran.
4
Assistant Professor of Exercise Physiology, Department of Exercise Physiology, Islamshahr Branch, Islamic Azad University, Tehran, Iran
5
Associate Professor, Department of Exercise Physiology, Faculty of Sport Sciences, South Tehran Branch, Islamic Azad University, Tehran, Iran
10.22038/mjms.2025.27320
Abstract
Introduction: Overweight and obesity are among the major public health challenges in today’s mechanized and sedentary world, threatening the health of large segments of society. The present study aimed to examine the effects of eight weeks of resistance training, continuous endurance training, and interval endurance training on dipeptidyl peptidase-4 (DPP4) and neuregulin-1 (NRG1) levels in overweight women.
Methods: The statistical population of this study included all overweight women residing in District 9 of Tehran. From this population, 40 women aged 25–35 years with a body mass index (BMI) between 25 and 30 kg/m² were voluntarily and conveniently recruited to participate in the study. Participants were randomly assigned to four groups: resistance training (n = 10), continuous endurance training (n = 10), interval endurance training (n = 10), and control (n = 10). The training groups followed their respective exercise protocols for eight weeks, three sessions per week. Data related to the dependent variables were collected through blood sampling conducted 48 hours before the onset of the intervention and 48 hours after completion of the 8-week training period. Fasting blood samples (10 mL) were obtained from the antecubital vein. Data were analyzed using analysis of covariance (ANCOVA) at a 95% confidence level with SPSS version 27.
Results: The results indicated that resistance training, continuous endurance training, and interval aerobic training had significant effects on DPP4 and NRG1 levels in overweight women (p < 0.05). Continuous endurance training elicited the greatest reduction in DPP4 levels compared with the other groups, followed by interval training and resistance training; however, the difference between resistance and interval training was not statistically significant. In contrast, resistance training produced the greatest increase in NRG1 levels compared with the other groups, followed by interval training and continuous endurance training, with no significant difference observed between the resistance and interval training groups.
Conclusion: Overall, the findings demonstrate that resistance training, continuous endurance training, and interval aerobic training all lead to improvements in the studied biomarkers. Nevertheless, for certain indices, these effects appear to be more strongly influenced by exercise intensity.
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