Evaluation Effect of Topical Zinc Oxide Ointment on Healing of the Open Wounds Due to Surgery of Pilonidal Sinus

Document Type : Research Paper


1 Associated Professor of General surgery, Semnan University of medical sciences, Semnan, Iran

2 General Physician, Department Surgery of Amiralmomenin hospital, Semnan, Iran

3 Associated Professor of Biostatistics, Semnan University of medical sciences, Semnan, Iran


Pilonidal sinuses typically occur in the midline of the sacrococcygeal skin of young men that is treatment is surgical management. Since its wound healing typically requires long time and information about benefits of zinc compounds in wound healing, we asked to evaluate of the effect of topical zinc oxide ointment on healing of the acute open wounds due to surgery of pilonidal sinus.
Materials and Methods
In double blind, randomized, placebo control study sixteen men were not been diabetic, renal failure or cirrhotic and not used corticosteroids, after surgery with complete simple excision approach, evaluated in two groups that have been dressed daily with topical zinc oxide ointment (case group) and placebo (control group). Every 15 days average of percentage of wound healing has been compared in two groups by measuring of volume of wounds.
Mean of age in patients was 24.5±4, has no significant difference in groups (p= 0.634). Means of percentage of volume changes in first and second 15 days have no significant difference in groups (p= 0.334), (p= 0.175). But means of percentage of volume changes in third 15 days and in total 45 days duration of treatment have significant difference (p= 0.006), (p= 0.026).
In attention to this study and other searches, dressing with zinc oxide ointment is benefit in increase of healing rate of chronic and acute wounds. The effect of drug is significant in third 15 days that is properly because of principle effect of zinc in epithelialization phase.


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