Evaluation of Carbamazepine and Oxcarbazepine on Tinnitus Otolaryngology – Head & Neck Surgery Research Center- Guilan University of Medical Sciences

Document Type : Research Paper

Authors

1 Associate professor of Otolaryngology Head & Neck Surgery, Guilan University of Medical Sciences,Rasht, Iran

2 Assistant professor of Neurology, Guilan University of Medical Sciences,Rasht, Iran

3 Assistant professor of Otolaryngology Head & Neck Surgery, Guilan University of Medical Sciences,Rasht, Iran

4 Assistant professor of Biostatistics, Guilan University of Medical Sciences,Rasht, Iran

5 Resident of Otolaryngology Head & Neck Surgery, Guilan University of Medical Sciences,Rasht, Iran

6 Medical Student, Guilan University of Medical Sciences,Rasht, Iran

Abstract

Introduction
Due to multiplicity of tinnitus etiologies and the lack of accurate knowledge about its exact mechanism, it is still a challenge to find an effective treatment. The objective of this study was an evaluation of carbamazepine and oxcarbazepine effect on tinnitus in patients’ reffered to Amiralmomenin Hospital Rasht-Iran.
Materials and Methods
In a randomized double-blind clinical trial, a total of 57 patients (23 to 71 years old) with chronic nonpulsatile tinnitus were treated in three separate groups with carbamazepine (300-600mg), oxcarbazepine (450-900 mg) and placebo for 12 weeks. In the early stages of the study, physical examination and nessecary laboratory tests, audiometry tests, complementation of Visual Analogue Scale (VAS) and Tinnitus Severity Index (TSI) were performed. At the end of 8th and 12thweeks, VAS and TSI questionnaire were completed again.
Results
Among 51 patients (28 male, 23 female) who completed the trial course, according to VAS, carbamazepine, oxcarbazepine and placebo decreased severity of tinnitus in 56.6%, 46.2% and 38.5% of cases respectively. Decrement in tinnitus severity on the basis of TSI in the three mentioned groups were 61.1%, 58.8% and 50% respectively. Carbamazepine and oxcarbazepine were not more effective than placebo in subsiding tinnitus on the basis of VAS and TSI.
Conclusion
Carbamazepine and its analouge, oxcarbazepine are effective in decreasing tinnitus severity, but they are not significantly more effective than placebo.

Keywords

References

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medical journal of mashhad university of medical sciences
Volume 55, Issue 1 - Serial Number 1
May and June 2012
Pages 46-51

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