Opium Addiction as a Cause of Gastroduodenal Reflux in Dyspeptic Patients

Document Type : Research Paper


1 Associated professor Of Internal Group, Mashhad University of Medical Sciences, Mashhad, Iran

2 Associate Professor of Epidemiology, School of Public Health; Zahedan University of Medical SciencesZaheden, Iran

3 Asistant professor of Patalogy, Zahedan University of Medical SciencesZaheden, Iran

4 Medical doctor,Zahedan University of Medical SciencesZaheden, Iran


Drug abuse as a frequent high risk behavior accompanies many different gastrointestinal complications. In this study we tried to evaluate the prevalence of gastrointestinal reflux among opium addicts.
Materials and Methods
Using a historical cohort design, 62 cases with dyspepsia as the chief complaint entered the study: 30 cases with history of regular use of opium over the last year (exposed group) and 32 cases with no history of addiction at all (unexposed group). Upper GI tract endoscopy was accompanied by 3 biopsy specimens taken from body and antre of stomach was performed for all the cases.
2 cases in the exposed group and 3 cases in the unexposed group left the study with the diagnosis of malignancy. Mean age of the remaining cases in the exposed group was 48.1±13.2 and in the unexposed group, it was 37.8±13.9 years (p= 0.006). 16 cases (57.1%) in the exposed group and 5 cases (17.2%) in the unexposed group had endoscopic evidence of bile reflux into the stomach (p= 0.003). Pathologic evidence of bile gastritis including foveolar elongation was reported in 7 cases (25.0%) of the exposed group in comparison with 1 case (3.4%) of the unexposed group (p = 0.025). The frequency of "helicobacter pylori free gastritis" was 50% in the exposed group and 17.2% in the unexposed group (p = 0.012).
Duodenogastric reflux is not restricted to cases with a history of GI tract surgery and it seems that this problem is common among opium addicts


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