Evaluation of Gamma-Interferon in diagnosis of Tuberculosis Pleurisy Lung diseases & TB research center

Document Type : Research Paper


1 Assistant professor of pulmonology, Mashhad University of Medical Sciences, Mashhad, Iran

2 Assistant professor of Immunology, Mashhad University of Medical Sciences, Mashhad, Iran

3 Assistant professor of pulmonology, Zahedan University of medical sciences, Zahedan, Iran

4 Professor of pulmonology, Mashhad University of Medical Sciences, Mashhad, Iran

5 Associated professor of Pulmonology, Mashhad University of Medical Sciences, Mashhad,Iran

6 Associated professor of biostatistics, Mashhad University of Medical Sciences, Mashhad, Iran

7 M.D, Immunology research center, Mashhad University of Medical Sciences, Mashhad, Iran

8 M.D, Lung diseases & TB research center, Mashhad University of Medical Sciences (MUMS), Mashhad, Iran


Differential diagnosis between Tuberculosis pleurisy and Non Tuberculoses pleural effusion can be sometimes difficult and needs invasive diagnostic methods. In recent years, several biological markers have been found to be diagnostic markers of Tuberculosis pleurisy. The aim of this study was assessment of the value of Gamma-Interferon in the diagnosis of TB pleurisy.
Materials and Methods
We studied 70 patients with pleural effusion who had been admitted to Ghaem hospital, Mashhad University of Medical Sciences, Mashhad, Iran. Interferon gama level was measured by "ELISA" method. The diagnosis of tuberculosis was based on microbiologic study of pleural fluid plus pleural biopsy.
Altogether Twenty patients had tuberculosis pleurisy (44.44%), 21 patients had malignant pleural effusion (46.67%) and 4 patients had pleural effusion with various non TB non malignant etiologies (8.9%). The sensitivity, specificity of Gamma-Interferon in TB pleurisy were 60% and 96% respectively.
INFγ is a valuable indicative marker for diagnosis of tuberculosis pleurisies’ but we should consider situations with high level of INFγ without any evidence of TB and also Tuberculsis Pleurisy patients with INFγ level lower than diagnostic threshold.


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