A Study of Relation between Plasma Level of Insulin-like Growth Factor-1 (IGF-1) and Severity of Coronary Artery Disease

Document Type : Research Paper

Authors

1 Assistant Professorof Cardiology, Shafa Hospital, Kerman University of Medical Sciences, Kerman, Iran

2 Associate Professor of Cardiology, Shafa Hospital, Kerman University of Medical Sciences, Kerman, Iran

3 Resident of Internal Medicine of Cardiology, Shafa Hospital, Kerman University of Medical Sciences, Kerman, Iran

4 General Practitioner of Afzalipour Hospital, KermanUniversity of Medical Sciences, Kerman, Iran

Abstract

Introduction
Atherosclerosis and its related diseases are major causes of mortality in many countries. Our knowledge of its background is of much importance. In recent years, researches have been preformed on relation between atherosclerosis and IGF-I plasma levels and different results obtained. We decided to do this research, as few studies have been done in this field in our country.
Materials and Methods
Altogether One hundred and seven patients who were candidates for the coronary angiography were chosen for study. Blood samples were taken for measuring IGF-I, FBS, triglyceride, total cholesterol, LDL and HDL in plasma. Blood pressures of patients were recorded, and their BMIs accounted. It was also written in questionnaire if they had history of cigarette smoking.
Results
IGF-I plasma levels increased in relation to intensity of coronary artery stenosis; correlation coefficient between stenoses and IGF-I plasma levels was as follows: R= 0.204 p= 0.04. This suggested significant and meaningful relation between these variables. IGF-I plasma levels also showed mild increase in relation to number of diseased coronary arteries. By using the analysis of spierman correlation coefficient, Rho= 0.189 and p= 0.058 were accounted.
Conclusion
We concluded that IGF-I plasma levels were in direct and meaningful relation to stenosis values of coronary arteries, and in mild relation to number of diseased coronary arteries. These findings can explain the role of IGF-1 in process of atherosclerosis.
 

Keywords

References

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medical journal of mashhad university of medical sciences
Volume 53, Issue 1 - Serial Number 1
March and April 2009
Pages 11-15

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