A Comparative Study of Serum Zinc Level between Asthmatic and Control Group

Document Type : Research Paper


1 Assistant professor, Immunologist and Allergist, Ghaem Hospital, Mashhad University of Medical Sciences ,Mashhad, Iran

2 Associated Professor of Pediatrics, Dr. Sheikh Hospital, Mashhad University of medical sciences ,Mashhad, Iran

3 Anatomy Clinical Pathology

4 Resisdent of Pediatrics


During the past decade Asthma have been increased worldwide. Free radicals have been proposed to be responsible or the pathogenesis of many diseases because of their harmful effects on the cells and tissues.There are some defense mechanisms in the organism to avoid the harmful effects of free radicals. The most important antioxidants are glutathione peroxidase and superoxide dismutase. Glutathione peroxidase has selenium and superoxide dismutase system has zinc in their structures which diminish the harmful effects of oxygen free radicals. This research was done to analyze the relation between serum zinc concentrations as antioxidant in children asthma.
Materials and Methods
This was a case study. We made comparison between 80 asthmatic patients. Who attended the pediatric allergy outpatients clinics and 80 control group children who attended the pediatric outpatient clinic for the complaints of non specific non-chronic disorders (acute upper respiratory system infection, urinary tract infection e.t.c) without any of history of atopy. None of the patients in the study used systemic or inhaled steroids and nonsterioidal anti inflammatory for the last 2 weeks. The serum zinc was measured with manual calorimetric method and then the results were compared.
In this study the overage age in case group was (6.07± 2.07 yrs) and in control group was (5.25±3.44 yrs). Therefore, no significant difference was detected. In view of gender both groups were totally identical. Mean serum zinc in patients was 93.93±25.58 mg/dl and in controls was 97.18±23.59 mg/dl; With no statistical difference (P>0.05).
It was not approved that serum zinc concentrations were lower in the asthmatic patients than normal individuals.


1- Ober C. Perspectives on the past decade of asthma genetics. J Allergy Clin Immunol 2005; 116:274-278.
2- Kelly FJ, Mudway I, Blomberg A, Frew A, Sandstrom T.Altered lung antioxidant status in patients with asthma.
Lancet 1999; 354:482.
3- Jarjoun NN, Calhoun WJ. Enhanced production of oxygen radicals in asthma. J Lab Clin Med 1994; 123:131-136.
4- Dworsk R. Oxidant stress in asthma. Thorax 2000; 55:551-553.
5- Halliwell B.Free radicals, antioxidant and human disease:Curiosity,cause or consequence? Lancet 1994; 344:721-
6- Shanmugasundaram KR, Kumar SS, Rajajee S. Excessive free radical generation in the blood of children suffering
from asthma. Clin Chim Acta 2001; 305:07-114.
7- Pucheu S. Coudray C, Tresallet N, Favier A, de-leiris J. Effect of dietary antioxidant trace elements supply on
cardiac tolerance to ischemia-reperfusion in the rat. J Mol Cell Cardiol 1995; 27:2303-2314.
8- Raeve HR, Thunnisen B, Kaneko FT, Cuo FH, Lewis M. Decreased cu,zn-SOD activity in asmathic air way
epithelium: Correction by Inhaled corticosteroid invivo. Am J physiol 1997; 272:148-154.
9- Comhair SA, Ricc KS, Arroliga M, Lara AR, Dweik RA, Song W.Correlation of systemic superoxide dismutase
deficiency to Air flow obstruction in Asthma. Am J Respir Crit Med 2005; 172:300-313.
10- Schauer U, Leinhass C, Joger R, Rigeger CHI. Enhanced superoxide generation by eosinophils from asthmatic
children. Int Arch Allergy Appl Immunol 1991; 96:317-321.
11- Di Toro R, Galdo Captorti, Gialanella G. Zinc and copper status of allergic children. Acta Paediatr Scand 1987;
12- Sprietsma JE. Modern diets and disease No-Zinc balance. Med Hypotheses 1999; 53:6-16.
13- Spristma JE. Zinc controlled TH1/TH2 switch significantly determines development of disease. Med Hypotheses
1997; 49:1-14.
14- El-Kholy MS, Gas Allah MA, El-shimi S, el-Baz F, el- Tayeb H, Abod-Hamid MS. Zinc and copper status in
children with bronchical asthma and atopic dermatitis. J Egypt public Health Assoc 1990; 65:657-668.
15- Vural H, Uzun K, Us E, Kocyigit A, Cigil A, Kyol O. Concentrations of copper, zinc and various elements in serum
of patients with bronchial asthma. J Trace Elem Med Biol 2000 ; 2:88-91.
16- Uzuner N, Karaman D, Coker C, Targut S, Uzuner H.Serum trace elements level in bronchial asthma. turkis
respiratory 2000; 2:10-15.
17- Ermis B, Armutcu F, Gurel A, Ermis B.Trace elements status in children with bronchial asthma. Eur J Gen Med
2004; 1:4-8.
18- Hasselmark L, Malmgren R, zetterstrom O, unge G.Selenium supplementation in intrinsic. Allergy 1993; 48:30-33.
19- Lang C, mugia C, leong M, Tan LW, Perozzi G, knight D, et al. Anti- inflammatory effects of zinc and alterations
in zinc transporter mRNA in mouse models of allergic inflamitaon AM J Physiol lung cell Mol physiol 2007; 292:577-
20- Luis DA, Lzaola O, Aller R, Armentia A, cuelar L. Antixidant and fat in patients with polinic asthma. Med Clin
(Barc) 2003; 121653-654.
21- Kocyigit A, Armutch F, Gurel A, Ermis B. Alterations in plasma assential trace elements selenium, mangment
copper, and iron concentration and the possible role of these elen oxidative status in patients with childhood asthma.
Boil Trace Elem Res 2004; 97:31-41.
22- Picado C, Deulofea R, Lieonart R, Agusti M, Mullol J, Quinto L. Dietary micronutrient / antioxidants and their
relation ship with bronichial asthma severity. Allergy 2001; 56:43-49.